HitPredict

Interactor 1: 1433S (P31947)
14-3-3 protein sigma (Epithelial cell marker protein 1) (Stratifin)
Gene: SFN

Interactor 2: FAK2 (Q14289)
Protein-tyrosine kinase 2-beta (EC 2.7.10.2) (Calcium-dependent tyrosine kinase) (CADTK) (Calcium-regulated non-receptor proline-rich tyrosine kinase) (Cell adhesion kinase beta) (CAK-beta) (CAKB) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Related adhesion focal tyrosine kinase) (RAFTK)
Gene: PTK2B

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	36931259
Identification Methods	cross-linking study
Interaction Type	physical association

Property	Details
Interacting Pfam domains	14-3-3~PK_Tyr_Ser-Thr
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0007165 - signal transduction GO:0030307 - positive regulation of cell growth
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 248 Hs			1 1009
+	Hs
		909560 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		FAK2_HUMAN (1-1009): 0: 1064: 100.00
+	Hs
		337367 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		ABL1_HUMAN (264-885): 2.55e-133: 432: 23.56
+	Hs
		684051 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		ERBB4_HUMAN (240-925): 9.44e-128: 421: 22.59
+	Hs
		683884 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		ABL2_HUMAN (222-877): 3.65e-126: 414: 22.85
+	Hs
		383641 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		ERBB2_HUMAN (286-908): 2.13e-124: 411: 21.96
+	At
		1277300 14337_ARATH (2-247): 4.35e-147: 413: 58.07		SERK1_ARATH (221-719): 5.75e-141: 437: 16.38
+	Hs
		337416 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		ABL1_HUMAN (264-885): 2.55e-133: 432: 23.56
+	At
		965320 14332_ARATH (3-248): 2.23e-144: 405: 58.47		BAK1_ARATH (200-700): 1.61e-140: 436: 16.70
+	Hs
		909589 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		ERBB4_HUMAN (240-925): 9.44e-128: 421: 22.59
+	Hs
		411616 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		LCK_HUMAN (208-694): 1.45e-123: 387: 27.18
+	Hs
		789053 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		ABL2_HUMAN (222-877): 3.65e-126: 414: 22.85
+	Hs
		383724 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		ERBB2_HUMAN (286-908): 2.13e-124: 411: 21.96
+	Hs
		337420 1433Z_HUMAN (1-243): 5.4e-136: 384: 70.37		ABL1_HUMAN (264-885): 2.55e-133: 432: 23.56
+	Hs
		789056 1433Z_HUMAN (1-243): 5.4e-136: 384: 70.37		ABL2_HUMAN (222-877): 3.65e-126: 414: 22.85
+	Hs
		411661 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		LCK_HUMAN (208-694): 1.45e-123: 387: 27.18
+	Hs
		383732 1433Z_HUMAN (1-243): 5.4e-136: 384: 70.37		ERBB2_HUMAN (286-908): 2.13e-124: 411: 21.96
+	Hs
		411666 1433Z_HUMAN (1-243): 5.4e-136: 384: 70.37		LCK_HUMAN (208-694): 1.45e-123: 387: 27.18
+	Hs
		337355 1433T_HUMAN (1-238): 9.98e-108: 312: 71.85		ABL1_HUMAN (264-885): 2.55e-133: 432: 23.56
+	Hs
		383624 1433T_HUMAN (1-238): 9.98e-108: 312: 71.85		ERBB2_HUMAN (286-908): 2.13e-124: 411: 21.96
+	Hs
		411605 1433T_HUMAN (1-238): 9.98e-108: 312: 71.85		LCK_HUMAN (208-694): 1.45e-123: 387: 27.18