Protein: TESK2
Dual specificity testis-specific protein kinase 2 (EC 2.7.12.1) (Testicular protein kinase 2)

Gene: TESK2
Organism: Homo sapiens
Interactions: 100
UniProt ID: Q96S53

Gene Ontology (top 5):
GO:0004672 - protein kinase activity
GO:0004674 - protein serine/threonine kinase activity
GO:0004712 - protein serine/threonine/tyrosine kinase activity
GO:0004713 - protein tyrosine kinase activity
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

730173

1433B
14-3-3 protein beta/alpha

6

20

Small-scale

0.940

High

691358

1433T
14-3-3 protein theta

5

20

High-throughput

0.925

High

966779

1433G
14-3-3 protein gamma

4

20

High-throughput

0.903

High

1049696

1433F
14-3-3 protein eta

4

20

High-throughput

0.903

High

971911

1433E
14-3-3 protein epsilon

3

7

High-throughput

0.867

High

990634

1433Z
14-3-3 protein zeta/delta

3

20

High-throughput

0.861

High

461843

HS90A
Heat shock protein HSP 90-alpha

3

17

High-throughput

0.847

High

468716

HS90B
Heat shock protein HSP 90-beta

2

18

High-throughput

0.802

High

1106051

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

2

5

High-throughput

0.789

High

1158489

CDC37
Hsp90 co-chaperone Cdc37

2

5

High-throughput

0.789

High

1202066

HS905
Putative heat shock protein HSP 90-alpha A5

2

20

High-throughput

0.737

High

1150284

TESK1
Dual specificity testis-specific protein kinase 1

1

15

High-throughput

0.691

High

176868

DCLK1
Serine/threonine-protein kinase DCLK1

1

2

High-throughput

0.618

High

245261

MAST3
Microtubule-associated serine/threonine-protein kinase 3

1

2

High-throughput

0.618

High

269602

SRGP2
SLIT-ROBO Rho GTPase-activating protein 2

1

2

High-throughput

0.618

High

730846

1433S
14-3-3 protein sigma

1

20

High-throughput

0.618

High

1025586

CDK16
Cyclin-dependent kinase 16

1

12

High-throughput

0.618

High

1129973

MELK
Maternal embryonic leucine zipper kinase

1

5

High-throughput

0.618

High

1152031

PTN14
Tyrosine-protein phosphatase non-receptor type 14

1

2

High-throughput

0.618

High

1216018

M3K21
Mitogen-activated protein kinase kinase kinase 21

1

13

High-throughput

0.618

High

1216084

SPD2A
SH3 and PX domain-containing protein 2A

1

5

High-throughput

0.618

High

1234915

PKHA7
Pleckstrin homology domain-containing family A member 7

1

5

High-throughput

0.618

High

1245570

Q6PK50
HSP90AB1 protein

1

18

High-throughput

0.618

High

1309237

KSR1
Kinase suppressor of Ras 1

1

19

High-throughput

0.618

High

1402216

PKHA5
Pleckstrin homology domain-containing family A member 5

1

7

High-throughput

0.618

High

1402230

GAB2
GRB2-associated-binding protein 2

1

4

High-throughput

0.618

High

1402221

SH3B4
SH3 domain-binding protein 4

1

0

High-throughput

0.586

High

1202004

H90B4
Putative heat shock protein HSP 90-beta 4

1

17

High-throughput

0.575

High

1202041

H90B2
Putative heat shock protein HSP 90-beta 2

1

20

High-throughput

0.575

High

1092480

TIAM1
Rho guanine nucleotide exchange factor TIAM1

1

5

High-throughput

0.553

High

1352630

SH3R3
E3 ubiquitin-protein ligase SH3RF3

1

7

High-throughput

0.553

High

1402222

LRFN1
Leucine-rich repeat and fibronectin type III domain-containing protein 1

1

2

High-throughput

0.553

High

1402229

AGAP1
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1

1

2

High-throughput

0.553

High

138938

USP9Y
Ubiquitin carboxyl-terminal hydrolase 9Y

1

1

High-throughput

0.536

High

165078

RPC1
DNA-directed RNA polymerase III subunit RPC1

1

1

High-throughput

0.536

High

325992

UBR5
E3 ubiquitin-protein ligase UBR5

1

3

High-throughput

0.536

High

697625

PYR1
Multifunctional protein CAD

1

2

High-throughput

0.536

High

723060

RPB2
DNA-directed RNA polymerase II subunit RPB2

1

2

High-throughput

0.536

High

1365734

GCN1
Stalled ribosome sensor GCN1

1

2

High-throughput

0.536

High

1402232

SGT1
Protein SGT1 homolog

1

1

High-throughput

0.536

High

1286534

PHLB2
Pleckstrin homology-like domain family B member 2

1

0

High-throughput

0.517

High

1402213

RTKN
Rhotekin

1

0

High-throughput

0.517

High

1315948

CHSS2
Chondroitin sulfate synthase 2

1

0

High-throughput

0.513

High

1402217

CYBP
Calcyclin-binding protein

1

0

High-throughput

0.513

High

50674

HACL2
2-hydroxyacyl-CoA lyase 2

1

1

High-throughput

0.489

High

337012

AHSA1
Activator of 90 kDa heat shock protein ATPase homolog 1

1

1

High-throughput

0.489

High

230562

KIF1C
Kinesin-like protein KIF1C

1

1

High-throughput

0.479

High

637942

NF1
Neurofibromin

1

3

High-throughput

0.479

High

719257

MPIP2
M-phase inducer phosphatase 2

1

1

High-throughput

0.479

High

719363

MPIP3
M-phase inducer phosphatase 3

1

1

High-throughput

0.479

High

936421

AFAD
Afadin

1

6

High-throughput

0.479

High

941046

HDAC4
Histone deacetylase 4

1

2

High-throughput

0.479

High

1014181

CBX1
Chromobox protein homolog 1

1

1

High-throughput

0.479

High

1257035

SYDE1
Rho GTPase-activating protein SYDE1

1

4

High-throughput

0.479

High

1277706

MYCPP
C-myc promoter-binding protein

1

3

High-throughput

0.479

High

1338100

NAV1
Neuron navigator 1

1

1

High-throughput

0.479

High

1356758

HDAC7
Histone deacetylase 7

1

2

High-throughput

0.479

High

1360392

SRS12
Serine/arginine-rich splicing factor 12

1

2

High-throughput

0.479

High

1384528

Q96BE0
Heat shock cognate 71 kDa protein

1

3

High-throughput

0.479

High

1401102

MAGI1
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1

1

5

High-throughput

0.479

High

1402211

F110A
Protein FAM110A

1

1

High-throughput

0.479

High

1402218

KI13B
Kinesin-like protein KIF13B

1

1

High-throughput

0.479

High

1402224

LIMA1
LIM domain and actin-binding protein 1

1

2

High-throughput

0.479

High

1402228

PPM1H
Protein phosphatase 1H

1

2

High-throughput

0.479

High

1402234

STA13
StAR-related lipid transfer protein 13

1

2

High-throughput

0.479

High

208723

SI1L1
Signal-induced proliferation-associated 1-like protein 1

1

0

High-throughput

0.458

High

252144

IF4E2
Eukaryotic translation initiation factor 4E type 2

1

0

High-throughput

0.458

High

339100

NADK
NAD kinase

1

0

High-throughput

0.458

High

1134037

ZN638
Zinc finger protein 638

1

0

High-throughput

0.458

High

1245707

LARP1
La-related protein 1

1

0

High-throughput

0.458

High

1322634

RPTOR
Regulatory-associated protein of mTOR

1

0

High-throughput

0.458

High

1400857

RAB3I
Rab-3A-interacting protein

1

0

High-throughput

0.458

High

1402210

SIN1
Target of rapamycin complex 2 subunit MAPKAP1

1

0

High-throughput

0.458

High

1402212

LPIN3
Phosphatidate phosphatase LPIN3

1

0

High-throughput

0.458

High

1402219

INP5E
Phosphatidylinositol polyphosphate 5-phosphatase type IV

1

0

High-throughput

0.458

High

1402220

FA53C
Protein FAM53C

1

0

High-throughput

0.458

High

1402226

UBP21
Ubiquitin carboxyl-terminal hydrolase 21

1

0

High-throughput

0.458

High

1402227

ZBT21
Zinc finger and BTB domain-containing protein 21

1

0

High-throughput

0.458

High

1402231

ZBTB1
Zinc finger and BTB domain-containing protein 1

1

0

Small-scale

0.458

High

1402233

CBY1
Protein chibby homolog 1

1

0

High-throughput

0.458

High

1402236

EID1
EP300-interacting inhibitor of differentiation 1

1

0

Small-scale

0.458

High

839496

PI4KA
Phosphatidylinositol 4-kinase alpha

1

5

High-throughput

0.445

High

1258554

CR3L2
Cyclic AMP-responsive element-binding protein 3-like protein 2

1

1

High-throughput

0.445

High

281397

GGYF1
GRB10-interacting GYF protein 1

1

1

High-throughput

0.437

High

1065752

CAMP2
Calmodulin-regulated spectrin-associated protein 2

1

1

High-throughput

0.437

High

1187130

TBC25
TBC1 domain family member 25

1

4

High-throughput

0.437

High

1195684

Q4LE69
Phosphatidylinositol 4-kinase alpha

1

5

High-throughput

0.437

High

1219612

DEN4C
DENN domain-containing protein 4C

1

3

High-throughput

0.437

High

1229899

AN34A
Ankyrin repeat domain-containing protein 34A

1

4

High-throughput

0.437

High

1251414

GGYF2
GRB10-interacting GYF protein 2

1

6

High-throughput

0.437

High

1349470

F110B
Protein FAM110B

1

1

High-throughput

0.437

High

1352602

DEN1A
DENN domain-containing protein 1A

1

3

High-throughput

0.437

High

1357411

DEP1B
DEP domain-containing protein 1B

1

2

High-throughput

0.437

High

1402225

NGAP
Ras GTPase-activating protein nGAP

1

3

High-throughput

0.437

High

160588

IRS4
Insulin receptor substrate 4

1

0

High-throughput

0.279

Low

1402214

CPVL
Probable serine carboxypeptidase CPVL

1

0

High-throughput

0.279

Low

1402215

CPLN1
Ciliogenesis and planar polarity effector 1

1

0

High-throughput

0.279

Low

1390400

EDC3
Enhancer of mRNA-decapping protein 3

1

0

High-throughput

0.249

Low

1402223

CING
Cingulin

1

0

High-throughput

0.249

Low

1402235

KCTD3
BTB/POZ domain-containing protein KCTD3

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025