Protein: CDK12
Cyclin-dependent kinase 12 (EC 2.7.11.22) (EC 2.7.11.23) (Cdc2-related kinase, arginine/serine-rich) (CrkRS) (Cell division cycle 2-related protein kinase 7) (CDC2-related protein kinase 7) (Cell division protein kinase 12) (hCDK12)

Gene: CDK12
Organism: Homo sapiens
Interactions: 181
UniProt ID: Q9NYV4

Gene Ontology (top 5):
GO:0002944 - cyclin K-CDK12 complex
GO:0004672 - protein kinase activity
GO:0004693 - cyclin-dependent protein serine/threonine kinase activity
GO:0005524 - ATP binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

297037

CCNK
Cyclin-K

4

20

Small-scale

0.890

High

898003

CDK9
Cyclin-dependent kinase 9

3

17

High-throughput

0.871

High

1119711

CDK13
Cyclin-dependent kinase 13

3

18

High-throughput

0.861

High

998070

CSK21
Casein kinase II subunit alpha

2

19

High-throughput

0.811

High

1006762

SRPK2
SRSF protein kinase 2

2

19

High-throughput

0.799

High

1099286

SRSF5
Serine/arginine-rich splicing factor 5

2

20

High-throughput

0.776

High

1145407

RNPS1
RNA-binding protein with serine-rich domain 1

2

12

High-throughput

0.776

High

1033272

EWS
RNA-binding protein EWS

2

8

High-throughput

0.757

High

1128129

DHX8
ATP-dependent RNA helicase DHX8

2

5

High-throughput

0.737

High

1157967

DDB1
DNA damage-binding protein 1

1

4

Small-scale

0.692

High

879761

MAPK2
MAP kinase-activated protein kinase 2

1

17

High-throughput

0.691

High

1061186

SRSF1
Serine/arginine-rich splicing factor 1

1

20

High-throughput

0.691

High

1062139

SRSF4
Serine/arginine-rich splicing factor 4

1

20

High-throughput

0.691

High

1099580

SRSF6
Serine/arginine-rich splicing factor 6

1

20

High-throughput

0.691

High

1316638

CDK20
Cyclin-dependent kinase 20

1

17

High-throughput

0.691

High

1412400

ZNF2
Zinc finger protein 2

1

2

High-throughput

0.691

High

1452828

TPX2
Targeting protein for Xklp2

1

3

High-throughput

0.691

High

889513

CLK1
Dual specificity protein kinase CLK1

1

16

High-throughput

0.647

High

868395

CDX1
Homeobox protein CDX-1

2

1

High-throughput

0.628

High

1452826

ANR50
Ankyrin repeat domain-containing protein 50

1

4

High-throughput

0.618

High

243140

PRKN
E3 ubiquitin-protein ligase parkin

1

10

High-throughput

0.618

High

401601

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

20

High-throughput

0.618

High

473140

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

10

High-throughput

0.618

High

753936

CKS2
Cyclin-dependent kinases regulatory subunit 2

1

16

High-throughput

0.618

High

831543

CCNF
Cyclin-F

1

20

High-throughput

0.618

High

956689

CKS1
Cyclin-dependent kinases regulatory subunit 1

1

16

High-throughput

0.618

High

995854

ACTC
Actin, alpha cardiac muscle 1

1

8

High-throughput

0.618

High

1120143

CCNI
Cyclin-I

1

20

High-throughput

0.618

High

1127203

RBM39
RNA-binding protein 39

1

9

Small-scale

0.618

High

1194421

LARP7
La-related protein 7

1

16

High-throughput

0.618

High

1351423

CABL1
CDK5 and ABL1 enzyme substrate 1

1

6

High-throughput

0.618

High

1406791

BARD1
BRCA1-associated RING domain protein 1

1

11

High-throughput

0.618

High

1452821

AFF4
AF4/FMR2 family member 4

1

14

High-throughput

0.618

High

280849

PR40A
Pre-mRNA-processing factor 40 homolog A

2

11

High-throughput

0.605

High

961869

RL37A
Large ribosomal subunit protein eL43

2

0

High-throughput

0.602

High

686487

RL13
Large ribosomal subunit protein eL13

2

4

High-throughput

0.601

High

966949

1433G
14-3-3 protein gamma

2

20

High-throughput

0.601

High

1437374

LN28A
Protein lin-28 homolog A

2

8

High-throughput

0.601

High

558450

XRCC6
X-ray repair cross-complementing protein 6

2

4

High-throughput

0.584

High

995311

CSK2B
Casein kinase II subunit beta

1

1

High-throughput

0.575

High

1209734

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

17

High-throughput

0.575

High

1346960

SNIP1
Smad nuclear-interacting protein 1

1

2

High-throughput

0.575

High

397090

ESR1
Estrogen receptor

2

20

High-throughput

0.571

High

972068

1433E
14-3-3 protein epsilon

2

8

High-throughput

0.571

High

939449

EIF3B
Eukaryotic translation initiation factor 3 subunit B

1

10

High-throughput

0.553

High

1255846

TRI67
Tripartite motif-containing protein 67

1

18

High-throughput

0.553

High

1413734

CABL2
CDK5 and ABL1 enzyme substrate 2

1

6

High-throughput

0.553

High

1434074

PKHA4
Pleckstrin homology domain-containing family A member 4

1

10

High-throughput

0.553

High

1452827

HECD1
E3 ubiquitin-protein ligase HECTD1

1

15

High-throughput

0.553

High

191844

MAGB2
Melanoma-associated antigen B2

1

2

High-throughput

0.536

High

287175

PRKRA
Interferon-inducible double-stranded RNA-dependent protein kinase activator A

1

14

High-throughput

0.536

High

429028

RLA0
Large ribosomal subunit protein uL10

1

5

High-throughput

0.536

High

658443

RS3
Small ribosomal subunit protein uS3

1

4

High-throughput

0.536

High

785497

RL4
Large ribosomal subunit protein uL4

1

4

High-throughput

0.536

High

824401

RL13A
Large ribosomal subunit protein uL13

1

2

High-throughput

0.536

High

855238

NOP2
28S rRNA

1

2

High-throughput

0.536

High

960923

RL15
Large ribosomal subunit protein eL15

1

2

High-throughput

0.536

High

969490

RS8
Small ribosomal subunit protein eS8

1

4

High-throughput

0.536

High

972598

RS14
Small ribosomal subunit protein uS11

1

1

High-throughput

0.536

High

979310

RS6
Small ribosomal subunit protein eS6

1

4

High-throughput

0.536

High

1008916

RED1
Double-stranded RNA-specific editase 1

1

8

High-throughput

0.536

High

1023631

CYC
Cytochrome c

1

2

High-throughput

0.536

High

1111321

SNW1
SNW domain-containing protein 1

1

3

High-throughput

0.536

High

1140039

RRS1
Ribosome biogenesis regulatory protein homolog

1

1

High-throughput

0.536

High

1361784

DGCR8
Microprocessor complex subunit DGCR8

1

1

High-throughput

0.536

High

1368807

EZH1
Histone-lysine N-methyltransferase EZH1

1

6

High-throughput

0.536

High

1413566

H2AJ
Histone H2A.J

1

7

High-throughput

0.536

High

1435376

EGLN3
Prolyl hydroxylase EGLN3

1

6

High-throughput

0.536

High

1452564

BCLF1
Bcl-2-associated transcription factor 1

1

6

High-throughput

0.536

High

1452823

PURG
Purine-rich element-binding protein gamma

1

3

High-throughput

0.536

High

1452825

ZN346
Zinc finger protein 346

1

1

High-throughput

0.536

High

948597

APC15
Anaphase-promoting complex subunit 15

1

0

High-throughput

0.513

High

1452829

ABT1
Activator of basal transcription 1

1

0

High-throughput

0.513

High

1109407

PIN1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

1

1

High-throughput

0.501

High

667485

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

12

Small-scale

0.500

High

1240710

CDC73
Parafibromin

1

2

Small-scale

0.500

High

1330574

PAF1
RNA polymerase II-associated factor 1 homolog

1

2

Small-scale

0.500

High

184929

SPTC1
Serine palmitoyltransferase 1

1

2

High-throughput

0.489

High

860036

RL28
Large ribosomal subunit protein eL28

1

3

High-throughput

0.489

High

935466

FGF8
Fibroblast growth factor 8

1

1

High-throughput

0.489

High

1013347

HTRA4
Serine protease HTRA4

1

5

High-throughput

0.489

High

1127525

FGFP1
Fibroblast growth factor-binding protein 1

1

1

High-throughput

0.489

High

1452833

RL36
Large ribosomal subunit protein eL36

1

3

High-throughput

0.489

High

216025

FIBP
Acidic fibroblast growth factor intracellular-binding protein

1

2

High-throughput

0.479

High

227691

SPOP
Speckle-type POZ protein

1

5

High-throughput

0.479

High

260547

BRD4
Bromodomain-containing protein 4

1

14

High-throughput

0.479

High

325137

HEXI1
Protein HEXIM1

1

11

High-throughput

0.479

High

326073

UBR5
E3 ubiquitin-protein ligase UBR5

1

14

High-throughput

0.479

High

343084

HERC2
E3 ubiquitin-protein ligase HERC2

1

10

High-throughput

0.479

High

373333

MYC
Myc proto-oncogene protein

1

12

High-throughput

0.479

High

406733

MYCN
N-myc proto-oncogene protein

1

13

High-throughput

0.479

High

589882

RFA2
Replication protein A 32 kDa subunit

1

9

High-throughput

0.479

High

596895

MGMT
Methylated-DNA--protein-cysteine methyltransferase

1

2

Small-scale

0.479

High

612802

RL7
Large ribosomal subunit protein uL30

1

5

High-throughput

0.479

High

622857

ERCC3
General transcription and DNA repair factor IIH helicase/translocase subunit XPB

1

8

High-throughput

0.479

High

696700

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

6

High-throughput

0.479

High

769359

RFA3
Replication protein A 14 kDa subunit

1

6

High-throughput

0.479

High

786893

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

16

High-throughput

0.479

High

791778

SYUA
Alpha-synuclein

1

3

High-throughput

0.479

High

862502

YAP1
Transcriptional coactivator YAP1

1

11

High-throughput

0.479

High

872818

SOX2
Transcription factor SOX-2

1

4

Small-scale

0.479

High

905211

MECP2
Methyl-CpG-binding protein 2

1

5

High-throughput

0.479

High

971199

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

8

High-throughput

0.479

High

986771

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

5

High-throughput

0.479

High

996370

EF1A1
Elongation factor 1-alpha 1

1

5

High-throughput

0.479

High

1005176

RNF4
E3 ubiquitin-protein ligase RNF4

1

1

High-throughput

0.479

High

1006178

PI42B
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta

1

6

High-throughput

0.479

High

1024890

VIGLN
Vigilin

1

14

High-throughput

0.479

High

1040764

ENL
Protein ENL

1

15

High-throughput

0.479

High

1045848

TF65
Transcription factor p65

1

7

High-throughput

0.479

High

1048114

TLE3
Transducin-like enhancer protein 3

1

10

High-throughput

0.479

High

1067775

EP300
Histone acetyltransferase p300

1

16

High-throughput

0.479

High

1097596

CBX3
Chromobox protein homolog 3

1

3

High-throughput

0.479

High

1100465

TIF1B
Transcription intermediary factor 1-beta

1

12

High-throughput

0.479

High

1101915

SKP2
S-phase kinase-associated protein 2

1

9

High-throughput

0.479

High

1134554

NOLC1
Nucleolar and coiled-body phosphoprotein 1

1

9

High-throughput

0.479

High

1252783

RN111
E3 ubiquitin-protein ligase Arkadia

1

4

High-throughput

0.479

High

1257151

PAXI1
PAX-interacting protein 1

1

6

High-throughput

0.479

High

1276881

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

8

High-throughput

0.479

High

1289666

NAA40
N-alpha-acetyltransferase 40

1

1

High-throughput

0.479

High

1290777

ZCH18
Zinc finger CCCH domain-containing protein 18

1

7

High-throughput

0.479

High

1313480

SMC5
Structural maintenance of chromosomes protein 5

1

11

High-throughput

0.479

High

1335008

SERB1
SERPINE1 mRNA-binding protein 1

1

7

High-throughput

0.479

High

1339006

NUP43
Nucleoporin Nup43

1

8

High-throughput

0.479

High

1339207

NUP35
Nucleoporin NUP35

1

1

High-throughput

0.479

High

1364631

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

6

High-throughput

0.479

High

1367439

ESR2
Estrogen receptor beta

1

20

High-throughput

0.479

High

1368651

KAT6A
Histone acetyltransferase KAT6A

1

3

High-throughput

0.479

High

1371551

USP9X
Ubiquitin carboxyl-terminal hydrolase 9X

1

4

High-throughput

0.479

High

1387602

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

11

High-throughput

0.479

High

1393770

DDRGK
DDRGK domain-containing protein 1

1

2

High-throughput

0.479

High

1410389

MEP50
Methylosome protein WDR77

1

9

High-throughput

0.479

High

1412828

PCGF1
Polycomb group RING finger protein 1

1

12

High-throughput

0.479

High

1414601

DDX23
Probable ATP-dependent RNA helicase DDX23

1

10

High-throughput

0.479

High

1418408

PCGF6
Polycomb group RING finger protein 6

1

14

High-throughput

0.479

High

1428988

WWTR1
WW domain-containing transcription regulator protein 1

1

9

High-throughput

0.479

High

1450939

NLE1
Notchless protein homolog 1

1

7

High-throughput

0.479

High

1452442

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

2

High-throughput

0.479

High

1452820

ZRAN1
Ubiquitin thioesterase ZRANB1

1

6

High-throughput

0.479

High

1452822

BAZ1B
Tyrosine-protein kinase BAZ1B

1

19

Small-scale

0.479

High

1452830

FZR1
Fizzy-related protein homolog

1

17

High-throughput

0.479

High

1452831

SRRM2
Serine/arginine repetitive matrix protein 2

1

8

High-throughput

0.479

High

1452832

TR150
Thyroid hormone receptor-associated protein 3

1

11

High-throughput

0.479

High

1143287

PLEC
Plectin

1

10

High-throughput

0.470

High

1314063

YAF2
YY1-associated factor 2

1

0

High-throughput

0.458

High

1449230

RAD18
E3 ubiquitin-protein ligase RAD18

1

0

High-throughput

0.458

High

1451247

GPT2L
G patch domain-containing protein 2-like

1

0

High-throughput

0.458

High

1452824

NUP50
Nuclear pore complex protein Nup50

1

0

High-throughput

0.458

High

430439

JUN
Transcription factor Jun

1

10

High-throughput

0.445

High

1034623

AK17A
A-kinase anchor protein 17A

1

3

High-throughput

0.445

High

188049

EIF3H
Eukaryotic translation initiation factor 3 subunit H

1

9

High-throughput

0.437

High

859713

RL21
Large ribosomal subunit protein eL21

1

1

High-throughput

0.437

High

898861

RL14
Large ribosomal subunit protein eL14

1

1

High-throughput

0.437

High

1007549

KRT85
Keratin, type II cuticular Hb5

1

4

High-throughput

0.437

High

1085163

TMM94
Transmembrane protein 94

1

2

High-throughput

0.437

High

1102917

EIF3I
Eukaryotic translation initiation factor 3 subunit I

1

7

High-throughput

0.437

High

1127802

K1H2
Keratin, type I cuticular Ha2

1

5

High-throughput

0.437

High

1133184

LASP1
LIM and SH3 domain protein 1

1

8

Small-scale

0.437

High

1146195

K1H1
Keratin, type I cuticular Ha1

1

5

High-throughput

0.437

High

1215868

RC3H1
Roquin-1

1

2

High-throughput

0.437

High

1227587

A16L1
Autophagy-related protein 16-1

1

12

High-throughput

0.437

High

1295452

C2CD5
C2 domain-containing protein 5

1

5

High-throughput

0.437

High

1438051

RC3H2
Roquin-2

1

11

High-throughput

0.437

High

208404

RRP8
Ribosomal RNA-processing protein 8

1

0

High-throughput

0.426

High

480329

RU1C
U1 small nuclear ribonucleoprotein C

1

0

High-throughput

0.426

High

1292296

S2611
Sodium-independent sulfate anion transporter

1

0

High-throughput

0.426

High

1337425

SRFB1
Serum response factor-binding protein 1

1

0

High-throughput

0.426

High

1330796

S35G3
Solute carrier family 35 member G3

1

2

High-throughput

0.407

High

169216

QCR10
Cytochrome b-c1 complex subunit 10

1

0

High-throughput

0.279

Low

488087

IFI6
Interferon alpha-inducible protein 6

1

0

High-throughput

0.279

Low

515908

SAA1
Serum amyloid A-1 protein

1

0

High-throughput

0.279

Low

1092831

MALL
MAL-like protein

1

0

High-throughput

0.279

Low

1348979

ZCH10
Zinc finger CCHC domain-containing protein 10

1

0

High-throughput

0.279

Low

1384730

I27L1
Interferon alpha-inducible protein 27-like protein 1

1

0

High-throughput

0.279

Low

1388110

ERLEC
Endoplasmic reticulum lectin 1

1

0

High-throughput

0.279

Low

1449801

TM14B
Transmembrane protein 14B

1

0

High-throughput

0.279

Low

1452819

AHSP
Alpha-hemoglobin-stabilizing protein

1

0

High-throughput

0.279

Low

178848

SCAM1
Secretory carrier-associated membrane protein 1

1

0

High-throughput

0.249

Low

1226544

DCA15
DDB1- and CUL4-associated factor 15

1

0

High-throughput

0.249

Low

1244789

HAGHL
Hydroxyacylglutathione hydrolase-like protein

1

0

High-throughput

0.249

Low

1419018

KRA93
Keratin-associated protein 9-3

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025