HitPredict

Interactor 1: 1433T (P27348)
14-3-3 protein theta (14-3-3 protein T-cell) (14-3-3 protein tau) (Protein HS1)
Gene: YWHAQ

Interactor 2: TESK2 (Q96S53)
Dual specificity testis-specific protein kinase 2 (EC 2.7.12.1) (Testicular protein kinase 2)
Gene: TESK2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.85	1.00	0.925

Property	Details
Experiments	32707033, 33961781, 36931259, 28514442, unassigned3799
Identification Methods	affinity chromatography technology, proximity labelling technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	14-3-3~PK_Tyr_Ser-Thr
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 245 Hs			1 571
+	Hs
		971911 1433E_HUMAN (2-243): 1.32e-144: 406: 63.53		TESK2_HUMAN (1-571): 5.82e-163: 477: 100.00
+	Hs
		990634 1433Z_HUMAN (1-245): 1.76e-141: 397: 79.59		TESK2_HUMAN (1-571): 5.82e-163: 477: 100.00
+	Hs
		730173 1433B_HUMAN (1-242): 5.04e-139: 391: 81.82		TESK2_HUMAN (1-571): 5.82e-163: 477: 100.00
+	At
		1030880 14332_ARATH (3-243): 8.69e-144: 404: 61.22		PBS1_ARATH (6-401): 1.44e-132: 396: 21.45
+	Hs
		971556 1433E_HUMAN (2-243): 1.32e-144: 406: 63.53		TESK1_HUMAN (41-558): 3.06e-126: 385: 47.62
+	Hs
		730846 1433S_HUMAN (1-236): 9.9e-108: 312: 71.85		TESK2_HUMAN (1-571): 5.82e-163: 477: 100.00
+	Hs
		1049696 1433F_HUMAN (2-242): 7.19e-106: 307: 71.43		TESK2_HUMAN (1-571): 5.82e-163: 477: 100.00
+	At
		1030873 14332_ARATH (3-243): 8.69e-144: 404: 61.22		BAK1_ARATH (14-356): 1.58e-122: 375: 23.14
+	At
		840383 14333_ARATH (3-243): 8.04e-143: 401: 61.63		PBL9_ARATH (15-314): 2.5e-126: 378: 23.35
+	Hs
		729861 1433B_HUMAN (1-242): 5.04e-139: 391: 81.82		TESK1_HUMAN (41-558): 3.06e-126: 385: 47.62
+	Hs
		971456 1433E_HUMAN (2-243): 1.32e-144: 406: 63.53		MERTK_HUMAN (61-437): 2.03e-100: 328: 25.00
+	Hs
		690954 1433T_HUMAN (1-245): 9.51e-142: 398: 100.00		MERTK_HUMAN (61-437): 2.03e-100: 328: 25.00
+	Hs
		729787 1433B_HUMAN (1-242): 5.04e-139: 391: 81.82		MERTK_HUMAN (61-437): 2.03e-100: 328: 25.00
+	Hs
		730605 1433S_HUMAN (1-236): 9.9e-108: 312: 71.85		TESK1_HUMAN (41-558): 3.06e-126: 385: 47.62
+	Hs
		1049317 1433F_HUMAN (2-242): 7.19e-106: 307: 71.43		TESK1_HUMAN (41-558): 3.06e-126: 385: 47.62
+	Hs
		922241 1433E_HUMAN (2-243): 1.32e-144: 406: 63.53		LIMK1_HUMAN (62-312): 5.58e-66: 228: 44.40
+	Hs
		922242 1433Z_HUMAN (1-245): 1.76e-141: 397: 79.59		LIMK1_HUMAN (62-312): 5.58e-66: 228: 44.40
+	Hs
		922299 1433E_HUMAN (2-243): 1.32e-144: 406: 63.53		LIMK2_HUMAN (62-318): 8.88e-61: 214: 40.86
+	Hs
		730463 1433S_HUMAN (1-236): 9.9e-108: 312: 71.85		LIMK1_HUMAN (62-312): 5.58e-66: 228: 44.40
+	Hs
		730464 1433S_HUMAN (1-236): 9.9e-108: 312: 71.85		LIMK2_HUMAN (62-318): 8.88e-61: 214: 40.86