Protein: LSM8
U6 snRNA-associated Sm-like protein LSm8

Gene: LSM8
Organism: Homo sapiens
Interactions: 93
UniProt ID: O95777

Gene Ontology (top 5):
GO:0000398 - mRNA splicing, via spliceosome
GO:0003723 - RNA binding
GO:0003729 - mRNA binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

344583

LSM4
U6 snRNA-associated Sm-like protein LSm4

6

20

Small-scale

0.940

High

344540

SART3
Spliceosome associated factor 3, U4/U6 recycling protein

5

20

High-throughput

0.927

High

344526

LSM3
U6 snRNA-associated Sm-like protein LSm3

4

20

High-throughput

0.904

High

344527

LSM6
U6 snRNA-associated Sm-like protein LSm6

4

20

High-throughput

0.902

High

344579

LSM2
U6 snRNA-associated Sm-like protein LSm2

4

20

Small-scale

0.886

High

344525

RUXF
Small nuclear ribonucleoprotein F

3

20

High-throughput

0.871

High

344531

RSMN
Small nuclear ribonucleoprotein-associated protein N

2

17

High-throughput

0.811

High

344582

LSM5
U6 snRNA-associated Sm-like protein LSm5

2

20

High-throughput

0.811

High

344509

RSMB
Small nuclear ribonucleoprotein-associated proteins B and B'

2

16

High-throughput

0.806

High

344577

LSM7
U6 snRNA-associated Sm-like protein LSm7

2

19

High-throughput

0.806

High

215007

PRPF3
U4/U6 small nuclear ribonucleoprotein Prp3

2

10

High-throughput

0.789

High

344541

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

2

16

High-throughput

0.775

High

209180

PRP4
U4/U6 small nuclear ribonucleoprotein Prp4

4

16

High-throughput

0.699

High

344524

RUXE
Small nuclear ribonucleoprotein E

1

15

High-throughput

0.691

High

344529

SMD3
Small nuclear ribonucleoprotein Sm D3

1

20

High-throughput

0.691

High

344528

SMD1
Small nuclear ribonucleoprotein Sm D1

1

20

High-throughput

0.656

High

344548

PRP8
Pre-mRNA-processing-splicing factor 8

1

10

High-throughput

0.618

High

344581

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

2

5

Small-scale

0.611

High

344535

UBP4
Ubiquitin carboxyl-terminal hydrolase 4

1

5

High-throughput

0.536

High

344546

UBP39
Ubiquitin carboxyl-terminal hydrolase 39

1

5

High-throughput

0.536

High

344537

JIP2
C-Jun-amino-terminal kinase-interacting protein 2

2

3

High-throughput

0.526

High

344576

PHF11
PHD finger protein 11

1

0

High-throughput

0.518

High

240394

PRKN
E3 ubiquitin-protein ligase parkin

1

4

High-throughput

0.515

High

344508

UCHL1
Ubiquitin carboxyl-terminal hydrolase isozyme L1

1

1

High-throughput

0.515

High

344514

SYUA
Alpha-synuclein

1

2

High-throughput

0.515

High

344536

TADBP
TAR DNA-binding protein 43

1

8

High-throughput

0.515

High

289392

U520
U5 small nuclear ribonucleoprotein 200 kDa helicase

1

20

High-throughput

0.508

High

344516

SMBP2
DNA-binding protein SMUBP-2

1

8

High-throughput

0.508

High

344523

RBM5
RNA-binding protein 5

1

2

High-throughput

0.508

High

344532

GTF2I
General transcription factor II-I

1

1

High-throughput

0.508

High

344544

SMU1
WD40 repeat-containing protein SMU1

1

6

High-throughput

0.508

High

344562

RENT1
Regulator of nonsense transcripts 1

1

8

High-throughput

0.508

High

344570

DCP1A
mRNA-decapping enzyme 1A

1

2

High-throughput

0.508

High

344505

SODC
Superoxide dismutase [Cu-Zn]

1

0

High-throughput

0.493

High

344518

HD
Huntingtin

1

0

High-throughput

0.493

High

344513

TALDO
Transaldolase

1

0

High-throughput

0.486

High

344522

6PGD
6-phosphogluconate dehydrogenase, decarboxylating

1

0

High-throughput

0.486

High

344533

RL24
Large ribosomal subunit protein eL24

1

0

High-throughput

0.486

High

344534

EXOSX
Exosome complex component 10

1

0

High-throughput

0.486

High

344543

PDCD2
Programmed cell death protein 2

1

0

High-throughput

0.486

High

344560

MINY1
Ubiquitin carboxyl-terminal hydrolase MINDY-1

1

0

High-throughput

0.486

High

344564

ISOC2
Isochorismatase domain-containing protein 2

1

0

High-throughput

0.486

High

344574

DBF4A
Protein DBF4 homolog A

1

0

High-throughput

0.486

High

344515

HSPA9
Stress-70 protein, mitochondrial

1

4

High-throughput

0.481

High

344547

EXOS6
Exosome complex component MTR3

1

12

High-throughput

0.481

High

344557

MGAP
MAX gene-associated protein

1

1

High-throughput

0.481

High

344558

DCP1B
mRNA-decapping enzyme 1B

1

3

High-throughput

0.481

High

216213

PPIH
Peptidyl-prolyl cis-trans isomerase H

1

6

High-throughput

0.479

High

247583

NUPR1
Nuclear protein 1

1

2

High-throughput

0.479

High

314985

RECQ4
ATP-dependent DNA helicase Q4

1

9

High-throughput

0.479

High

324377

HEXI1
Protein HEXIM1

1

2

High-throughput

0.479

High

344506

MYC
Myc proto-oncogene protein

1

10

High-throughput

0.479

High

344507

MYCN
N-myc proto-oncogene protein

1

9

High-throughput

0.479

High

344520

SOX2
Transcription factor SOX-2

1

3

High-throughput

0.479

High

344539

RBM39
RNA-binding protein 39

1

10

High-throughput

0.479

High

344545

LARP7
La-related protein 7

1

12

High-throughput

0.479

High

344550

MEPCE
7SK snRNA methylphosphate capping enzyme

1

7

High-throughput

0.479

High

344552

THOC4
THO complex subunit 4

1

8

High-throughput

0.479

High

344553

ZCH18
Zinc finger CCCH domain-containing protein 18

1

6

High-throughput

0.479

High

344559

ZGPAT
Zinc finger CCCH-type with G patch domain-containing protein

1

10

Small-scale

0.479

High

344575

ZRAN1
Ubiquitin thioesterase ZRANB1

1

3

High-throughput

0.479

High

344580

TRRAP
Transformation/transcription domain-associated protein

1

2

High-throughput

0.479

High

344538

DCTN1
Dynactin subunit 1

1

1

High-throughput

0.470

High

344567

SEPT5
Septin-5

1

1

High-throughput

0.464

High

344572

ITSN2
Intersectin-2

1

1

High-throughput

0.464

High

344584

KCTD3
BTB/POZ domain-containing protein KCTD3

1

2

High-throughput

0.464

High

344511

ARNT
Aryl hydrocarbon receptor nuclear translocator

1

0

High-throughput

0.460

High

344561

RSCA1
Regulatory solute carrier protein family 1 member 1

1

0

High-throughput

0.460

High

344512

CALX
Calnexin

1

0

High-throughput

0.458

High

344517

CCNF
Cyclin-F

1

0

High-throughput

0.458

High

344521

EMD
Emerin

1

0

Small-scale

0.458

High

344530

RL32
Large ribosomal subunit protein eL32

1

0

High-throughput

0.458

High

344578

RL26L
Ribosomal protein uL24-like

1

0

High-throughput

0.458

High

344563

UB2E3
Ubiquitin-conjugating enzyme E2 E3

1

1

High-throughput

0.457

High

166598

BCKD
Branched-chain alpha-ketoacid dehydrogenase kinase

1

2

High-throughput

0.439

High

344549

MPRIP
Myosin phosphatase Rho-interacting protein

1

1

High-throughput

0.439

High

344566

GMPPA
Mannose-1-phosphate guanylyltransferase regulatory subunit alpha

1

1

High-throughput

0.439

High

344573

SEP10
Septin-10

1

1

High-throughput

0.439

High

156811

CTRO
Citron Rho-interacting kinase

1

3

High-throughput

0.437

High

292989

CD123
Translation initiation factor eIF2 assembly protein

1

1

High-throughput

0.437

High

344542

EEA1
Early endosome antigen 1

1

4

High-throughput

0.437

High

47293

A0A6Q8PF08
Peripheral myelin protein 22

1

0

High-throughput

0.268

Low

344519

MTHR
Methylenetetrahydrofolate reductase

1

0

High-throughput

0.265

Low

344551

URP2
Fermitin family homolog 3

1

0

High-throughput

0.265

Low

344554

CONA1

1

0

High-throughput

0.265

Low

344556

INLR1
Interferon lambda receptor 1

1

0

High-throughput

0.265

Low

344568

THUM3
tRNA

1

0

High-throughput

0.265

Low

143777

NDKM
Nucleoside diphosphate kinase, mitochondrial

1

0

High-throughput

0.251

Low

344555

ECHD2
Enoyl-CoA hydratase domain-containing protein 2, mitochondrial

1

0

High-throughput

0.251

Low

344565

RM48
Large ribosomal subunit protein mL48

1

0

High-throughput

0.251

Low

344569

GPT
UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase

1

0

High-throughput

0.251

Low

344571

OLA1
Obg-like ATPase 1

1

0

High-throughput

0.249

Low

344510

VCAM1
Vascular cell adhesion protein 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025