HitPredict

Interactor 1: SYUA (P37840)
Alpha-synuclein (Non-A beta component of AD amyloid) (Non-A4 component of amyloid precursor) (NACP)
Gene: SNCA

Interactor 2: SMUF2 (Q9HAU4)
E3 ubiquitin-protein ligase SMURF2 (hSMURF2) (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase SMURF2) (SMAD ubiquitination regulatory factor 2) (SMAD-specific E3 ubiquitin-protein ligase 2)
Gene: SMURF2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	30021006
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 140 Hs			1 748
+	Hs
		742545 SYUA_HUMAN (1-140): 5.01e-57: 175: 100.00		SMUF1_HUMAN (1-748): 0: 748: 70.44
+	Hs
		742119 SYUA_HUMAN (1-140): 5.01e-57: 175: 100.00		NEDD4_HUMAN (104-746): 0: 628: 38.73
+	Hs
		742479 SYUA_HUMAN (1-140): 5.01e-57: 175: 100.00		NED4L_HUMAN (5-396): 1.96e-36: 149: 18.58
+	Hs
		125201 SYUA_HUMAN (1-140): 5.01e-57: 175: 100.00		WWP2_HUMAN (1-416): 7.64e-26: 116: 17.39