HitPredict

Interactor 1: VGFR2 (P35968)
Vascular endothelial growth factor receptor 2 (VEGFR-2) (EC 2.7.10.1) (Fetal liver kinase 1) (FLK-1) (Kinase insert domain receptor) (KDR) (Protein-tyrosine kinase receptor flk-1) (CD antigen CD309)
Gene: KDR

Interactor 2: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	10319320, 16966330
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~SH3_1
Common GO terms	GO:0005634 - nucleus GO:0005768 - endosome GO:0005794 - Golgi apparatus GO:0005886 - plasma membrane GO:0043408 - regulation of MAPK cascade
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1356 Hs			1 217
+	Hs
		557625 VGFR2_HUMAN (1-1356): 0: 1028: 100.00		NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14
+	Hs
		412060 VGFR2_HUMAN (1-1356): 0: 1028: 100.00		FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58
+	Hs
		522825 VGFR2_HUMAN (1-1356): 0: 1028: 100.00		SRC_HUMAN (161-215): 3.76e-11: 63.8: 31.58
+	Dm
		112214 M9MRE1_DROME (31-1354): 0: 608: 21.17		GRAP_DROME (1-215): 5.1e-62: 194: 62.79
+	Dm
		112209 M9MRE1_DROME (31-1354): 0: 608: 21.17		ABL_DROME (4-135): 1e-22: 97.4: 37.68
+	Dm
		112231 M9MRE1_DROME (31-1354): 0: 608: 21.17		SRC42_DROME (131-215): 1.35e-11: 65: 19.54
+	Hs
		557088 PGFRA_HUMAN (11-545): 1.02e-53: 207: 19.71		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		452385 PGFRB_HUMAN (33-555): 3.92e-53: 205: 18.45		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		452495 PGFRB_HUMAN (33-555): 3.92e-53: 205: 18.45		VAV3_HUMAN (1-212): 1.16e-43: 157: 22.00
+	Mm
		403421 RET_MOUSE (809-1201): 1.5e-77: 281: 41.01		SRC_MOUSE (161-215): 3.76e-11: 63.8: 31.58
+	Hs
		452344 PGFRB_HUMAN (33-555): 3.92e-53: 205: 18.45		NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14
+	Hs
		337317 PGFRB_HUMAN (33-555): 3.92e-53: 205: 18.45		ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46
+	Hs
		452370 PGFRB_HUMAN (33-555): 3.92e-53: 205: 18.45		ABL2_HUMAN (4-139): 9.61e-22: 94.7: 34.04
+	Rn
		595729 PGFRA_RAT (11-545): 1.25e-56: 217: 19.17		LYN_RAT (129-215): 4.14e-11: 63.4: 23.60
+	Hs
		452342 PGFRB_HUMAN (33-555): 3.92e-53: 205: 18.45		VAV_HUMAN (2-60): 8.95e-15: 74.6: 42.37
+	Hs
		411953 PGFRB_HUMAN (33-555): 3.92e-53: 205: 18.45		FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58
+	Hs
		433221 PGFRB_HUMAN (33-555): 3.92e-53: 205: 18.45		YES_HUMAN (59-215): 4.17e-13: 69.2: 14.91
+	Hs
		452338 PGFRB_HUMAN (33-555): 3.92e-53: 205: 18.45		SRC_HUMAN (161-215): 3.76e-11: 63.8: 31.58
+	Hs
		452375 PGFRB_HUMAN (33-555): 3.92e-53: 205: 18.45		VAV2_HUMAN (3-56): 4.83e-11: 63.5: 38.18
+	Hs
		275165 KIT_HUMAN (15-545): 5.99e-49: 192: 17.46		GRAP2_HUMAN (3-55): 1.58e-10: 61.3: 39.62