HitPredict

Interactor 1: CALR (P27797)
Calreticulin (CRP55) (Calregulin) (Endoplasmic reticulum resident protein 60) (ERp60) (HACBP) (grp60)
Gene: CALR

Interactor 2: PDIA3 (P30101)
Protein disulfide-isomerase A3 (EC 5.3.4.1) (58 kDa glucose-regulated protein) (58 kDa microsomal protein) (p58) (Disulfide isomerase ER-60) (Endoplasmic reticulum resident protein 57) (ER protein 57) (ERp57) (Endoplasmic reticulum resident protein 60) (ER protein 60) (ERp60)
Gene: PDIA3

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.93 1.00 0.967

The method score is based on:

Property Details
Experiments 11823531, 10436013, 24981860, 30021884, 37071682, 40437099, 12052826
Identification Methods affinity chromatography technology, biochemical, pull down, proximity labelling technology, cross-linking study
Interaction Type physical association, association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains Calreticulin~Thioredoxin_6
Common GO terms GO:0002502 - peptide antigen assembly with MHC class I protein complex
GO:0003723 - RNA binding
GO:0005615 - extracellular space
GO:0005634 - nucleus
GO:0005783 - endoplasmic reticulum
and 7 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 417
Hs

1 505
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Last updated: 11Aug2025