HitPredict

Interactor 1: MERL (P35240)
Merlin (Moesin-ezrin-radixin-like protein) (Neurofibromin-2) (Schwannomerlin) (Schwannomin)
Gene: NF2

Interactor 2: KSR1 (Q8IVT5)
Kinase suppressor of Ras 1 (EC 2.7.11.1)
Gene: KSR1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	26549023
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	FERM_M~PK_Tyr_Ser-Thr
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0016020 - membrane GO:0032587 - ruffle membrane
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 595 Hs			1 923
+	Hs
		665554 MERL_HUMAN (1-595): 1.12e-172: 504: 100.00		EPHB2_HUMAN (223-895): 5.19e-149: 469: 14.82
+	Hs
		488594 MERL_HUMAN (1-595): 1.12e-172: 504: 100.00		ARAF_HUMAN (261-899): 1.38e-148: 454: 24.55
+	Hs
		665158 MERL_HUMAN (1-595): 1.12e-172: 504: 100.00		EPHA2_HUMAN (223-917): 2.52e-144: 454: 14.62
+	Hs
		373784 MERL_HUMAN (1-595): 1.12e-172: 504: 100.00		RAF1_HUMAN (229-908): 9.62e-143: 440: 22.03
+	Hs
		665555 RADI_HUMAN (19-595): 5.41e-151: 448: 45.47		EPHB2_HUMAN (223-895): 5.19e-149: 469: 14.82
+	Hs
		719689 RADI_HUMAN (19-595): 5.41e-151: 448: 45.47		EPHA5_HUMAN (223-888): 4.57e-149: 469: 14.15
+	Hs
		546943 EZRI_HUMAN (19-595): 8.21e-152: 450: 44.20		EPHA2_HUMAN (223-917): 2.52e-144: 454: 14.62
+	Hs
		640048 MOES_HUMAN (19-595): 5.97e-146: 435: 44.44		EPHB2_HUMAN (223-895): 5.19e-149: 469: 14.82
+	Hs
		373785 RADI_HUMAN (19-595): 5.41e-151: 448: 45.47		RAF1_HUMAN (229-908): 9.62e-143: 440: 22.03
+	Hs
		374912 E41L5_HUMAN (2-595): 6.77e-134: 410: 18.38		RAF1_HUMAN (229-908): 9.62e-143: 440: 22.03
+	Hs
		665337 E41LA_HUMAN (19-416): 3.96e-121: 375: 24.46		EPHA2_HUMAN (223-917): 2.52e-144: 454: 14.62
+	Hs
		375149 FARP1_HUMAN (2-526): 5.38e-114: 366: 18.35		RAF1_HUMAN (229-908): 9.62e-143: 440: 22.03
+	Hs
		375115 E41L3_HUMAN (14-484): 8.79e-113: 363: 21.04		RAF1_HUMAN (229-908): 9.62e-143: 440: 22.03
+	Hs
		204591 E41L2_HUMAN (11-519): 9e-113: 361: 19.70		RAF1_HUMAN (229-908): 9.62e-143: 440: 22.03
+	Hs
		411867 E41L5_HUMAN (2-595): 6.77e-134: 410: 18.38		LCK_HUMAN (591-890): 2.14e-99: 322: 24.59
+	Hs
		411855 E41L1_HUMAN (1-535): 3.42e-120: 378: 21.61		LCK_HUMAN (591-890): 2.14e-99: 322: 24.59
+	Hs
		411904 FARP1_HUMAN (2-526): 5.38e-114: 366: 18.35		LCK_HUMAN (591-890): 2.14e-99: 322: 24.59
+	Hs
		411899 E41L3_HUMAN (14-484): 8.79e-113: 363: 21.04		LCK_HUMAN (591-890): 2.14e-99: 322: 24.59