HitPredict

Interactor 1: P85A (P27986)
Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase regulatory subunit alpha) (PI3K regulatory subunit alpha) (PtdIns-3-kinase regulatory subunit alpha) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha) (PI3-kinase subunit p85-alpha) (PtdIns-3-kinase regulatory subunit p85-alpha)
Gene: PIK3R1

Interactor 2: RRAS2 (P62070)
Ras-related protein R-Ras2 (EC 3.6.5.2) (Ras-like protein TC21) (Teratocarcinoma oncogene)
Gene: RRAS2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	11850823
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Ras~RhoGAP
Common GO terms	GO:0005886 - plasma membrane GO:0016020 - membrane
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 724 Hs			1 204
+	Hs
		699757 P85A_HUMAN (1-724): 0: 590: 100.00		RAB35_HUMAN (10-200): 4.47e-84: 249: 27.50
+	Hs
		520676 P85A_HUMAN (1-724): 0: 590: 100.00		RRAS_HUMAN (13-204): 2.24e-81: 243: 67.71
+	Hs
		374417 P85A_HUMAN (1-724): 0: 590: 100.00		RASH_HUMAN (14-203): 8.9e-57: 179: 55.26
+	Mm
		686969 P85A_MOUSE (1-724): 0: 585: 95.99		RASH_MOUSE (14-203): 8.9e-57: 179: 55.26
+	Hs
		375202 P85A_HUMAN (1-724): 0: 590: 100.00		RASK_HUMAN (14-199): 3.16e-54: 172: 54.84
+	Hs
		136388 P85B_HUMAN (4-719): 2.94e-159: 479: 57.24		RAB35_HUMAN (10-200): 4.47e-84: 249: 27.50
+	Hs
		136244 P85B_HUMAN (4-719): 2.94e-159: 479: 57.24		RASK_HUMAN (14-199): 3.16e-54: 172: 54.84
+	Hs
		1145042 P55G_HUMAN (271-723): 2.98e-104: 328: 72.31		RAB35_HUMAN (10-200): 4.47e-84: 249: 27.50
+	Hs
		976458 P55G_HUMAN (271-723): 2.98e-104: 328: 72.31		RB11A_HUMAN (4-202): 5.07e-78: 234: 25.70
+	Hs
		1144945 RHG21_HUMAN (78-531): 1.5e-60: 223: 12.63		RAB35_HUMAN (10-200): 4.47e-84: 249: 27.50
+	Hs
		67671 RHG32_HUMAN (14-356): 8.12e-56: 209: 17.71		RAB35_HUMAN (10-200): 4.47e-84: 249: 27.50
+	Hs
		1324054 RHG24_HUMAN (67-634): 8.03e-62: 222: 13.35		RIT2_HUMAN (11-195): 7.82e-58: 182: 52.43
+	Hs
		374664 RHG21_HUMAN (78-531): 1.5e-60: 223: 12.63		RASH_HUMAN (14-203): 8.9e-57: 179: 55.26
+	Hs
		375594 RHG21_HUMAN (78-531): 1.5e-60: 223: 12.63		RASK_HUMAN (14-199): 3.16e-54: 172: 54.84
+	Hs
		269497 SRGP2_HUMAN (118-668): 6.27e-59: 217: 13.38		RASK_HUMAN (14-199): 3.16e-54: 172: 54.84
+	Hs
		67597 RHG32_HUMAN (14-356): 8.12e-56: 209: 17.71		RASK_HUMAN (14-199): 3.16e-54: 172: 54.84
+	Hs
		374650 RHG29_HUMAN (102-637): 1.75e-52: 199: 12.88		RASH_HUMAN (14-203): 8.9e-57: 179: 55.26