Protein: TAL1
T-cell acute lymphocytic leukemia protein 1 (TAL-1) (Class A basic helix-loop-helix protein 17) (bHLHa17) (Stem cell protein) (T-cell leukemia/lymphoma protein 5)

Gene: TAL1
Organism: Homo sapiens
Interactions: 97
UniProt ID: P17542

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000976 - transcription cis-regulatory region binding
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

587410

TFE2
Transcription factor E2-alpha

9

20

Small-scale

0.976

High

605218

HTF4
Transcription factor 12

7

20

Small-scale

0.963

High

586995

ITF2
Transcription factor 4

6

20

Small-scale

0.944

High

605169

RBTN2
Rhombotin-2

5

17

Small-scale

0.935

High

605170

RBTN1
Rhombotin-1

2

17

Small-scale

0.807

High

605178

ID4
DNA-binding protein inhibitor ID-4

2

20

High-throughput

0.798

High

605209

LDB1
LIM domain-binding protein 1

4

4

Small-scale

0.699

High

604783

HXB9
Homeobox protein Hox-B9

1

20

High-throughput

0.698

High

558952

LYL1
Protein lyl-1

1

19

Small-scale

0.691

High

270232

MTG16
Protein CBFA2T3

3

11

Small-scale

0.678

High

605196

EP300
Histone acetyltransferase p300

3

16

Small-scale

0.676

High

605189

SSBP2
Single-stranded DNA-binding protein 2

3

3

Small-scale

0.667

High

605221

SSBP3
Single-stranded DNA-binding protein 3

3

4

Small-scale

0.667

High

605203

TAL2
T-cell acute lymphocytic leukemia protein 2

1

18

High-throughput

0.646

High

605217

SIN3A
Paired amphipathic helix protein Sin3a

2

2

Small-scale

0.629

High

605199

HDAC1
Histone deacetylase 1

2

7

Small-scale

0.621

High

605211

HDAC2
Histone deacetylase 2

2

7

Small-scale

0.621

High

605226

ZHX1
Zinc fingers and homeoboxes protein 1

1

5

High-throughput

0.621

High

605191

RUNX1
Runt-related transcription factor 1

2

4

Small-scale

0.618

High

605215

SIR1
NAD-dependent protein deacetylase sirtuin-1

2

5

High-throughput

0.618

High

605163

TAL1
T-cell acute lymphocytic leukemia protein 1

1

18

Small-scale

0.618

High

605197

CHD3
Chromodomain-helicase-DNA-binding protein 3

2

8

Small-scale

0.614

High

442578

RB
Retinoblastoma-associated protein

2

1

Small-scale

0.611

High

246424

KDM1A
Lysine-specific histone demethylase 1A

1

3

Small-scale

0.597

High

590378

GATA1
Erythroid transcription factor

2

9

Small-scale

0.586

High

605192

SATB1
DNA-binding protein SATB1

1

0

Small-scale

0.586

High

605227

CHIP
E3 ubiquitin-protein ligase CHIP

2

2

Small-scale

0.584

High

605213

KAT2B
Histone acetyltransferase KAT2B

1

7

Small-scale

0.578

High

464792

SP1
Transcription factor Sp1

1

5

Small-scale

0.573

High

605168

GATA3
Trans-acting T-cell-specific transcription factor GATA-3

2

9

Small-scale

0.571

High

605225

RCOR1
REST corepressor 1

1

4

Small-scale

0.554

High

605228

TRI33
E3 ubiquitin-protein ligase TRIM33

1

7

Small-scale

0.554

High

605183

CDK9
Cyclin-dependent kinase 9

1

2

Small-scale

0.536

High

605202

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

9

Small-scale

0.536

High

605204

RBBP7
Histone-binding protein RBBP7

1

3

Small-scale

0.536

High

605223

SIR5
NAD-dependent protein deacylase sirtuin-5, mitochondrial

1

5

High-throughput

0.536

High

605231

SP16H
FACT complex subunit SPT16

1

1

Small-scale

0.536

High

605165

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

13

Small-scale

0.515

High

605207

NPNT
Nephronectin

1

1

High-throughput

0.515

High

605167

GATA2
Endothelial transcription factor GATA-2

1

9

Small-scale

0.508

High

605229

DRG1
Developmentally-regulated GTP-binding protein 1

1

2

Small-scale

0.508

High

280491

PR40A
Pre-mRNA-processing factor 40 homolog A

1

2

High-throughput

0.500

High

577400

ETS1
Protein C-ets-1

1

15

Small-scale

0.500

High

605172

STIP1
Stress-induced-phosphoprotein 1

1

2

High-throughput

0.500

High

605175

SYIC
Isoleucine--tRNA ligase, cytoplasmic

1

1

High-throughput

0.500

High

605182

RBM25
RNA-binding protein 25

1

3

High-throughput

0.500

High

605206

UBR4
E3 ubiquitin-protein ligase UBR4

1

3

High-throughput

0.500

High

605216

HEXI2
Protein HEXIM2

1

3

High-throughput

0.500

High

605220

MBB1A
Myb-binding protein 1A

1

2

High-throughput

0.500

High

605222

BC11B
B-cell lymphoma/leukemia 11B

1

4

Small-scale

0.500

High

605171

EF1D
Elongation factor 1-delta

1

0

High-throughput

0.479

High

605174

RL13A
Large ribosomal subunit protein uL13

1

0

High-throughput

0.479

High

605179

PSMD8
26S proteasome non-ATPase regulatory subunit 8

1

0

High-throughput

0.479

High

605184

SYRC
Arginine--tRNA ligase, cytoplasmic

1

0

High-throughput

0.479

High

605185

ECHB
Trifunctional enzyme subunit beta, mitochondrial

1

0

High-throughput

0.479

High

605187

PSA6
Proteasome subunit alpha type-6

1

0

High-throughput

0.479

High

605188

RS13
Small ribosomal subunit protein uS15

1

0

High-throughput

0.479

High

605219

PSMD1
26S proteasome non-ATPase regulatory subunit 1

1

0

High-throughput

0.479

High

187000

PPM1G
Protein phosphatase 1G

1

1

High-throughput

0.479

High

216162

MTG8R
Protein CBFA2T2

1

11

Small-scale

0.479

High

216373

SUV91
Histone-lysine N-methyltransferase SUV39H1

1

5

Small-scale

0.479

High

342100

BRD1
Bromodomain-containing protein 1

1

7

Small-scale

0.479

High

486933

PARP1
Poly [ADP-ribose] polymerase 1

1

1

Small-scale

0.479

High

519327

MYB
Transcriptional activator Myb

1

1

Small-scale

0.479

High

541813

TOP1
DNA topoisomerase 1

1

1

Small-scale

0.479

High

557839

XRCC6
X-ray repair cross-complementing protein 6

1

2

Small-scale

0.479

High

571865

TRI27
Zinc finger protein RFP

1

2

Small-scale

0.479

High

586217

ZEP1
Zinc finger protein 40

1

7

High-throughput

0.479

High

605164

RCC1
Regulator of chromosome condensation

1

4

Small-scale

0.479

High

605176

CRK
Adapter molecule crk

1

5

High-throughput

0.479

High

605181

CTCF
Transcriptional repressor CTCF

1

5

High-throughput

0.479

High

605194

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

1

Small-scale

0.479

High

605198

SKP2
S-phase kinase-associated protein 2

1

3

Small-scale

0.479

High

605200

CUL3
Cullin-3

1

4

High-throughput

0.479

High

605208

I2BP2
Interferon regulatory factor 2-binding protein 2

1

2

Small-scale

0.479

High

605212

CBP
CREB-binding protein

1

15

High-throughput

0.479

High

605230

TRRAP
Transformation/transcription domain-associated protein

1

3

Small-scale

0.479

High

605210

CNDG2
Condensin-2 complex subunit G2

1

0

Small-scale

0.460

High

164523

TNPO2
Transportin-2

1

0

High-throughput

0.458

High

442996

PTMA
Prothymosin alpha [Cleaved into: Prothymosin alpha, N-terminally processed; Thymosin alpha-1]

1

0

High-throughput

0.458

High

605166

PTMS
Parathymosin

1

0

High-throughput

0.458

High

605214

ESPB1
Epididymal sperm-binding protein 1

1

1

Small-scale

0.457

High

522371

ODP2
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial

1

2

High-throughput

0.457

High

605186

SYMC
Methionine--tRNA ligase, cytoplasmic

1

1

High-throughput

0.457

High

605190

SPTB2
Spectrin beta chain, non-erythrocytic 1

1

9

High-throughput

0.457

High

605195

LG3BP
Galectin-3-binding protein

1

2

High-throughput

0.457

High

605201

DYHC1
Cytoplasmic dynein 1 heavy chain 1

1

2

High-throughput

0.457

High

605224

SYLC
Leucine--tRNA ligase, cytoplasmic

1

1

High-throughput

0.457

High

605193

KPCT
Protein kinase C theta type

1

2

Small-scale

0.439

High

539287

ODB2
Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial

1

2

High-throughput

0.437

High

605205

KLH22
Kelch-like protein 22

1

0

High-throughput

0.426

High

300911

RL1D1
Ribosomal L1 domain-containing protein 1

1

0

High-throughput

0.261

Low

576705

SYDC
Aspartate--tRNA ligase, cytoplasmic

1

0

High-throughput

0.261

Low

605173

ATPG
ATP synthase F(1) complex subunit gamma, mitochondrial

1

0

High-throughput

0.261

Low

605177

SYQ
Glutamine--tRNA ligase

1

0

High-throughput

0.261

Low

605180

RL34
Large ribosomal subunit protein eL34

1

0

High-throughput

0.261

Low


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Last updated: 11Aug2025