HitPredict

Interactor 1: PSA5 (P28066)
Proteasome subunit alpha type-5 (Macropain zeta chain) (Multicatalytic endopeptidase complex zeta chain) (Proteasome subunit alpha-5) (alpha-5) (Proteasome zeta chain)
Gene: PSMA5

Interactor 2: PSME4 (Q14997)
Proteasome activator complex subunit 4 (Proteasome activator PA200) (Protein BLM10 homolog) (Blm10) (hBlm10)
Gene: PSME4

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.79	1.00	0.892

Property	Details
Experiments	35271311, 37217651, 33961781, unassigned3799
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	BLM10_mid~Proteasome, DUF3437~Proteasome, BLM10_mid~Proteasome_A_N, DUF3437~Proteasome_A_N
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 241 Hs			1 1843
+	Hs
		165329 PSA7_HUMAN (8-239): 5.33e-89: 265: 36.17		PSME4_HUMAN (1-1843): 0: 2463: 100.00
+	Hs
		680875 PSA1_HUMAN (3-241): 7.76e-89: 265: 28.81		PSME4_HUMAN (1-1843): 0: 2463: 100.00
+	Hs
		681165 PSA2_HUMAN (3-241): 2.39e-89: 265: 30.96		PSME4_HUMAN (1-1843): 0: 2463: 100.00
+	Hs
		954811 PSA6_HUMAN (4-241): 1.52e-88: 263: 25.93		PSME4_HUMAN (1-1843): 0: 2463: 100.00
+	Sc
		735938 PSA5_YEAST (1-241): 5.66e-95: 280: 60.49		BLM10_YEAST (74-831): 0: 722: 16.61
+	Sc
		661418 PSA3_YEAST (8-238): 3.61e-44: 150: 36.40		BLM10_YEAST (74-831): 0: 722: 16.61