HitPredict

Interactor 1: HSP74 (P34932)
Heat shock 70 kDa protein 4 (HSP70RY) (Heat shock 70-related protein APG-2) (Heat shock protein family H member 2)
Gene: HSPA4

Interactor 2: TRAF6 (Q9Y4K3)
TNF receptor-associated factor 6 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRAF6) (Interleukin-1 signal transducer) (RING finger protein 85) (RING-type E3 ubiquitin transferase TRAF6)
Gene: TRAF6

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.595

Property	Details
Experiments	16697380, 14702098
Identification Methods	affinity chromatography technology, enzymatic study
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 840 Hs			1 522
+	Hs
		320933 HS74L_HUMAN (1-840): 0: 959: 63.21		TRAF6_HUMAN (1-522): 1.12e-151: 445: 100.00
+	Hs
		714201 HSP74_HUMAN (1-840): 0: 993: 100.00		TRAF2_HUMAN (40-500): 7.2e-101: 314: 25.85
+	Mm
		250616 Q3U2G2_MOUSE (1-840): 0: 970: 95.61		LNX1_MOUSE (51-183): 2.1e-11: 68.7: 19.55
+	Mm
		250601 HS74L_MOUSE (1-840): 0: 962: 61.91		LNX1_MOUSE (51-183): 2.1e-11: 68.7: 19.55
+	Hs
		505009 HSP7C_HUMAN (564-692): 5.97e-20: 97: 16.92		TRAF6_HUMAN (1-522): 1.12e-151: 445: 100.00
+	Hs
		714101 HS71L_HUMAN (564-691): 7.22e-19: 93.5: 22.48		TRAF6_HUMAN (1-522): 1.12e-151: 445: 100.00
+	Mm
		926117 HSP7C_MOUSE (564-692): 1.76e-19: 95.5: 16.15		TRAF6_MOUSE (1-522): 5.7e-141: 418: 87.93
+	Mm
		571853 HS71B_MOUSE (571-686): 9.97e-18: 89.7: 23.08		TRAF6_MOUSE (1-522): 5.7e-141: 418: 87.93
+	Hs
		503989 HSP7C_HUMAN (564-692): 5.97e-20: 97: 16.92		TRAF2_HUMAN (40-500): 7.2e-101: 314: 25.85
+	Hs
		713952 HS71L_HUMAN (564-691): 7.22e-19: 93.5: 22.48		TRAF2_HUMAN (40-500): 7.2e-101: 314: 25.85
+	Hs
		503998 HSP7C_HUMAN (564-692): 5.97e-20: 97: 16.92		TRAF1_HUMAN (50-501): 5.58e-64: 216: 19.40
+	Hs
		713954 HS71L_HUMAN (564-691): 7.22e-19: 93.5: 22.48		TRAF1_HUMAN (50-501): 5.58e-64: 216: 19.40
+	Hs
		504072 HSP7C_HUMAN (564-692): 5.97e-20: 97: 16.92		TRI25_HUMAN (63-370): 4.93e-45: 169: 18.61
+	Hs
		713970 HS71L_HUMAN (564-691): 7.22e-19: 93.5: 22.48		TRI25_HUMAN (63-370): 4.93e-45: 169: 18.61
+	Hs
		301573 HSP7C_HUMAN (564-692): 5.97e-20: 97: 16.92		TRI37_HUMAN (56-501): 7.36e-43: 165: 13.89
+	Hs
		563999 HSP76_HUMAN (587-690): 1.94e-16: 85.8: 22.86		RO52_HUMAN (64-403): 5.77e-45: 166: 14.97
+	Hs
		504715 HSP7C_HUMAN (564-692): 5.97e-20: 97: 16.92		TRIM6_HUMAN (56-403): 5.03e-39: 150: 12.97
+	Hs
		503987 HSP7C_HUMAN (564-692): 5.97e-20: 97: 16.92		TRI26_HUMAN (61-410): 2.85e-38: 149: 14.59
+	Hs
		504712 HSP7C_HUMAN (564-692): 5.97e-20: 97: 16.92		TRI31_HUMAN (58-334): 3.02e-35: 138: 15.00
+	Mm
		250598 HS71B_MOUSE (571-686): 9.97e-18: 89.7: 23.08		LNX1_MOUSE (51-183): 2.1e-11: 68.7: 19.55