HitPredict - High confidence protein-protein interactions

Interactor 1: NMDE1 (P35436)
Glutamate receptor ionotropic, NMDA 2A (GluN2A) (Glutamate [NMDA] receptor subunit epsilon-1) (N-methyl D-aspartate receptor subtype 2A) (NMDAR2A) (NR2A)
Gene: Grin2a

Interactor 2: NMDZ1 (P35438)
Glutamate receptor ionotropic, NMDA 1 (GluN1) (Glutamate [NMDA] receptor subunit zeta-1) (N-methyl-D-aspartate receptor subunit NR1) (NMD-R1)
Gene: Grin1

Species: Mus musculus

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.93	1.00	0.965

Property	Details
Experiments	30284099, 10862698, 9003035, 16554481, 14645471, 15663482, 17018287, 19243221, 34646371
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation, coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	ANF_receptor~ANF_receptor, ANF_receptor~Lig_chan, ANF_receptor~Lig_chan-Glu_bd, Lig_chan~Lig_chan, Lig_chan~Lig_chan-Glu_bd, Lig_chan~SBP_bac_3, Lig_chan-Glu_bd~Lig_chan-Glu_bd, Lig_chan-Glu_bd~SBP_bac_3, SBP_bac_3~SBP_bac_3
Common GO terms	GO:0001964 - startle response GO:0001975 - response to amphetamine GO:0004970 - glutamate-gated receptor activity GO:0004972 - NMDA glutamate receptor activity GO:0005102 - signaling receptor binding and 48 others more... GO:0005261 - monoatomic cation channel activity GO:0005262 - calcium channel activity GO:0005737 - cytoplasm GO:0005783 - endoplasmic reticulum GO:0005886 - plasma membrane GO:0006816 - calcium ion transport GO:0007268 - chemical synaptic transmission GO:0007611 - learning or memory GO:0007612 - learning GO:0007613 - memory GO:0008021 - synaptic vesicle GO:0008542 - visual learning GO:0009986 - cell surface GO:0014069 - postsynaptic density GO:0016020 - membrane GO:0016595 - glutamate binding GO:0017146 - NMDA selective glutamate receptor complex GO:0019233 - sensory perception of pain GO:0022843 - voltage-gated monoatomic cation channel activity GO:0032590 - dendrite membrane GO:0035235 - ionotropic glutamate receptor signaling pathway GO:0035249 - synaptic transmission, glutamatergic GO:0035254 - glutamate receptor binding GO:0042391 - regulation of membrane potential GO:0042734 - presynaptic membrane GO:0043005 - neuron projection GO:0043065 - positive regulation of apoptotic process GO:0043195 - terminal bouton GO:0043197 - dendritic spine GO:0044877 - protein-containing complex binding GO:0045202 - synapse GO:0045211 - postsynaptic membrane GO:0048167 - regulation of synaptic plasticity GO:0048168 - regulation of neuronal synaptic plasticity GO:0048169 - regulation of long-term neuronal synaptic plasticity GO:0048511 - rhythmic process GO:0051968 - positive regulation of synaptic transmission, glutamatergic GO:0060079 - excitatory postsynaptic potential GO:0097060 - synaptic membrane GO:0098655 - monoatomic cation transmembrane transport GO:0098688 - parallel fiber to Purkinje cell synapse GO:0098839 - postsynaptic density membrane GO:0098978 - glutamatergic synapse GO:0099507 - ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential GO:1903539 - protein localization to postsynaptic membrane GO:1904062 - regulation of monoatomic cation transmembrane transport GO:1904315 - transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential GO:2000463 - positive regulation of excitatory postsynaptic potential
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1	1464
Mm

1	938

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024