HitPredict

Interactor 1: RFA1 (P27694)
Replication protein A 70 kDa DNA-binding subunit (RP-A p70) (Replication factor A protein 1) (RF-A protein 1) (Single-stranded DNA-binding protein) [Cleaved into: Replication protein A 70 kDa DNA-binding subunit, N-terminally processed]
Gene: RPA1

Interactor 2: BRE1A (Q5VTR2)
E3 ubiquitin-protein ligase BRE1A (BRE1-A) (hBRE1) (EC 2.3.2.27) (RING finger protein 20) (RING-type E3 ubiquitin transferase BRE1A)
Gene: RNF20

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.52	0.60	0.561

Property	Details
Experiments	37155876
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003682 - chromatin binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0008270 - zinc ion binding
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 616 Hs			1 975
+	Hs
		272617 RFA1_HUMAN (1-616): 0: 781: 100.00		BRE1B_HUMAN (1-974): 2.16e-60: 225: 56.09
+	Hs
		694773 RFA1_HUMAN (1-616): 0: 781: 100.00		MYH11_HUMAN (561-933): 5.95e-14: 79: 10.46
+	Hs
		694763 RFA1_HUMAN (1-616): 0: 781: 100.00		MYH9_HUMAN (561-959): 1.37e-13: 77.5: 9.59
+	Hs
		694764 RFA1_HUMAN (1-616): 0: 781: 100.00		MYH10_HUMAN (1-355): 1.6e-13: 77.5: 9.47
+	Hs
		587563 RFA1_HUMAN (1-616): 0: 781: 100.00		DESP_HUMAN (225-919): 9.05e-12: 71.9: 16.12
+	Hs
		696090 RFA1_HUMAN (1-616): 0: 781: 100.00		MY18A_HUMAN (326-919): 1.43e-10: 67.7: 15.69
+	Hs
		696344 RFA1_HUMAN (1-616): 0: 781: 100.00		FYCO1_HUMAN (70-921): 5.81e-09: 62.3: 14.87
+	Sc
		647846 RFA1_YEAST (4-615): 0: 596: 31.69		BRE1_YEAST (509-974): 2.64e-58: 215: 19.14