HitPredict

Interactor 1: PRS7 (P35998)
26S proteasome regulatory subunit 7 (26S proteasome AAA-ATPase subunit RPT1) (Proteasome 26S subunit ATPase 2)
Gene: PSMC2

Interactor 2: RD23B (P54727)
UV excision repair protein RAD23 homolog B (HR23B) (hHR23B) (XP-C repair-complementing complex 58 kDa protein) (p58)
Gene: RAD23B

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.84	1.00	0.922

Property	Details
Experiments	28539385, 27114451, 16712842, 35271311, 9490418
Identification Methods	pull down, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	AAA~ubiquitin
Common GO terms	GO:0000502 - proteasome complex GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 433 Hs			1 409
+	Rn
		1117330 PRS7_RAT (1-433): 1.19e-143: 418: 99.77		RD23B_RAT (1-409): 1.14e-120: 358: 87.23
+	Hs
		798621 PRS6B_HUMAN (3-425): 2.12e-121: 361: 35.93		RD23B_HUMAN (1-409): 1.31e-125: 370: 100.00
+	Hs
		730224 PRS7_HUMAN (1-433): 3.93e-144: 419: 100.00		RD23A_HUMAN (1-409): 9.12e-94: 287: 56.72
+	Sc
		697108 PRS8_YEAST (16-417): 3.49e-154: 444: 44.53		RAD23_YEAST (1-407): 2.12e-72: 233: 28.41
+	Hs
		798620 PRS6B_HUMAN (3-425): 2.12e-121: 361: 35.93		RD23A_HUMAN (1-409): 9.12e-94: 287: 56.72
+	Hs
		730383 PRS7_HUMAN (1-433): 3.93e-144: 419: 100.00		UBQL1_HUMAN (1-404): 1.25e-57: 200: 13.72
+	Sc
		697067 PRS7_YEAST (1-433): 1.68e-127: 378: 69.59		RAD23_YEAST (1-407): 2.12e-72: 233: 28.41
+	Hs
		730376 PRS7_HUMAN (1-433): 3.93e-144: 419: 100.00		UBQL2_HUMAN (1-364): 5.93e-51: 182: 13.68
+	Hs
		730366 PRS7_HUMAN (1-433): 3.93e-144: 419: 100.00		UBQL4_HUMAN (1-364): 2.75e-45: 166: 12.71
+	Dm
		1181058 Q7KMQ0_DROME (1-433): 1.08e-142: 416: 91.69		Q9VWD9_DROME (1-353): 1.07e-44: 164: 11.08
+	Dm
		820528 PRS4_DROME (1-428): 9.23e-138: 403: 39.30		Q9VWD9_DROME (1-353): 1.07e-44: 164: 11.08
+	Hs
		798782 PRS6B_HUMAN (3-425): 2.12e-121: 361: 35.93		UBQL1_HUMAN (1-404): 1.25e-57: 200: 13.72
+	Mm
		476889 Q8BVQ9_MOUSE (1-433): 7.58e-144: 420: 99.77		UBC_MOUSE (1-118): 1.78e-32: 131: 21.67
+	Hs
		798776 PRS6B_HUMAN (3-425): 2.12e-121: 361: 35.93		UBQL2_HUMAN (1-364): 5.93e-51: 182: 13.68
+	At
		1092378 PRS7A_ARATH (10-433): 7.99e-139: 405: 80.43		UBQ3_ARATH (1-80): 7.66e-29: 116: 28.75
+	Dm
		1181036 Q7KMQ0_DROME (1-433): 1.08e-142: 416: 91.69		Q9VCD5_DROME (1-238): 9.23e-20: 90.7: 19.92
+	Hs
		730236 PRS7_HUMAN (1-433): 3.93e-144: 419: 100.00		RS27A_HUMAN (1-90): 2.4e-15: 75: 26.67
+	Dm
		820508 PRS4_DROME (1-428): 9.23e-138: 403: 39.30		Q9VCD5_DROME (1-238): 9.23e-20: 90.7: 19.92
+	Hs
		474950 PRS6B_HUMAN (3-425): 2.12e-121: 361: 35.93		UBB_HUMAN (1-79): 1.99e-32: 123: 30.38
+	At
		1091962 PRS8A_ARATH (4-430): 1.25e-122: 364: 45.09		UBQ3_ARATH (1-80): 7.66e-29: 116: 28.75