HitPredict

Interactor 1: HSP74 (P34932)
Heat shock 70 kDa protein 4 (HSP70RY) (Heat shock 70-related protein APG-2) (Heat shock protein family H member 2)
Gene: HSPA4

Interactor 2: YAP1 (P46937)
Transcriptional coactivator YAP1 (Yes-associated protein 1) (Protein yorkie homolog) (Yes-associated protein YAP65 homolog)
Gene: YAP1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.71	0.60	0.656

Property	Details
Experiments	24366813, 25796446, 31501420
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 840 Hs			1 504
+	Hs
		125610 HS105_HUMAN (1-840): 0: 938: 62.95		WWP2_HUMAN (12-504): 8.56e-129: 397: 16.54
+	Hs
		320827 HS74L_HUMAN (1-840): 0: 959: 63.21		YAP1_HUMAN (1-504): 7.71e-118: 357: 100.00
+	Hs
		808808 HS105_HUMAN (1-840): 0: 938: 62.95		YAP1_HUMAN (1-504): 7.71e-118: 357: 100.00
+	Hs
		714442 HSP74_HUMAN (1-840): 0: 993: 100.00		WWOX_HUMAN (166-263): 7.4e-29: 120: 30.61
+	Hs
		1267767 HS105_HUMAN (1-840): 0: 938: 62.95		WWOX_HUMAN (166-263): 7.4e-29: 120: 30.61
+	Hs
		1267769 HS105_HUMAN (1-840): 0: 938: 62.95		HECW2_HUMAN (13-303): 1.56e-14: 79: 14.79
+	Sc
		695389 HSP7F_YEAST (5-697): 5.7e-137: 424: 37.61		TOM1_YEAST (261-504): 2.18e-46: 176: 11.34
+	Hs
		125115 HSP7C_HUMAN (564-692): 5.97e-20: 97: 16.92		WWP2_HUMAN (12-504): 8.56e-129: 397: 16.54
+	Hs
		504580 HSP7C_HUMAN (564-692): 5.97e-20: 97: 16.92		ITCH_HUMAN (3-504): 3.59e-121: 378: 15.17
+	Hs
		504792 HSP7C_HUMAN (564-692): 5.97e-20: 97: 16.92		SMUF1_HUMAN (89-504): 7.79e-117: 363: 20.05
+	Hs
		503644 HSP7C_HUMAN (564-692): 5.97e-20: 97: 16.92		YAP1_HUMAN (1-504): 7.71e-118: 357: 100.00
+	Hs
		713923 HS71L_HUMAN (564-691): 7.22e-19: 93.5: 22.48		YAP1_HUMAN (1-504): 7.71e-118: 357: 100.00
+	Hs
		564032 HSP76_HUMAN (587-690): 1.94e-16: 85.8: 22.86		YAP1_HUMAN (1-504): 7.71e-118: 357: 100.00
+	Hs
		564179 HSP76_HUMAN (587-690): 1.94e-16: 85.8: 22.86		WWTR1_HUMAN (51-504): 2.59e-59: 202: 39.83
+	Hs
		504871 HSP7C_HUMAN (564-692): 5.97e-20: 97: 16.92		WWOX_HUMAN (166-263): 7.4e-29: 120: 30.61