HitPredict

Interactor 1: B3DN64 (B3DN64)
Guanine nucleotide exchange factor in mesoderm, isoform G (LP15490p)
Gene: GEFmeso

Interactor 2: RAC1 (P40792)
Ras-related protein Rac1
Gene: RAC1

Species: Drosophila melanogaster

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.80	0.686

Property	Details
Experiments	25753922, 15710747
Identification Methods	enzymatic study, two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Ras~RhoGEF
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1237 Dm			1 192
+	Dm
		776895 Q8MSP7_DROME (1-1237): 0: 1113: 99.36		RAC1_DROME (1-192): 3.66e-81: 240: 100.00
+	Dm
		71593 B3DN64_DROME (1-1237): 0: 1118: 100.00		CDC42_DROME (1-192): 4.96e-76: 227: 69.79
+	Hs
		925271 ARHG7_HUMAN (21-744): 4.36e-116: 382: 15.35		RAC1_HUMAN (1-192): 2.19e-83: 246: 91.67
+	Hs
		855782 VAV2_HUMAN (20-747): 8.53e-115: 381: 14.01		RAC1_HUMAN (1-192): 2.19e-83: 246: 91.67
+	Hs
		925289 ARHG6_HUMAN (21-788): 1.21e-114: 378: 15.72		RAC1_HUMAN (1-192): 2.19e-83: 246: 91.67
+	Hs
		925497 ARHG2_HUMAN (104-923): 7.46e-112: 376: 13.67		RAC1_HUMAN (1-192): 2.19e-83: 246: 91.67
+	Hs
		1049733 ARHG7_HUMAN (21-744): 4.36e-116: 382: 15.35		RHOJ_HUMAN (2-190): 4.27e-80: 239: 60.32
+	Hs
		545368 ARHG7_HUMAN (21-744): 4.36e-116: 382: 15.35		RAC2_HUMAN (1-192): 5.01e-80: 238: 89.06
+	Hs
		1066050 ARHG6_HUMAN (21-788): 1.21e-114: 378: 15.72		RHOJ_HUMAN (2-190): 4.27e-80: 239: 60.32
+	Hs
		545388 ARHG6_HUMAN (21-788): 1.21e-114: 378: 15.72		RAC2_HUMAN (1-192): 5.01e-80: 238: 89.06
+	Hs
		892365 ARHG7_HUMAN (21-744): 4.36e-116: 382: 15.35		RAC3_HUMAN (1-191): 1.08e-76: 229: 89.53
+	Hs
		893997 ARHG7_HUMAN (21-744): 4.36e-116: 382: 15.35		CDC42_HUMAN (1-192): 7.64e-77: 229: 69.27
+	Hs
		855778 VAV2_HUMAN (20-747): 8.53e-115: 381: 14.01		CDC42_HUMAN (1-192): 7.64e-77: 229: 69.27
+	Hs
		892381 ARHG6_HUMAN (21-788): 1.21e-114: 378: 15.72		RAC3_HUMAN (1-191): 1.08e-76: 229: 89.53
+	Hs
		894026 ARHG6_HUMAN (21-788): 1.21e-114: 378: 15.72		CDC42_HUMAN (1-192): 7.64e-77: 229: 69.27
+	Hs
		855779 VAV2_HUMAN (20-747): 8.53e-115: 381: 14.01		RHOA_HUMAN (5-192): 1.44e-74: 224: 54.79
+	Hs
		564524 ARHG7_HUMAN (21-744): 4.36e-116: 382: 15.35		RHOQ_HUMAN (4-192): 9.76e-73: 220: 62.05
+	Hs
		900768 ARHG2_HUMAN (104-923): 7.46e-112: 376: 13.67		RHOA_HUMAN (5-192): 1.44e-74: 224: 54.79
+	Hs
		564535 ARHG6_HUMAN (21-788): 1.21e-114: 378: 15.72		RHOQ_HUMAN (4-192): 9.76e-73: 220: 62.05
+	Hs
		564737 PKHG1_HUMAN (167-850): 5.8e-109: 375: 24.97		RHOQ_HUMAN (4-192): 9.76e-73: 220: 62.05