HitPredict

Interactor 1: CD22 (P35329)
B-cell receptor CD22 (B-lymphocyte cell adhesion molecule) (BL-CAM) (Sialic acid-binding Ig-like lectin 2) (Siglec-2) (T-cell surface antigen Leu-14) (CD antigen CD22)
Gene: CD22

Interactor 2: GRB2 (Q60631)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2)
Gene: GRB2

Species: Mus musculus

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.67	0.60	0.634

Property	Details
Experiments	10373493, 11551923
Identification Methods	unspecified method, far western blotting, affinity chromatography technology, coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0019903 - protein phosphatase binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 868 Mm			1 217
+	Hs
		590607 CD22_HUMAN (19-868): 1.88e-168: 512: 58.73		GRB2_HUMAN (1-217): 6.92e-74: 224: 99.54
+	Hs
		433569 CD22_HUMAN (19-868): 1.88e-168: 512: 58.73		LYN_HUMAN (136-215): 4.12e-10: 60.7: 24.39
+	Hs
		924478 PGBM_HUMAN (12-447): 2.91e-52: 201: 18.05		GRB2_HUMAN (1-217): 6.92e-74: 224: 99.54
+	Hs
		297885 NFASC_HUMAN (10-707): 1.08e-36: 151: 11.49		GRB2_HUMAN (1-217): 6.92e-74: 224: 99.54
+	Hs
		433742 PTK7_HUMAN (19-795): 5.66e-90: 309: 15.11		LYN_HUMAN (136-215): 4.12e-10: 60.7: 24.39
+	Hs
		581649 VCAM1_HUMAN (443-789): 1.66e-29: 127: 19.27		GRB2_HUMAN (1-217): 6.92e-74: 224: 99.54
+	Hs
		235234 NPHN_HUMAN (23-826): 1.66e-64: 237: 17.40		NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14
+	Hs
		235231 NPHN_HUMAN (23-826): 1.66e-64: 237: 17.40		FYN_HUMAN (161-215): 4.88e-13: 69.2: 31.58
+	Hs
		235232 NPHN_HUMAN (23-826): 1.66e-64: 237: 17.40		YES_HUMAN (75-215): 5.41e-12: 66.1: 18.37
+	Hs
		297883 NFASC_HUMAN (10-707): 1.08e-36: 151: 11.49		NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14
+	Hs
		297880 NFASC_HUMAN (10-707): 1.08e-36: 151: 11.49		ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46
+	Hs
		434111 ROBO1_HUMAN (63-777): 8.4e-45: 177: 12.72		LYN_HUMAN (136-215): 4.12e-10: 60.7: 24.39
+	Hs
		297881 NFASC_HUMAN (10-707): 1.08e-36: 151: 11.49		FYN_HUMAN (161-215): 4.88e-13: 69.2: 31.58
+	Hs
		581877 VCAM1_HUMAN (443-789): 1.66e-29: 127: 19.27		ITSN2_HUMAN (2-61): 3.57e-15: 75.7: 36.67
+	Hs
		412004 MAG_HUMAN (261-688): 6.38e-31: 131: 19.08		FYN_HUMAN (161-215): 4.88e-13: 69.2: 31.58
+	Hs
		433249 VCAM1_HUMAN (443-789): 1.66e-29: 127: 19.27		YES_HUMAN (75-215): 5.41e-12: 66.1: 18.37
+	Hs
		234472 DSCAM_HUMAN (304-637): 1.67e-15: 83.6: 15.47		NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14
+	Hs
		433804 SDK2_HUMAN (129-862): 6.63e-20: 97.8: 9.39		LYN_HUMAN (136-215): 4.12e-10: 60.7: 24.39
+	Hs
		434019 ROBO2_HUMAN (22-393): 6.98e-20: 97.7: 14.71		LYN_HUMAN (136-215): 4.12e-10: 60.7: 24.39
+	Hs
		855816 TITIN_HUMAN (42-165): 8.26e-10: 65.1: 13.74		VAV2_HUMAN (3-56): 6.02e-11: 63.1: 38.18