HitPredict

Interactor 1: HSP74 (P34932)
Heat shock 70 kDa protein 4 (HSP70RY) (Heat shock 70-related protein APG-2) (Heat shock protein family H member 2)
Gene: HSPA4

Interactor 2: SYVN1 (Q86TM6)
E3 ubiquitin-protein ligase synoviolin (EC 2.3.2.27) (RING-type E3 ubiquitin transferase synoviolin) (Synovial apoptosis inhibitor 1)
Gene: SYVN1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.50	0.489

Property	Details
Experiments	35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 840 Hs			1 617
+	Hs
		714458 HSP74_HUMAN (1-840): 0: 993: 100.00		AMFR_HUMAN (35-572): 1.29e-85: 281: 19.33
+	Hs
		610258 HSP74_HUMAN (1-840): 0: 993: 100.00		CBL_HUMAN (160-604): 1.08e-48: 184: 14.43
+	Hs
		714256 HSP74_HUMAN (1-840): 0: 993: 100.00		RNF43_HUMAN (191-616): 6.1e-29: 124: 12.80
+	Hs
		320885 HS74L_HUMAN (1-840): 0: 959: 63.21		RN149_HUMAN (159-423): 6.7e-35: 138: 17.98
+	Hs
		320871 HS74L_HUMAN (1-840): 0: 959: 63.21		RNF43_HUMAN (191-616): 6.1e-29: 124: 12.80
+	Hs
		1148150 HS105_HUMAN (1-840): 0: 938: 62.95		RNF43_HUMAN (191-616): 6.1e-29: 124: 12.80
+	Sc
		696083 HSP79_YEAST (5-697): 5.63e-139: 429: 38.18		HRD1_YEAST (3-435): 1.57e-59: 210: 21.58
+	Sc
		695656 HSP7F_YEAST (5-697): 5.7e-137: 424: 37.61		HRD1_YEAST (3-435): 1.57e-59: 210: 21.58
+	Hs
		504330 HSP7C_HUMAN (564-692): 5.97e-20: 97: 16.92		SYVN1_HUMAN (1-617): 3.41e-151: 451: 100.00
+	Hs
		714092 HS71L_HUMAN (564-691): 7.22e-19: 93.5: 22.48		AMFR_HUMAN (35-572): 1.29e-85: 281: 19.33
+	Hs
		503442 HSP7C_HUMAN (564-692): 5.97e-20: 97: 16.92		CBL_HUMAN (160-604): 1.08e-48: 184: 14.43
+	Hs
		610257 HS71L_HUMAN (564-691): 7.22e-19: 93.5: 22.48		CBL_HUMAN (160-604): 1.08e-48: 184: 14.43
+	Hs
		564005 HSP76_HUMAN (587-690): 1.94e-16: 85.8: 22.86		CBL_HUMAN (160-604): 1.08e-48: 184: 14.43
+	Mm
		926126 HSP7C_MOUSE (564-692): 1.76e-19: 95.5: 16.15		CBLB_MOUSE (160-462): 1.45e-33: 139: 13.46
+	Hs
		504235 HSP7C_HUMAN (564-692): 5.97e-20: 97: 16.92		RNF43_HUMAN (191-616): 6.1e-29: 124: 12.80
+	Hs
		713994 HS71L_HUMAN (564-691): 7.22e-19: 93.5: 22.48		RNF43_HUMAN (191-616): 6.1e-29: 124: 12.80
+	Hs
		564092 HSP76_HUMAN (587-690): 1.94e-16: 85.8: 22.86		RNF43_HUMAN (191-616): 6.1e-29: 124: 12.80
+	Hs
		714011 HS71L_HUMAN (564-691): 7.22e-19: 93.5: 22.48		GOLI_HUMAN (218-396): 3.58e-27: 116: 19.36