Protein: RPA12
DNA-directed RNA polymerase I subunit RPA12 (A12) (A12.2) (DNA-directed RNA polymerase I 13.7 kDa polypeptide)

Gene: RPA12
Organism: Saccharomyces cerevisiae S288C
Interactions: 78
UniProt ID: P32529

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0003676 - nucleic acid binding
GO:0003899 - DNA-directed RNA polymerase activity
GO:0005634 - nucleus
GO:0005736 - RNA polymerase I complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

644891

RPA2
DNA-directed RNA polymerase I subunit RPA135

9

13

Small-scale

0.972

High

534235

RPA1
DNA-directed RNA polymerase I subunit RPA190

8

20

Small-scale

0.963

High

632143

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

4

7

High-throughput

0.896

High

739548

RPA49
DNA-directed RNA polymerase I subunit RPA49

3

3

Small-scale

0.830

High

739536

RPA43
DNA-directed RNA polymerase I subunit RPA43

5

1

Small-scale

0.714

High

459055

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

4

13

High-throughput

0.694

High

632240

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

4

7

High-throughput

0.694

High

645036

RPAB5
DNA-directed RNA polymerases I, II, and III subunit RPABC5

4

6

High-throughput

0.694

High

739547

CDC14
Tyrosine-protein phosphatase CDC14

4

1

High-throughput

0.691

High

632322

RPAB3
DNA-directed RNA polymerases I, II, and III subunit RPABC3

3

5

High-throughput

0.662

High

699987

RPAC2
DNA-directed RNA polymerases I and III subunit RPAC2

3

9

High-throughput

0.662

High

739542

RPA14
DNA-directed RNA polymerase I subunit RPA14

4

0

Small-scale

0.650

High

739537

RPA34
DNA-directed RNA polymerase I subunit RPA34

3

0

Small-scale

0.616

High

739533

DSN1
Kinetochore-associated protein DSN1

2

2

High-throughput

0.584

High

739523

MSN4
Zinc finger protein MSN4

1

1

Small-scale

0.573

High

544196

SSB1
Ribosome-associated molecular chaperone SSB1

2

5

High-throughput

0.552

High

739530

SSB2
Ribosome-associated molecular chaperone SSB2

2

5

High-throughput

0.552

High

739550

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

1

High-throughput

0.536

High

739526

ANM1
Protein arginine N-methyltransferase 1

1

0

Small-scale

0.518

High

656721

KC12
Casein kinase I homolog 2

1

1

High-throughput

0.501

High

739545

BRE5
UBP3-associated protein BRE5

1

2

High-throughput

0.489

High

444753

SIR2
NAD-dependent histone deacetylase SIR2

1

1

High-throughput

0.479

High

706530

TF2B
Transcription initiation factor IIB

1

6

High-throughput

0.479

High

739525

GBLP
Small ribosomal subunit protein RACK1

1

1

High-throughput

0.479

High

739531

RPAB4
DNA-directed RNA polymerases I, II, and III subunit RPABC4

1

5

High-throughput

0.479

High

739546

APJ1
J domain-containing protein APJ1

1

4

High-throughput

0.479

High

739554

TOM1
E3 ubiquitin-protein ligase TOM1

1

3

High-throughput

0.479

High

739558

IWR1
RNA polymerase II nuclear localization protein IWR1

1

1

High-throughput

0.479

High

739532

ULP2
Ubiquitin-like-specific protease 2

1

0

High-throughput

0.460

High

739553

RNT1
Ribonuclease 3

1

0

Small-scale

0.460

High

434934

RS3
Small ribosomal subunit protein uS3

1

0

High-throughput

0.458

High

448294

PDE2
3',5'-cyclic-nucleotide phosphodiesterase 2

1

0

High-throughput

0.458

High

689339

RS7A
Small ribosomal subunit protein eS7A

1

0

High-throughput

0.458

High

739524

RS27A
Small ribosomal subunit protein eS27A

1

0

High-throughput

0.458

High

739527

RRN10
RNA polymerase I-specific transcription initiation factor RRN10

1

0

High-throughput

0.458

High

739539

MOG1
Nuclear import protein MOG1

1

0

High-throughput

0.458

High

739544

RRN9
RNA polymerase I-specific transcription initiation factor RRN9

1

0

High-throughput

0.458

High

739555

VMS1
tRNA endonuclease VMS1

1

0

High-throughput

0.458

High

739560

MAK21
Ribosome biogenesis protein MAK21

1

0

High-throughput

0.458

High

523381

HSP71
Heat shock protein SSA1

1

4

High-throughput

0.445

High

526198

HSP72
Heat shock protein SSA2

1

5

High-throughput

0.445

High

441787

RS14A
Small ribosomal subunit protein uS11A

1

1

High-throughput

0.437

High

579056

HSC82
ATP-dependent molecular chaperone HSC82

1

2

High-throughput

0.437

High

739535

BUD27
Bud site selection protein 27

1

1

High-throughput

0.437

High

739538

NET1
Nucleolar protein NET1

1

1

High-throughput

0.437

High

739543

EIF2A
Eukaryotic translation initiation factor 2A

1

1

High-throughput

0.437

High

739552

TOF2
Topoisomerase 1-associated factor 2

1

1

High-throughput

0.437

High

403414

PABP
Polyadenylate-binding protein, cytoplasmic and nuclear

1

0

High-throughput

0.426

High

684659

RL5
Large ribosomal subunit protein uL18

1

0

High-throughput

0.426

High

739319

ZUO1
Zuotin

1

1

High-throughput

0.407

High

739521

RSSA1
Small ribosomal subunit protein uS2A

2

0

High-throughput

0.298

High

739528

RCK2
Serine/threonine-protein kinase RCK2

1

0

High-throughput

0.261

Low

739549

BCK1
Serine/threonine-protein kinase BCK1/SLK1/SSP31

1

0

High-throughput

0.261

Low

149656

RS9A
Small ribosomal subunit protein uS4A

1

0

High-throughput

0.249

Low

383587

RS17A
Small ribosomal subunit protein eS17A

1

0

High-throughput

0.249

Low

410006

RL25
Large ribosomal subunit protein uL23

1

0

High-throughput

0.249

Low

433522

RL26A
Large ribosomal subunit protein uL24A

1

0

High-throughput

0.249

Low

435852

RS13
Small ribosomal subunit protein uS15

1

0

High-throughput

0.249

Low

454943

RS19A
Small ribosomal subunit protein eS19A

1

0

High-throughput

0.249

Low

502923

RS22A
Small ribosomal subunit protein uS8A

1

0

High-throughput

0.249

Low

504108

RL31A
Large ribosomal subunit protein eL31A

1

0

High-throughput

0.249

Low

512328

RS6A
Small ribosomal subunit protein eS6A

1

0

High-throughput

0.249

Low

512892

RS8A
Small ribosomal subunit protein eS8A

1

0

High-throughput

0.249

Low

514526

RS18A
Small ribosomal subunit protein uS13A

1

0

High-throughput

0.249

Low

674492

RS2
Small ribosomal subunit protein uS5

1

0

High-throughput

0.249

Low

677322

KRR1
KRR1 small subunit processome component

1

0

High-throughput

0.249

Low

739522

RS3A1
Small ribosomal subunit protein eS1A

1

0

High-throughput

0.249

Low

739529

RS20
Small ribosomal subunit protein uS10

1

0

High-throughput

0.249

Low

739534

UTP10
U3 small nucleolar RNA-associated protein 10

1

0

High-throughput

0.249

Low

739540

RS12
Small ribosomal subunit protein eS12

1

0

High-throughput

0.249

Low

739551

RS15
Small ribosomal subunit protein uS19

1

0

High-throughput

0.249

Low

739556

RRP5
rRNA biogenesis protein RRP5

1

0

High-throughput

0.249

Low

739557

VAM6
Vacuolar morphogenesis protein 6

1

0

Small-scale

0.249

Low

739559

RS10A
Small ribosomal subunit protein eS10A

1

0

High-throughput

0.249

Low

427185

RLA0
Large ribosomal subunit protein uL10

1

0

High-throughput

0.232

Low

569736

RL30
Large ribosomal subunit protein eL30

1

0

High-throughput

0.232

Low

712525

RL8B
Large ribosomal subunit protein eL8B

1

0

High-throughput

0.232

Low

739541

IMDH3
Inosine-5'-monophosphate dehydrogenase 3

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025