HitPredict

Interactor 1: LYL1 (P12980)
Protein lyl-1 (Class A basic helix-loop-helix protein 18) (bHLHa18) (Lymphoblastic leukemia-derived sequence 1)
Gene: LYL1

Interactor 2: RBTN2 (P25791)
Rhombotin-2 (Cysteine-rich protein TTG-2) (LIM domain only protein 2) (LMO-2) (T-cell translocation protein 2)
Gene: LMO2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.621

Property	Details
Experiments	7957052
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	HLH~LIM
Common GO terms	GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 280 Hs			1 158
+	Hs
		558957 LYL1_HUMAN (1-280): 9.09e-54: 177: 100.00		RBTN1_HUMAN (20-150): 3.92e-39: 131: 55.73
+	Hs
		1229352 FIGLA_HUMAN (96-280): 1.37e-29: 113: 26.04		LHX8_HUMAN (24-148): 1.11e-47: 159: 33.60
+	Hs
		605169 TAL1_HUMAN (51-267): 1.71e-34: 128: 40.83		RBTN2_HUMAN (1-158): 5.59e-42: 138: 100.00
+	Mm
		644244 TAL1_MOUSE (55-219): 1.8e-32: 123: 45.78		RBTN2_MOUSE (1-158): 4.12e-42: 139: 99.37
+	Hs
		605170 TAL1_HUMAN (51-267): 1.71e-34: 128: 40.83		RBTN1_HUMAN (20-150): 3.92e-39: 131: 55.73
+	Mm
		644382 TAL1_MOUSE (55-219): 1.8e-32: 123: 45.78		LMO3_MOUSE (30-156): 6.25e-39: 130: 58.27
+	Hs
		1246450 FIGLA_HUMAN (96-280): 1.37e-29: 113: 26.04		LHX6_HUMAN (7-153): 2.26e-38: 135: 27.70
+	Hs
		681821 TAL2_HUMAN (149-215): 7.29e-27: 102: 67.16		RBTN2_HUMAN (1-158): 5.59e-42: 138: 100.00
+	Hs
		223960 TCF21_HUMAN (130-209): 1.65e-27: 106: 39.51		LMO4_HUMAN (11-147): 1.13e-38: 130: 42.34
+	Hs
		581779 MYOG_HUMAN (95-279): 4.48e-27: 106: 18.42		LMO3_HUMAN (30-156): 6.25e-39: 130: 58.27
+	Mm
		1223977 TAL2_MOUSE (149-237): 1.4e-27: 104: 53.85		LMO3_MOUSE (30-156): 6.25e-39: 130: 58.27
+	Mm
		1223978 TAL2_MOUSE (149-237): 1.4e-27: 104: 53.85		RBTN1_MOUSE (20-150): 7.05e-39: 130: 55.73
+	Hs
		682035 TAL2_HUMAN (149-215): 7.29e-27: 102: 67.16		RBTN1_HUMAN (20-150): 3.92e-39: 131: 55.73
+	Dm
		120449 Q9VHG3_DROME (26-234): 1.25e-32: 122: 21.10		M9PD53_DROME (2-86): 8.62e-15: 72.3: 17.44
+	Dm
		1465666 Q9VHG3_DROME (26-234): 1.25e-32: 122: 21.10		Q9V472_DROME (94-155): 8.13e-10: 58: 22.58
+	Hs
		1246449 FIGLA_HUMAN (96-280): 1.37e-29: 113: 26.04		LHX3_HUMAN (92-155): 1.49e-12: 65.7: 23.44
+	Dm
		84289 DIMM_DROME (97-249): 3.56e-28: 113: 21.38		APTE_DROME (90-155): 1.13e-11: 63.4: 19.70
+	Dm
		1477954 Q9W4I4_DROME (148-208): 3.37e-25: 100: 50.82		Q9VJ00_DROME (2-86): 1.18e-14: 71.9: 17.44
+	Hs
		587506 TFE2_HUMAN (18-254): 4.71e-28: 115: 18.60		LMX1A_HUMAN (89-155): 2.26e-09: 56.5: 19.40
+	Dm
		118274 Q9W4I4_DROME (148-208): 3.37e-25: 100: 50.82		M9NCY1_DROME (89-155): 9.64e-10: 57.6: 17.91