HitPredict

Interactor 1: 1433S (P31947)
14-3-3 protein sigma (Epithelial cell marker protein 1) (Stratifin)
Gene: SFN

Interactor 2: MRCKA (Q5VT25)
Serine/threonine-protein kinase MRCK alpha (EC 2.7.11.1) (CDC42-binding protein kinase alpha) (DMPK-like alpha) (Myotonic dystrophy kinase-related CDC42-binding kinase alpha) (MRCK alpha) (Myotonic dystrophy protein kinase-like alpha)
Gene: CDC42BPA

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	36931259
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	14-3-3~C1_1
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 248 Hs			1 1732
+	Hs
		971623 1433E_HUMAN (2-246): 4.43e-146: 410: 60.41		MRCKA_HUMAN (1-1732): 0: 1630: 100.00
+	Hs
		990331 1433Z_HUMAN (1-242): 8.34e-142: 398: 70.66		MRCKA_HUMAN (1-1732): 0: 1630: 100.00
+	Hs
		691104 1433T_HUMAN (1-238): 1e-107: 312: 71.85		MRCKA_HUMAN (1-1732): 0: 1630: 100.00
+	Hs
		729924 1433B_HUMAN (1-239): 3.42e-100: 293: 68.62		MRCKA_HUMAN (1-1732): 0: 1630: 100.00
+	Hs
		730671 1433S_HUMAN (1-248): 3.5e-158: 440: 100.00		MRCKG_HUMAN (4-1712): 0: 1155: 40.31
+	Hs
		990351 1433Z_HUMAN (1-242): 8.34e-142: 398: 70.66		MRCKG_HUMAN (4-1712): 0: 1155: 40.31
+	Hs
		691123 1433T_HUMAN (1-238): 1e-107: 312: 71.85		MRCKG_HUMAN (4-1712): 0: 1155: 40.31
+	Hs
		728051 1433S_HUMAN (1-248): 3.5e-158: 440: 100.00		AKT1_HUMAN (13-407): 9.62e-129: 413: 31.02
+	At
		1379653 14337_ARATH (2-247): 4.37e-147: 413: 58.07		CIPKC_ARATH (64-525): 1.21e-137: 438: 19.14
+	At
		1030913 14332_ARATH (3-248): 2.24e-144: 405: 58.47		CIPKC_ARATH (64-525): 1.21e-137: 438: 19.14
+	At
		840534 14333_ARATH (3-247): 2.64e-144: 405: 58.30		CIPKC_ARATH (64-525): 1.21e-137: 438: 19.14
+	Hs
		728147 1433E_HUMAN (2-246): 4.43e-146: 410: 60.41		AKT1_HUMAN (13-407): 9.62e-129: 413: 31.02
+	Hs
		972153 1433E_HUMAN (2-246): 4.43e-146: 410: 60.41		ST38L_HUMAN (10-417): 2.89e-126: 405: 38.06
+	Hs
		728155 1433Z_HUMAN (1-242): 8.34e-142: 398: 70.66		AKT1_HUMAN (13-407): 9.62e-129: 413: 31.02
+	Hs
		990252 1433Z_HUMAN (1-242): 8.34e-142: 398: 70.66		STK38_HUMAN (66-404): 1.25e-89: 302: 45.07
+	Hs
		990780 1433Z_HUMAN (1-242): 8.34e-142: 398: 70.66		LATS2_HUMAN (65-376): 3.55e-75: 275: 41.23
+	Hs
		287679 1433Z_HUMAN (1-242): 8.34e-142: 398: 70.66		KS6A5_HUMAN (60-334): 2.61e-72: 261: 27.46
+	Hs
		729856 1433B_HUMAN (1-239): 3.42e-100: 293: 68.62		STK38_HUMAN (66-404): 1.25e-89: 302: 45.07
+	Hs
		971486 1433E_HUMAN (2-246): 4.43e-146: 410: 60.41		ROCK1_HUMAN (372-1052): 2.32e-22: 107: 11.77
+	Mm
		990010 1433Z_MOUSE (1-243): 1.35e-136: 385: 69.96		KS6A5_MOUSE (75-147): 3.33e-12: 73.7: 23.38