HitPredict

Interactor 1: CALR (P29413)
Calreticulin
Gene: CALR

Interactor 2: PDIA6 (Q9V438)
Protein disulfide-isomerase A6 homolog (EC 5.3.4.1) (Calcium-binding protein 1) (DmCaBP1)
Gene: CaBP1

Species: Drosophila melanogaster

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.571

Property	Details
Experiments	22036573, 38944040
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005788 - endoplasmic reticulum lumen GO:0012505 - endomembrane system
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 406 Dm			1 433
+	Hs
		697886 CALR_HUMAN (21-361): 1.74e-163: 467: 71.72		PDIA6_HUMAN (1-433): 2.04e-117: 351: 57.21
+	Hs
		1142366 CALR3_HUMAN (11-361): 7.06e-154: 441: 43.06		PDIA6_HUMAN (1-433): 2.04e-117: 351: 57.21
+	Hs
		698008 CALR_HUMAN (21-361): 1.74e-163: 467: 71.72		ERP44_HUMAN (11-433): 3.53e-63: 210: 17.39
+	Hs
		1127935 CALR3_HUMAN (11-361): 7.06e-154: 441: 43.06		PDIA5_HUMAN (2-399): 5.52e-67: 224: 22.30
+	Hs
		1396535 CALR3_HUMAN (11-361): 7.06e-154: 441: 43.06		ERP44_HUMAN (11-433): 3.53e-63: 210: 17.39
+	Dm
		712329 CALR_DROME (1-406): 0: 545: 100.00		PDI_DROME (62-383): 9.65e-13: 71.9: 11.47
+	At
		146277 CALR1_ARATH (8-358): 5.33e-152: 438: 53.67		PDI21_ARATH (15-206): 2.27e-32: 127: 28.35
+	Hs
		697944 CALR_HUMAN (21-361): 1.74e-163: 467: 71.72		DJC10_HUMAN (25-377): 8.9e-20: 94.2: 18.61
+	Hs
		1334116 CALR3_HUMAN (11-361): 7.06e-154: 441: 43.06		TXND5_HUMAN (13-134): 5.74e-28: 116: 29.60
+	Hs
		697777 CALR_HUMAN (21-361): 1.74e-163: 467: 71.72		PDIA3_HUMAN (106-286): 9.99e-18: 87.3: 27.87
+	Hs
		697992 CALR_HUMAN (21-361): 1.74e-163: 467: 71.72		TMX3_HUMAN (1-127): 7.75e-17: 84.3: 36.15
+	Hs
		697864 CALR_HUMAN (21-361): 1.74e-163: 467: 71.72		PDIA2_HUMAN (119-383): 1.74e-12: 71.1: 13.48
+	Hs
		1312041 CALR3_HUMAN (11-361): 7.06e-154: 441: 43.06		DJC10_HUMAN (25-377): 8.9e-20: 94.2: 18.61
+	Hs
		717574 CALR3_HUMAN (11-361): 7.06e-154: 441: 43.06		PDIA3_HUMAN (106-286): 9.99e-18: 87.3: 27.87
+	Hs
		566560 CALR_HUMAN (21-361): 1.74e-163: 467: 71.72		PDIA4_HUMAN (179-384): 7.27e-09: 59.9: 9.96
+	Hs
		452369 CALR3_HUMAN (11-361): 7.06e-154: 441: 43.06		PDIA1_HUMAN (62-383): 5.82e-11: 66.1: 11.44
+	Hs
		566803 CALR3_HUMAN (11-361): 7.06e-154: 441: 43.06		PDIA4_HUMAN (179-384): 7.27e-09: 59.9: 9.96
+	Hs
		698415 CALX_HUMAN (18-353): 2.1e-129: 386: 34.42		PDIA3_HUMAN (106-286): 9.99e-18: 87.3: 27.87
+	Hs
		452173 CALX_HUMAN (18-353): 2.1e-129: 386: 34.42		PDIA1_HUMAN (62-383): 5.82e-11: 66.1: 11.44
+	Hs
		566561 CALX_HUMAN (18-353): 2.1e-129: 386: 34.42		PDIA4_HUMAN (179-384): 7.27e-09: 59.9: 9.96