Protein: RPB9
DNA-directed RNA polymerase II subunit RPB9 (RNA polymerase II subunit B9) (DNA-directed RNA polymerase II subunit I) (RNA polymerase II 14.5 kDa subunit) (RPB14.5)

Gene: RPB9, POLR2I
Organism: Homo sapiens
Interactions: 125
UniProt ID: P36954

Gene Ontology (top 5):
GO:0001193 - maintenance of transcriptional fidelity during transcription elongation by RNA polymerase II
GO:0003676 - nucleic acid binding
GO:0003899 - DNA-directed RNA polymerase activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

667197

RPB1
DNA-directed RNA polymerase II subunit RPB1

4

20

Small-scale

0.890

High

621828

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

3

7

High-throughput

0.871

High

722901

RPB2
DNA-directed RNA polymerase II subunit RPB2

2

12

High-throughput

0.789

High

787741

RPB7
DNA-directed RNA polymerase II subunit RPB7

7

9

High-throughput

0.747

High

787801

PIHD1
PIH1 domain-containing protein 1

5

3

High-throughput

0.714

High

787738

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

4

6

High-throughput

0.699

High

787794

RPR1B
Regulation of nuclear pre-mRNA domain-containing protein 1B

4

8

High-throughput

0.699

High

192792

RPB4
DNA-directed RNA polymerase II subunit RPB4

3

4

High-throughput

0.675

High

335963

MED26
Mediator of RNA polymerase II transcription subunit 26

3

1

High-throughput

0.667

High

787734

RPB11
DNA-directed RNA polymerase II subunit RPB11-a

3

8

High-throughput

0.667

High

316260

RECQ5
ATP-dependent DNA helicase Q5

3

3

Small-scale

0.656

High

262486

MCE1
mRNA-capping enzyme

3

2

High-throughput

0.650

High

48917

MED19
Mediator of RNA polymerase II transcription subunit 19

3

0

High-throughput

0.638

High

130391

SPT5H
Transcription elongation factor SPT5

2

3

High-throughput

0.628

High

787759

RPAP2
Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2

2

2

High-throughput

0.628

High

165018

RPC1
DNA-directed RNA polymerase III subunit RPC1

1

20

High-throughput

0.618

High

339949

RPA1
DNA-directed RNA polymerase I subunit RPA1

1

20

High-throughput

0.618

High

787782

RPA49
DNA-directed RNA polymerase I subunit RPA49

1

3

High-throughput

0.618

High

787791

RPA2
DNA-directed RNA polymerase I subunit RPA2

1

12

High-throughput

0.618

High

787798

RPC5
DNA-directed RNA polymerase III subunit RPC5

1

3

High-throughput

0.618

High

787799

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

12

High-throughput

0.618

High

787753

GL1AD
DNA-directed RNA polymerase II subunit GRINL1A, isoforms 4/5

4

2

High-throughput

0.617

High

131773

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

2

1

High-throughput

0.611

High

621572

RPB3
DNA-directed RNA polymerase II subunit RPB3

2

12

High-throughput

0.611

High

787733

RPAB3
DNA-directed RNA polymerases I, II, and III subunit RPABC3

2

5

High-throughput

0.611

High

787735

RPAB4
DNA-directed RNA polymerases I, II, and III subunit RPABC4

2

5

High-throughput

0.611

High

787744

RPAB5
DNA-directed RNA polymerases I, II, and III subunit RPABC5

2

5

High-throughput

0.611

High

787808

UXT
Protein UXT

2

2

High-throughput

0.611

High

787813

GPN3
GPN-loop GTPase 3

3

5

High-throughput

0.609

High

681764

RBTN2
Rhombotin-2

2

0

High-throughput

0.602

High

505999

GRL1A
DNA-directed RNA polymerase II subunit GRINL1A

3

0

High-throughput

0.585

High

787746

MED21
Mediator of RNA polymerase II transcription subunit 21

2

0

High-throughput

0.585

High

787778

MED10
Mediator of RNA polymerase II transcription subunit 10

2

0

High-throughput

0.585

High

395611

ESR1
Estrogen receptor

2

1

High-throughput

0.571

High

477938

SNRPA
U1 small nuclear ribonucleoprotein A

1

1

High-throughput

0.536

High

634330

LMNB1
Lamin-B1

1

4

High-throughput

0.536

High

787745

TF2B
Transcription initiation factor IIB

1

6

High-throughput

0.536

High

787750

INT11
Integrator complex subunit 11

1

1

High-throughput

0.536

High

787758

RBM45
RNA-binding protein 45

1

1

High-throughput

0.536

High

787763

WDR48
WD repeat-containing protein 48

1

1

High-throughput

0.536

High

787766

CUL5
Cullin-5

1

1

High-throughput

0.536

High

787775

RPR1A
Regulation of nuclear pre-mRNA domain-containing protein 1A

1

8

High-throughput

0.536

High

787783

WWP1
NEDD4-like E3 ubiquitin-protein ligase WWP1

1

3

High-throughput

0.536

High

787785

NELFA
Negative elongation factor A

1

1

High-throughput

0.536

High

787796

INT9
Integrator complex subunit 9

1

1

High-throughput

0.536

High

787817

CTDP1
RNA polymerase II subunit A C-terminal domain phosphatase

1

2

High-throughput

0.536

High

280529

PR40A
Pre-mRNA-processing factor 40 homolog A

1

3

High-throughput

0.515

High

787743

RAN
GTP-binding nuclear protein Ran

1

1

High-throughput

0.515

High

219475

MED7
Mediator of RNA polymerase II transcription subunit 7

1

0

High-throughput

0.513

High

787740

RUXF
Small nuclear ribonucleoprotein F

1

0

High-throughput

0.513

High

787752

INT3
Integrator complex subunit 3

1

0

High-throughput

0.513

High

787757

INT8
Integrator complex subunit 8

1

0

High-throughput

0.513

High

787761

MS3L1
MSL complex subunit 3

1

0

High-throughput

0.513

High

787764

NELFB
Negative elongation factor B

1

0

High-throughput

0.513

High

787768

INT12
Integrator complex subunit 12

1

0

High-throughput

0.513

High

787769

CPNE2
Copine-2

1

0

High-throughput

0.513

High

787771

DCNL1
DCN1-like protein 1

1

0

High-throughput

0.513

High

787772

MED30
Mediator of RNA polymerase II transcription subunit 30

1

0

High-throughput

0.513

High

787777

EPAS1
Endothelial PAS domain-containing protein 1

1

0

High-throughput

0.513

High

787780

MED18
Mediator of RNA polymerase II transcription subunit 18

1

0

High-throughput

0.513

High

787787

CAPAM
mRNA

1

0

High-throughput

0.513

High

787803

MED29
Mediator of RNA polymerase II transcription subunit 29

1

0

High-throughput

0.513

High

787804

CARF
CDKN2A-interacting protein

1

0

High-throughput

0.513

High

787815

MED31
Mediator of RNA polymerase II transcription subunit 31

1

0

High-throughput

0.513

High

787737

CASP6
Caspase-6

1

0

High-throughput

0.493

High

787776

TCPQM
T-complex protein 1 subunit theta-like 2

1

1

High-throughput

0.489

High

172521

XPO1
Exportin-1

1

3

High-throughput

0.479

High

180245

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

1

12

High-throughput

0.479

High

190837

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

2

High-throughput

0.479

High

239544

MED14
Mediator of RNA polymerase II transcription subunit 14

1

6

High-throughput

0.479

High

259546

BRD4
Bromodomain-containing protein 4

1

3

High-throughput

0.479

High

287442

RPC9
DNA-directed RNA polymerase III subunit RPC9

1

3

High-throughput

0.479

High

287767

MED6
Mediator of RNA polymerase II transcription subunit 6

1

2

High-throughput

0.479

High

316363

RMP
Unconventional prefoldin RPB5 interactor 1

1

2

High-throughput

0.479

High

371342

MYC
Myc proto-oncogene protein

1

1

High-throughput

0.479

High

405853

MYCN
N-myc proto-oncogene protein

1

1

High-throughput

0.479

High

430614

RPC4
DNA-directed RNA polymerase III subunit RPC4

1

3

High-throughput

0.479

High

666804

CCNC
Cyclin-C

1

3

High-throughput

0.479

High

787730

BRCA1
Breast cancer type 1 susceptibility protein

1

2

High-throughput

0.479

High

787732

CDK8
Cyclin-dependent kinase 8

1

5

High-throughput

0.479

High

787736

TERA
Transitional endoplasmic reticulum ATPase

1

3

High-throughput

0.479

High

787742

H4
Histone H4

1

1

High-throughput

0.479

High

787747

CUL3
Cullin-3

1

1

High-throughput

0.479

High

787751

RPRD2
Regulation of nuclear pre-mRNA domain-containing protein 2

1

7

High-throughput

0.479

High

787756

MD13L
Mediator of RNA polymerase II transcription subunit 13-like

1

1

High-throughput

0.479

High

787760

SMC5
Structural maintenance of chromosomes protein 5

1

3

High-throughput

0.479

High

787762

SIR6
NAD-dependent protein deacylase sirtuin-6

1

1

High-throughput

0.479

High

787767

MED12
Mediator of RNA polymerase II transcription subunit 12

1

1

High-throughput

0.479

High

787781

CDK19
Cyclin-dependent kinase 19

1

5

High-throughput

0.479

High

787789

SFR19
Splicing factor, arginine/serine-rich 19

1

1

High-throughput

0.479

High

787790

MED20
Mediator of RNA polymerase II transcription subunit 20

1

1

High-throughput

0.479

High

787792

GPN1
GPN-loop GTPase 1

1

5

High-throughput

0.479

High

787793

MED4
Mediator of RNA polymerase II transcription subunit 4

1

2

High-throughput

0.479

High

787797

MED17
Mediator of RNA polymerase II transcription subunit 17

1

1

High-throughput

0.479

High

787806

RPA12
DNA-directed RNA polymerase I subunit RPA12

1

6

High-throughput

0.479

High

787807

PHRF1
PHD and RING finger domain-containing protein 1

1

1

High-throughput

0.479

High

787810

ZRAN1
Ubiquitin thioesterase ZRANB1

1

5

High-throughput

0.479

High

787811

MED13
Mediator of RNA polymerase II transcription subunit 13

1

1

High-throughput

0.479

High

787812

PFD2
Prefoldin subunit 2

1

3

High-throughput

0.479

High

787814

RPC10
DNA-directed RNA polymerase III subunit RPC10

1

6

High-throughput

0.479

High

787816

RPC8
DNA-directed RNA polymerase III subunit RPC8

1

9

High-throughput

0.479

High

326308

SCAF4
SR-related and CTD-associated factor 4

1

0

High-throughput

0.458

High

787731

VHL
von Hippel-Lindau disease tumor suppressor

1

0

High-throughput

0.458

High

787739

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.458

High

787748

MED22
Mediator of RNA polymerase II transcription subunit 22

1

0

High-throughput

0.458

High

787749

MED1
Mediator of RNA polymerase II transcription subunit 1

1

0

High-throughput

0.458

High

787754

MED27
Mediator of RNA polymerase II transcription subunit 27

1

0

High-throughput

0.458

High

787770

MED8
Mediator of RNA polymerase II transcription subunit 8

1

0

High-throughput

0.458

High

787784

MED28
Mediator of RNA polymerase II transcription subunit 28

1

0

High-throughput

0.458

High

787800

MED9
Mediator of RNA polymerase II transcription subunit 9

1

0

High-throughput

0.458

High

787805

MED11
Mediator of RNA polymerase II transcription subunit 11

1

0

High-throughput

0.458

High

505945

MYZAP
Myocardial zonula adherens protein

1

1

High-throughput

0.445

High

787774

DAA10
Dynein axonemal assembly factor 10

1

2

High-throughput

0.437

High

787786

PKHA4
Pleckstrin homology domain-containing family A member 4

1

2

High-throughput

0.437

High

787788

RPAP3
RNA polymerase II-associated protein 3

1

3

High-throughput

0.437

High

787795

PDRG1
p53 and DNA damage-regulated protein 1

1

2

High-throughput

0.437

High

787755

SYDE1
Rho GTPase-activating protein SYDE1

2

0

High-throughput

0.328

High

787779

TBCD
Tubulin-specific chaperone D

1

0

High-throughput

0.282

High

787765

F168A
Protein FAM168A

1

0

High-throughput

0.279

Low

787802

ASB6
Ankyrin repeat and SOCS box protein 6

1

0

High-throughput

0.279

Low

787809

FBLN5
Fibulin-5

1

0

High-throughput

0.279

Low

561928

LAMP2
Lysosome-associated membrane glycoprotein 2

1

0

High-throughput

0.268

Low

719866

HMOX2
Heme oxygenase 2

1

0

High-throughput

0.268

Low

341199

VATG2
V-type proton ATPase subunit G 2

1

0

High-throughput

0.249

Low

787773

NEUL4
Neuralized-like protein 4

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025