Protein: PSME4
Proteasome activator complex subunit 4 (Proteasome activator PA200) (Protein BLM10 homolog) (Blm10) (hBlm10)

Gene: PSME4
Organism: Homo sapiens
Interactions: 87
UniProt ID: Q14997

Gene Ontology (top 5):
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005829 - cytosol
GO:0006281 - DNA repair
GO:0006974 - DNA damage response

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

680875

PSA1
Proteasome subunit alpha type-1

5

5

Small-scale

0.927

High

1134875

PSB7
Proteasome subunit beta type-7

5

11

High-throughput

0.925

High

887655

PSB2
Proteasome subunit beta type-2

4

12

Small-scale

0.900

High

681165

PSA2
Proteasome subunit alpha type-2

4

8

Small-scale

0.895

High

700519

PSB9
Proteasome subunit beta type-9

4

12

Small-scale

0.895

High

700885

PSB4
Proteasome subunit beta type-4

4

13

High-throughput

0.895

High

700636

PSA5
Proteasome subunit alpha type-5

4

6

Small-scale

0.892

High

633681

PSB1
Proteasome subunit beta type-1

3

13

High-throughput

0.871

High

887530

PSB3
Proteasome subunit beta type-3

3

11

High-throughput

0.871

High

165329

PSA7
Proteasome subunit alpha type-7

3

5

Small-scale

0.861

High

681647

PSA4
Proteasome subunit alpha type-4

3

8

Small-scale

0.861

High

701152

PSB5
Proteasome subunit beta type-5

3

12

Small-scale

0.861

High

700460

PSB8
Proteasome subunit beta type-8

3

12

Small-scale

0.839

High

681371

PSA3
Proteasome subunit alpha type-3

2

7

Small-scale

0.789

High

701030

PSB6
Proteasome subunit beta type-6

2

14

Small-scale

0.789

High

954811

PSA6
Proteasome subunit alpha type-6

2

8

Small-scale

0.789

High

138113

PSDE
26S proteasome non-ATPase regulatory subunit 14

3

2

Small-scale

0.640

High

822145

PSB10
Proteasome subunit beta type-10

1

11

Small-scale

0.618

High

1134856

PSME4
Proteasome activator complex subunit 4

1

1

High-throughput

0.618

High

127960

PSD11
26S proteasome non-ATPase regulatory subunit 11

2

2

Small-scale

0.611

High

975401

PRS10
26S proteasome regulatory subunit 10B

2

6

Small-scale

0.611

High

571766

FPPS
Farnesyl pyrophosphate synthase

2

0

High-throughput

0.602

High

1134877

SLX1
Structure-specific endonuclease subunit SLX1

2

0

High-throughput

0.602

High

372055

MYC
Myc proto-oncogene protein

2

0

High-throughput

0.585

High

933640

PSMD4
26S proteasome non-ATPase regulatory subunit 4

2

0

High-throughput

0.585

High

1054586

PSME1
Proteasome activator complex subunit 1

2

0

Small-scale

0.585

High

1134884

UCHL5
Ubiquitin carboxyl-terminal hydrolase isozyme L5

2

0

Small-scale

0.585

High

1050421

UBE3A
Ubiquitin-protein ligase E3A

2

1

Small-scale

0.584

High

979673

H4
Histone H4

2

0

Small-scale

0.582

High

954691

SEM1
26S proteasome complex subunit SEM1

2

0

Small-scale

0.576

High

114601

H0YKT8
Proteasome subunit beta

1

8

High-throughput

0.575

High

1095637

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

1

0

High-throughput

0.549

High

1134868

NUTM1
NUT family member 1

1

0

High-throughput

0.549

High

128230

PSD12
26S proteasome non-ATPase regulatory subunit 12

1

2

High-throughput

0.536

High

610329

PRS6A
26S proteasome regulatory subunit 6A

1

7

High-throughput

0.536

High

778681

PRS7
26S proteasome regulatory subunit 7

1

5

High-throughput

0.536

High

851320

PRS6B
26S proteasome regulatory subunit 6B

1

4

High-throughput

0.536

High

968703

PRS4
26S proteasome regulatory subunit 4

1

5

High-throughput

0.536

High

968919

PRS8
26S proteasome regulatory subunit 8

1

6

High-throughput

0.536

High

1097982

PSMD2
26S proteasome non-ATPase regulatory subunit 2

1

4

High-throughput

0.536

High

1134857

PSMD6
26S proteasome non-ATPase regulatory subunit 6

1

1

High-throughput

0.536

High

1134871

CSN5
COP9 signalosome complex subunit 5

1

2

High-throughput

0.536

High

1134876

PSMD1
26S proteasome non-ATPase regulatory subunit 1

1

4

High-throughput

0.536

High

1134883

PSD13
26S proteasome non-ATPase regulatory subunit 13

1

1

High-throughput

0.536

High

210945

PSMD3
26S proteasome non-ATPase regulatory subunit 3

1

0

High-throughput

0.513

High

337470

PSMG1
Proteasome assembly chaperone 1

1

0

High-throughput

0.513

High

725019

HXA13
Homeobox protein Hox-A13

1

0

High-throughput

0.513

High

1134860

KYNU
Kynureninase

1

0

High-throughput

0.513

High

1134865

BAKOR
Beclin 1-associated autophagy-related key regulator

1

0

High-throughput

0.513

High

1134872

ISL2
Insulin gene enhancer protein ISL-2

1

0

High-throughput

0.513

High

1134881

TF3C4
General transcription factor 3C polypeptide 4

1

0

High-throughput

0.513

High

1134882

AMFR
E3 ubiquitin-protein ligase AMFR

1

0

High-throughput

0.513

High

1134858

UBE3C
Ubiquitin-protein ligase E3C

1

1

High-throughput

0.489

High

843567

HD
Huntingtin

1

0

Small-scale

0.480

High

241707

PRKN
E3 ubiquitin-protein ligase parkin

1

1

High-throughput

0.479

High

931518

RD23A
UV excision repair protein RAD23 homolog A

1

1

Small-scale

0.479

High

1134879

FXL17
F-box/LRR-repeat protein 17

1

0

Small-scale

0.460

High

320680

UBXN7
UBX domain-containing protein 7

1

0

High-throughput

0.458

High

695482

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

768217

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.458

High

1096689

RFA4
Replication protein A 30 kDa subunit

1

0

High-throughput

0.458

High

1106541

SMAD4
Mothers against decapentaplegic homolog 4

1

0

High-throughput

0.458

High

1114826

CUL4A
Cullin-4A

1

0

High-throughput

0.458

High

1134859

ADRM1
Proteasomal ubiquitin receptor ADRM1

1

0

High-throughput

0.458

High

1134874

CI072
Guanine nucleotide exchange factor C9orf72

1

0

High-throughput

0.458

High

1134880

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

271526

ATG13
Autophagy-related protein 13

1

0

High-throughput

0.426

High

429909

JUN
Transcription factor Jun

1

0

High-throughput

0.426

High

704

A0A087WW66
26S proteasome non-ATPase regulatory subunit 1

1

4

High-throughput

0.407

High

97079

E9PMD8
Proteasome 26S subunit, ATPase 3

1

6

High-throughput

0.407

High

407003

A1BG
Alpha-1B-glycoprotein

2

0

High-throughput

0.328

High

1134861

TAF7L
Transcription initiation factor TFIID subunit 7-like

2

0

High-throughput

0.328

High

1134864

KLH10
Kelch-like protein 10

2

0

High-throughput

0.328

High

477334

NMB
Neuromedin-B [Cleaved into: Neuromedin-B-32; Neuromedin-B]

1

0

High-throughput

0.279

Low

539670

MBL2
Mannose-binding protein C

1

0

High-throughput

0.279

Low

718401

CD6
T-cell differentiation antigen CD6

1

0

High-throughput

0.279

Low

1134869

MUT7
Exonuclease mut-7 homolog

1

0

High-throughput

0.279

Low

1134870

LPD6B
Ly6/PLAUR domain-containing protein 6B

1

0

High-throughput

0.279

Low

1134873

TMCO6
Transmembrane and coiled-coil domain-containing protein 6

1

0

High-throughput

0.279

Low

869744

MTR1A
Melatonin receptor type 1A

1

0

High-throughput

0.265

Low

411947

NTRK1
High affinity nerve growth factor receptor

1

0

High-throughput

0.249

Low

1134866

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

1134867

SEML
Putative protein SEM1, isoform 2

1

0

High-throughput

0.249

Low

1134862

TMM31
Transmembrane protein 31

1

0

High-throughput

0.232

Low

1134863

ANR22
Ankyrin repeat domain-containing protein 22

1

0

High-throughput

0.232

Low

1134878

S6A16
Orphan sodium- and chloride-dependent neurotransmitter transporter NTT5

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025