Interactor 1: FCG2B (P31994)
Low affinity immunoglobulin gamma Fc region receptor II-b (IgG Fc receptor II-b) (CDw32) (Fc-gamma RII-b) (Fc-gamma-RIIb) (FcRII-b) (CD antigen CD32)
Gene: FCGR2B

Interactor 2: SHIP1 (Q92835)
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 (EC 3.1.3.86) (Inositol polyphosphate-5-phosphatase D) (EC 3.1.3.56) (Inositol polyphosphate-5-phosphatase of 145 kDa) (SIP-145) (Phosphatidylinositol 4,5-bisphosphate 5-phosphatase) (EC 3.1.3.36) (SH2 domain-containing inositol 5'-phosphatase 1) (SH2 domain-containing inositol phosphatase 1) (SHIP-1) (p150Ship) (hp51CN)
Gene: INPP5D

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.79 0.60 0.692

The method score is based on:

Property Details
Experiments 11453982, 9232445, 24642916, 10382761, 9148918
Identification Methods unspecified method, surface plasmon resonance, pull down, affinity chromatography technology
Interaction Type direct interaction, association, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0005886 - plasma membrane
GO:0016064 - immunoglobulin mediated immune response
GO:0030889 - negative regulation of B cell proliferation
GO:0050777 - negative regulation of immune response
Homologous interactions 7

Homologous interactions

Color coding for hit scores

1 310
Hs

1 1189
+ Hs
+ Mm
+ Hs
+ Rn
+ Mm
+ Hs
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024