HitPredict

Interactor 1: CDC27 (P30260)
Cell division cycle protein 27 homolog (Anaphase-promoting complex subunit 3) (APC3) (CDC27 homolog) (CDC27Hs) (H-NUC)
Gene: CDC27

Interactor 2: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	17474147
Identification Methods	peptide array
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005813 - centrosome GO:0005829 - cytosol and 1 others more... GO:0019903 - protein phosphatase binding
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 824 Hs			1 217
+	Hs
		593924 CDC27_HUMAN (1-824): 0: 630: 100.00		NCK1_HUMAN (5-145): 9.5e-23: 96.3: 33.14
+	Hs
		362177 CDC27_HUMAN (1-824): 0: 630: 100.00		ABL1_HUMAN (4-139): 4.41e-22: 95.5: 35.46
+	Hs
		440396 CDC27_HUMAN (1-824): 0: 630: 100.00		FYN_HUMAN (161-215): 9.09e-13: 68.5: 31.58
+	Hs
		292813 CDC27_HUMAN (1-824): 0: 630: 100.00		GRAP2_HUMAN (3-55): 1.97e-10: 61.3: 39.62
+	Hs
		292877 APC7_HUMAN (290-823): 3.42e-61: 219: 16.28		GRAP2_HUMAN (3-55): 1.97e-10: 61.3: 39.62
+	Hs
		440592 TMTC4_HUMAN (603-823): 1.05e-36: 150: 15.84		FYN_HUMAN (161-215): 9.09e-13: 68.5: 31.58
+	Hs
		594075 TTC28_HUMAN (528-814): 2.75e-17: 89.6: 12.13		NCK1_HUMAN (5-145): 9.5e-23: 96.3: 33.14
+	Hs
		185363 OGT1_HUMAN (77-568): 9.79e-24: 109: 8.25		YES_HUMAN (71-215): 7.5e-12: 65.8: 16.33
+	Hs
		292876 CDC23_HUMAN (371-823): 1.04e-24: 111: 12.64		GRAP2_HUMAN (3-55): 1.97e-10: 61.3: 39.62