HitPredict

Interactor 1: HSP74 (P34932)
Heat shock 70 kDa protein 4 (HSP70RY) (Heat shock 70-related protein APG-2) (Heat shock protein family H member 2)
Gene: HSPA4

Interactor 2: DNJB4 (Q9UDY4)
DnaJ homolog subfamily B member 4 (Heat shock 40 kDa protein 1 homolog) (HSP40 homolog) (Heat shock protein 40 homolog) (Human liver DnaJ-like protein)
Gene: DNAJB4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	33957083, 35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	DnaJ~HSP70
Common GO terms	GO:0005829 - cytosol GO:0006986 - response to unfolded protein
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 840 Hs			1 337
+	Hs
		279281 HSP74_HUMAN (1-840): 0: 993: 100.00		DNJB5_HUMAN (1-337): 1.41e-131: 380: 60.92
+	Hs
		636257 HSP74_HUMAN (1-840): 0: 993: 100.00		DNJB1_HUMAN (1-335): 7.26e-127: 368: 64.60
+	Hs
		1267773 HS105_HUMAN (1-840): 0: 938: 62.95		DNJB4_HUMAN (1-337): 9.06e-140: 400: 100.00
+	Hs
		1123860 HS105_HUMAN (1-840): 0: 938: 62.95		Q59E89_HUMAN (1-337): 1.44e-137: 395: 99.70
+	Hs
		320814 HS74L_HUMAN (1-840): 0: 959: 63.21		DNJB1_HUMAN (1-335): 7.26e-127: 368: 64.60
+	Hs
		279330 HS105_HUMAN (1-840): 0: 938: 62.95		DNJB5_HUMAN (1-337): 1.41e-131: 380: 60.92
+	Hs
		636386 HS105_HUMAN (1-840): 0: 938: 62.95		DNJB1_HUMAN (1-335): 7.26e-127: 368: 64.60
+	Hs
		681540 HS105_HUMAN (1-840): 0: 938: 62.95		DNJA1_HUMAN (5-335): 9.73e-119: 349: 32.17
+	Dm
		1096122 Q9VUC1_DROME (1-840): 0: 821: 42.10		DNAJ1_DROME (1-335): 6.88e-117: 342: 54.87
+	Ce
		450534 HSP1_CAEEL (2-603): 0: 811: 31.48		Q20774_CAEEL (1-330): 1.64e-115: 339: 52.87
+	Hs
		714326 HSP74_HUMAN (1-840): 0: 993: 100.00		DNJB3_HUMAN (4-108): 5.57e-28: 108: 55.56
+	Sc
		633056 HSP79_YEAST (5-697): 5.63e-139: 429: 38.18		MAS5_YEAST (5-336): 1.57e-111: 331: 30.60
+	Sc
		633055 HSP7F_YEAST (5-697): 5.7e-137: 424: 37.61		MAS5_YEAST (5-336): 1.57e-111: 331: 30.60
+	Sc
		627839 HSP79_YEAST (5-697): 5.63e-139: 429: 38.18		SIS1_YEAST (6-334): 1.26e-53: 181: 33.69
+	Sc
		627838 HSP7F_YEAST (5-697): 5.7e-137: 424: 37.61		SIS1_YEAST (6-334): 1.26e-53: 181: 33.69
+	Hs
		279272 HSP7C_HUMAN (564-692): 5.97e-20: 97: 16.92		DNJB5_HUMAN (1-337): 1.41e-131: 380: 60.92
+	Hs
		503463 HSP7C_HUMAN (564-692): 5.97e-20: 97: 16.92		DNJB1_HUMAN (1-335): 7.26e-127: 368: 64.60
+	Hs
		243275 HSP7C_HUMAN (564-692): 5.97e-20: 97: 16.92		DNJA2_HUMAN (2-336): 8.37e-120: 353: 31.46
+	Hs
		503527 HSP7C_HUMAN (564-692): 5.97e-20: 97: 16.92		DNJA1_HUMAN (5-335): 9.73e-119: 349: 32.17
+	Hs
		504474 HSP7C_HUMAN (564-692): 5.97e-20: 97: 16.92		DNJB3_HUMAN (4-108): 5.57e-28: 108: 55.56