HitPredict

Interactor 1: MP2K1 (P31938)
Dual specificity mitogen-activated protein kinase kinase 1 (MAP kinase kinase 1) (MAPKK 1) (EC 2.7.12.2) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK 1)
Gene: Map2k1

Interactor 2: RAF1 (Q99N57)
RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Proto-oncogene c-RAF) (cRaf) (Raf-1)
Gene: RAF1

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.82 1.00 0.910

The method score is based on:

Property Details
Experiments 14636584, 11435472, 23055494, 8668348, 20956560
Identification Methods affinity chromatography technology, enzymatic study, two hybrid
Interaction Type physical association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains C1_1~Pkinase, Pkinase~Pkinase
Common GO terms GO:0000165 - MAPK cascade
GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0005739 - mitochondrion
and 18 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 393
Mm

1 648
+ Hs
+ Hs
+ Hs
+ Mm
+ Gg
+ Mm
+ Hs
+ Dm
+ Mm
+ Rn
+ Ce
+ Hs
+ At
+ At
+ At
+ Hs
+ Dm
+ Ce
+ Dm
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024