HitPredict

Interactor 1: MRP1 (P33527)
Multidrug resistance-associated protein 1 (EC 7.6.2.2) (ATP-binding cassette sub-family C member 1) (Glutathione-S-conjugate-translocating ATPase ABCC1) (EC 7.6.2.3) (Leukotriene C(4) transporter) (LTC4 transporter)
Gene: ABCC1

Interactor 2: CXCR4 (P61073)
C-X-C chemokine receptor type 4 (CXC-R4) (CXCR-4) (FB22) (Fusin) (HM89) (LCR1) (Leukocyte-derived seven transmembrane domain receptor) (LESTR) (Lipopolysaccharide-associated protein 3) (LAP-3) (LPS-associated protein 3) (NPYRL) (Stromal cell-derived factor 1 receptor) (SDF-1 receptor) (CD antigen CD184)
Gene: CXCR4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	unassigned3799
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0060326 - cell chemotaxis GO:0070062 - extracellular exosome
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 1531 Hs			1 352
+	Hs
		753783 MRP1_HUMAN (1-1531): 0: 1273: 100.00		CXCR3_HUMAN (10-350): 1.54e-83: 259: 34.01
+	Hs
		753786 MRP1_HUMAN (1-1531): 0: 1273: 100.00		CCR9_HUMAN (9-349): 6.91e-71: 227: 31.21
+	Hs
		669301 MRP1_HUMAN (1-1531): 0: 1273: 100.00		ACKR3_HUMAN (41-310): 6.48e-47: 164: 31.05
+	Hs
		467245 MDR1_HUMAN (241-871): 3.31e-112: 388: 17.15		CCR6_HUMAN (2-349): 1.83e-68: 220: 30.34
+	Hs
		190597 MRP4_HUMAN (255-910): 1.23e-66: 250: 15.46		CXCR4_HUMAN (1-336): 5.07e-84: 260: 100.00
+	Hs
		190593 MRP4_HUMAN (255-910): 1.23e-66: 250: 15.46		CXCR3_HUMAN (10-350): 1.54e-83: 259: 34.01
+	Hs
		190595 MRP4_HUMAN (255-910): 1.23e-66: 250: 15.46		CCR9_HUMAN (9-349): 6.91e-71: 227: 31.21
+	Hs
		190591 MRP4_HUMAN (255-910): 1.23e-66: 250: 15.46		OPRX_HUMAN (26-334): 8.87e-65: 211: 25.31