HitPredict

Interactor 1: IL2RG (P31785)
Cytokine receptor common subunit gamma (Interleukin-2 receptor subunit gamma) (IL-2 receptor subunit gamma) (IL-2R subunit gamma) (IL-2RG) (gammaC) (p64) (CD antigen CD132)
Gene: IL2RG

Interactor 2: IL2 (P60568)
Interleukin-2 (IL-2) (T-cell growth factor) (TCGF) (Aldesleukin)
Gene: IL2

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.78	0.60	0.687

Property	Details
Experiments	11418623, 8006584, 8568232, 7681595
Identification Methods	affinity chromatography technology, biophysical, protein cross-linking with a bifunctional reagent, anti tag coimmunoprecipitation, pull down
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0006955 - immune response GO:0038110 - interleukin-2-mediated signaling pathway
Homologous interactions	2

Homologous interactions

Color coding for hit scores

	1 369 Hs			1 153
+	Mm
		381342 IL2RG_MOUSE (1-368): 1.08e-98: 299: 70.73		IL2_MOUSE (1-151): 6.75e-71: 212: 57.23
+	Hs
		540458 IL2RB_HUMAN (50-310): 2.24e-37: 143: 19.30		IL2_HUMAN (1-153): 1.29e-80: 236: 100.00