HitPredict

Interactor 1: MSX2 (P35548)
Homeobox protein MSX-2 (Homeobox protein Hox-8)
Gene: MSX2

Interactor 2: ZN703 (Q9H7S9)
Zinc finger protein 703 (Zinc finger elbow-related proline domain protein 1)
Gene: ZNF703

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.667

Property	Details
Experiments	26186194, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0045892 - negative regulation of DNA-templated transcription GO:0071392 - cellular response to estradiol stimulus
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 267 Hs			1 590
+	Hs
		679172 TLX1_HUMAN (76-216): 1.68e-37: 136: 31.47		ZN703_HUMAN (1-590): 4.35e-103: 325: 100.00
+	Hs
		830026 HXA1_HUMAN (8-214): 5.44e-31: 119: 24.66		ZN703_HUMAN (1-590): 4.35e-103: 325: 100.00
+	Hs
		620206 PAX7_HUMAN (8-260): 3.22e-29: 116: 15.71		ZN703_HUMAN (1-590): 4.35e-103: 325: 100.00
+	Hs
		679154 TLX1_HUMAN (76-216): 1.68e-37: 136: 31.47		ZN503_HUMAN (32-590): 9.57e-77: 257: 51.75
+	Hs
		641518 PAX6_HUMAN (11-263): 9.74e-32: 123: 16.61		ZN503_HUMAN (32-590): 9.57e-77: 257: 51.75
+	Hs
		829968 HXA1_HUMAN (8-214): 5.44e-31: 119: 24.66		ZN503_HUMAN (32-590): 9.57e-77: 257: 51.75
+	Hs
		620190 PAX7_HUMAN (8-260): 3.22e-29: 116: 15.71		ZN503_HUMAN (32-590): 9.57e-77: 257: 51.75
+	Dm
		976104 HMSH_DROME (34-212): 3.67e-32: 125: 50.00		NOC_DROME (60-584): 3.83e-46: 172: 24.96
+	Dm
		949998 UBX_DROME (4-203): 1.17e-31: 122: 23.30		NOC_DROME (60-584): 3.83e-46: 172: 24.96
+	Hs
		679182 TLX1_HUMAN (76-216): 1.68e-37: 136: 31.47		CHD7_HUMAN (135-489): 2.03e-12: 72.6: 12.95
+	Hs
		679137 TLX1_HUMAN (76-216): 1.68e-37: 136: 31.47		KMT2C_HUMAN (1-571): 1.53e-09: 63.3: 13.10
+	Hs
		641583 PAX6_HUMAN (11-263): 9.74e-32: 123: 16.61		CHD7_HUMAN (135-489): 2.03e-12: 72.6: 12.95
+	Hs
		201848 HXA2_HUMAN (11-265): 2.42e-33: 126: 17.42		SYNJ1_HUMAN (1-548): 4.15e-11: 68.3: 11.99
+	Hs
		203210 PAX6_HUMAN (11-263): 9.74e-32: 123: 16.61		SYNJ1_HUMAN (1-548): 4.15e-11: 68.3: 11.99
+	Hs
		620215 PAX7_HUMAN (8-260): 3.22e-29: 116: 15.71		CHD7_HUMAN (135-489): 2.03e-12: 72.6: 12.95
+	Hs
		641482 PAX6_HUMAN (11-263): 9.74e-32: 123: 16.61		KMT2C_HUMAN (1-571): 1.53e-09: 63.3: 13.10
+	Hs
		620175 PAX7_HUMAN (8-260): 3.22e-29: 116: 15.71		KMT2C_HUMAN (1-571): 1.53e-09: 63.3: 13.10
+	Hs
		213398 TLX2_HUMAN (137-216): 2.18e-11: 64.7: 45.00		CHD7_HUMAN (135-489): 2.03e-12: 72.6: 12.95
+	Hs
		213358 TLX2_HUMAN (137-216): 2.18e-11: 64.7: 45.00		KMT2C_HUMAN (1-571): 1.53e-09: 63.3: 13.10