Protein: PSA5
Proteasome subunit alpha type-5 (Macropain subunit PUP2) (Multicatalytic endopeptidase complex subunit PUP2) (Proteasome component PUP2) (Proteinase YSCE subunit PUP2)

Gene: PSA5, PUP2
Organism: Saccharomyces cerevisiae S288C
Interactions: 104
UniProt ID: P32379

Gene Ontology (top 5):
GO:0000502 - proteasome complex
GO:0005634 - nucleus
GO:0010499 - proteasomal ubiquitin-independent protein catabolic process
GO:0019773 - proteasome core complex, alpha-subunit complex
GO:0034515 - proteasome storage granule

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

645140

PSB4
Proteasome subunit beta type-4

14

20

Small-scale

0.981

High

636553

PSA7
Probable proteasome subunit alpha type-7

8

20

Small-scale

0.967

High

661477

PSA2
Proteasome subunit alpha type-2

6

19

Small-scale

0.941

High

721237

PSB5
Proteasome subunit beta type-5

6

20

Small-scale

0.935

High

735935

PSA4
Proteasome subunit alpha type-4

6

19

Small-scale

0.935

High

735923

UMP1
Proteasome maturation factor UMP1

4

2

Small-scale

0.881

High

735934

PSA6
Proteasome subunit alpha type-6

4

19

Small-scale

0.881

High

662025

PSB6
Proteasome subunit beta type-6

3

17

High-throughput

0.839

High

735913

PRS6A
26S proteasome regulatory subunit 6A

3

20

High-throughput

0.827

High

735915

PRS7
26S proteasome regulatory subunit 7 homolog

3

20

Small-scale

0.827

High

636640

PSA1
Proteasome subunit alpha type-1

2

19

High-throughput

0.776

High

661385

PSA3
Proteasome subunit alpha type-3

2

20

High-throughput

0.776

High

668371

PSB2
Proteasome subunit beta type-2

2

20

High-throughput

0.776

High

721290

PSB7
Proteasome subunit beta type-7

2

19

High-throughput

0.776

High

735924

PSB1
Proteasome subunit beta type-1

2

20

High-throughput

0.776

High

735968

POC4
Proteasome chaperone 4

1

1

Small-scale

0.770

High

735939

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

12

20

Small-scale

0.755

High

735936

PRS4
26S proteasome regulatory subunit 4 homolog

2

20

High-throughput

0.754

High

735969

RPN5
26S proteasome regulatory subunit RPN5

2

19

Small-scale

0.754

High

735963

POC3
Proteasome chaperone 3

2

1

Small-scale

0.737

High

735938

BLM10
Proteasome activator BLM10

2

6

Small-scale

0.727

High

679037

FUB1
Silencing boundary-establishment protein FUB1

2

1

Small-scale

0.675

High

735927

RPN1
26S proteasome regulatory subunit RPN1

3

20

Small-scale

0.640

High

675232

PSB3
Proteasome subunit beta type-3

1

20

High-throughput

0.618

High

735904

PSA5
Proteasome subunit alpha type-5

1

18

High-throughput

0.618

High

735914

PRS6B
26S proteasome regulatory subunit 6B homolog

1

20

High-throughput

0.618

High

735920

POC2
Proteasome assembly chaperone 2

1

1

High-throughput

0.618

High

735944

PRS10
26S proteasome subunit RPT4

1

20

High-throughput

0.618

High

735953

PRS8
26S proteasome regulatory subunit 8 homolog

1

20

High-throughput

0.618

High

735970

RPN6
26S proteasome regulatory subunit RPN6

1

20

High-throughput

0.618

High

735907

RPN2
26S proteasome regulatory subunit RPN2

2

20

Small-scale

0.595

High

735926

ECM29
Proteasome component ECM29

2

11

High-throughput

0.584

High

735964

RPN8
26S proteasome regulatory subunit RPN8

2

20

Small-scale

0.584

High

735958

POC1
Proteasome chaperone 1

1

1

High-throughput

0.553

High

651909

ESS1
Peptidyl-prolyl cis-trans isomerase ESS1

1

1

High-throughput

0.536

High

660840

PP2A2
Serine/threonine-protein phosphatase PP2A-2 catalytic subunit

1

1

High-throughput

0.515

High

699388

CIN8
Kinesin-like protein CIN8

1

5

High-throughput

0.515

High

449088

CALM
Calmodulin

1

1

Small-scale

0.512

High

735917

NOT4
General negative regulator of transcription subunit 4

1

2

High-throughput

0.501

High

735941

PTK2
Serine/threonine-protein kinase PTK2/STK2

1

6

High-throughput

0.501

High

735945

BRE5
UBP3-associated protein BRE5

1

5

High-throughput

0.489

High

150270

RPN13
26S proteasome regulatory subunit RPN13

1

1

High-throughput

0.479

High

434918

RS3
Small ribosomal subunit protein uS3

1

1

High-throughput

0.479

High

586440

PCNA
Proliferating cell nuclear antigen

1

3

High-throughput

0.479

High

670457

SIS1
Protein SIS1

1

5

High-throughput

0.479

High

701586

UBC8
Ubiquitin-conjugating enzyme E2-24 kDa

1

5

High-throughput

0.479

High

706478

TF2B
Transcription initiation factor IIB

1

1

High-throughput

0.479

High

735905

HOG1
Mitogen-activated protein kinase HOG1

1

3

High-throughput

0.479

High

735906

RPN12
26S proteasome regulatory subunit RPN12

1

3

High-throughput

0.479

High

735910

RAD23
UV excision repair protein RAD23

1

20

High-throughput

0.479

High

735911

GSP1
GTP-binding nuclear protein GSP1/CNR1

1

2

High-throughput

0.479

High

735919

CENPA
Histone H3-like centromeric protein CSE4

1

3

High-throughput

0.479

High

735929

RPN10
26S proteasome regulatory subunit RPN10

1

10

High-throughput

0.479

High

735933

RPN3
26S proteasome regulatory subunit RPN3

1

7

High-throughput

0.479

High

735940

UBP6
Ubiquitin carboxyl-terminal hydrolase 6

1

9

High-throughput

0.479

High

735949

APJ1
J domain-containing protein APJ1

1

6

High-throughput

0.479

High

735951

H3
Histone H3

1

3

High-throughput

0.479

High

735955

TOM1
E3 ubiquitin-protein ligase TOM1

1

9

High-throughput

0.479

High

735956

RUVB1
RuvB-like protein 1

1

2

High-throughput

0.479

High

735957

RPN9
26S proteasome regulatory subunit RPN9

1

11

High-throughput

0.479

High

735959

RPN7
26S proteasome regulatory subunit RPN7

1

20

High-throughput

0.479

High

735971

RUVB2
RuvB-like protein 2

1

2

High-throughput

0.479

High

735972

CMR1
DNA damage-binding protein CMR1

1

2

High-throughput

0.479

High

735931

DHH1
ATP-dependent RNA helicase DHH1

1

2

High-throughput

0.470

High

676613

SGF29
SAGA complex subunit SGF29

1

0

Small-scale

0.458

High

735916

URB1
Nucleolar pre-ribosomal-associated protein 1

1

0

Small-scale

0.458

High

735930

CENPN
Inner kinetochore subunit CHL4

1

0

High-throughput

0.458

High

735937

DSN1
Kinetochore-associated protein DSN1

1

0

High-throughput

0.458

High

735943

INO80
Chromatin-remodeling ATPase INO80

1

0

Small-scale

0.458

High

735946

CWC24
Pre-mRNA-splicing factor CWC24

1

0

High-throughput

0.458

High

735947

CAF40
Protein CAF40

1

0

High-throughput

0.458

High

735960

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

0

High-throughput

0.458

High

735966

YL11B
Transposon Ty1-LR1 Gag-Pol polyprotein

1

0

High-throughput

0.458

High

735908

HSP7F
Heat shock protein homolog SSE1

1

10

High-throughput

0.445

High

735909

HSP79
Heat shock protein homolog SSE2

1

11

High-throughput

0.445

High

441773

RS14A
Small ribosomal subunit protein uS11A

1

1

High-throughput

0.437

High

464573

PBS2
MAP kinase kinase PBS2

1

6

High-throughput

0.437

High

579030

HSC82
ATP-dependent molecular chaperone HSC82

1

2

High-throughput

0.437

High

682203

SPB4
ATP-dependent rRNA helicase SPB4

1

1

High-throughput

0.437

High

735912

RSSA1
Small ribosomal subunit protein uS2A

1

1

High-throughput

0.437

High

735921

NU170
Nucleoporin NUP170

1

1

High-throughput

0.437

High

735922

ATG8
Autophagy-related protein 8

1

6

High-throughput

0.437

High

735932

IF4F1
Eukaryotic initiation factor 4F subunit p150

1

2

High-throughput

0.437

High

735952

RS15
Small ribosomal subunit protein uS19

1

1

High-throughput

0.437

High

735962

VAM6
Vacuolar morphogenesis protein 6

1

2

High-throughput

0.437

High

735965

RS10A
Small ribosomal subunit protein eS10A

1

2

High-throughput

0.437

High

735954

SPP2
Pre-mRNA-splicing factor SPP2

1

0

High-throughput

0.269

Low

735961

ATG13
Autophagy-related protein 13

1

0

High-throughput

0.265

Low

149648

RS9A
Small ribosomal subunit protein uS4A

1

0

High-throughput

0.249

Low

382857

RMAR
Small ribosomal subunit protein uS3m

1

0

High-throughput

0.249

Low

435843

RS13
Small ribosomal subunit protein uS15

1

0

High-throughput

0.249

Low

454934

RS19A
Small ribosomal subunit protein eS19A

1

0

High-throughput

0.249

Low

512319

RS6A
Small ribosomal subunit protein eS6A

1

0

High-throughput

0.249

Low

512883

RS8A
Small ribosomal subunit protein eS8A

1

0

High-throughput

0.249

Low

674481

RS2
Small ribosomal subunit protein uS5

1

0

High-throughput

0.249

Low

689328

RS7A
Small ribosomal subunit protein eS7A

1

0

High-throughput

0.249

Low

735918

RS27A
Small ribosomal subunit protein eS27A

1

0

High-throughput

0.249

Low

735925

RS20
Small ribosomal subunit protein uS10

1

0

High-throughput

0.249

Low

735928

PP2C7
Protein phosphatase 2C homolog 7, mitochondrial

1

0

High-throughput

0.249

Low

735942

RS12
Small ribosomal subunit protein eS12

1

0

High-throughput

0.249

Low

735950

SAM50
Sorting assembly machinery 50 kDa subunit

1

0

High-throughput

0.249

Low

735967

ATG9
Autophagy-related protein 9

1

0

High-throughput

0.249

Low

735948

PFD4
Prefoldin subunit 4

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025