HitPredict

Interactor 1: IF4A3 (P38919)
Eukaryotic initiation factor 4A-III (eIF-4A-III) (eIF4A-III) (EC 3.6.4.13) (ATP-dependent RNA helicase DDX48) (ATP-dependent RNA helicase eIF4A-3) (DEAD box protein 48) (Eukaryotic initiation factor 4A-like NUK-34) (Eukaryotic translation initiation factor 4A isoform 3) (Nuclear matrix protein 265) (NMP 265) (hNMP 265) [Cleaved into: Eukaryotic initiation factor 4A-III, N-terminally processed]
Gene: EIF4A3

Interactor 2: SRS12 (Q8WXF0)
Serine/arginine-rich splicing factor 12 (35 kDa SR repressor protein) (SRrp35) (Splicing factor, arginine/serine-rich 13B) (Splicing factor, arginine/serine-rich 19)
Gene: SRSF12

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	23084401
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000398 - mRNA splicing, via spliceosome GO:0003723 - RNA binding GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0016607 - nuclear speck
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 411 Hs			1 261
+	Hs
		266946 IF4A1_HUMAN (7-411): 1.67e-178: 505: 66.75		SRS10_HUMAN (1-229): 6.35e-34: 125: 50.00
+	At
		97541 F4JEL4_ARATH (1-389): 4.02e-180: 509: 65.47		RBG7_ARATH (5-87): 1.09e-31: 116: 32.53
+	Hs
		892791 IF4A1_HUMAN (7-411): 1.67e-178: 505: 66.75		PABP4_HUMAN (2-101): 2.19e-20: 92.1: 18.00
+	Hs
		516434 IF4A1_HUMAN (7-411): 1.67e-178: 505: 66.75		PABP1_HUMAN (2-101): 3.98e-19: 88.3: 17.00
+	Hs
		1031325 IF4A2_HUMAN (20-411): 4.07e-177: 501: 69.47		PABP4_HUMAN (2-101): 2.19e-20: 92.1: 18.00
+	Hs
		516515 IF4A2_HUMAN (20-411): 4.07e-177: 501: 69.47		PABP1_HUMAN (2-101): 3.98e-19: 88.3: 17.00
+	Mm
		857295 IF4A1_MOUSE (7-411): 1.67e-178: 505: 66.75		TIA1_MOUSE (5-100): 2.05e-17: 82.5: 17.71
+	Sc
		376792 DHH1_YEAST (39-408): 1.26e-169: 486: 40.54		PABP_YEAST (2-98): 1.48e-20: 92.5: 22.68
+	Hs
		757802 IF4A3_HUMAN (1-411): 1.22e-142: 414: 100.00		PPIE_HUMAN (10-98): 7.46e-34: 126: 33.71
+	Hs
		266930 IF4A3_HUMAN (1-411): 1.22e-142: 414: 100.00		SRS10_HUMAN (1-229): 6.35e-34: 125: 50.00
+	Hs
		571634 DDX5_HUMAN (25-411): 6.87e-135: 401: 30.63		PPIE_HUMAN (10-98): 7.46e-34: 126: 33.71
+	Hs
		1271695 DDX17_HUMAN (14-411): 1.24e-132: 399: 30.79		PPIE_HUMAN (10-98): 7.46e-34: 126: 33.71
+	Hs
		757567 IF4A3_HUMAN (1-411): 1.22e-142: 414: 100.00		SRSF3_HUMAN (1-92): 1.68e-23: 95: 32.61
+	Hs
		757573 IF4A3_HUMAN (1-411): 1.22e-142: 414: 100.00		SRSF2_HUMAN (4-90): 1.12e-22: 94.6: 45.65
+	Hs
		516391 IF4A3_HUMAN (1-411): 1.22e-142: 414: 100.00		PABP1_HUMAN (2-101): 3.98e-19: 88.3: 17.00
+	Mm
		857351 Q8BTS0_MOUSE (25-411): 7.07e-135: 401: 30.63		TIA1_MOUSE (5-100): 2.05e-17: 82.5: 17.71
+	Mm
		857323 DDX17_MOUSE (14-411): 1.34e-133: 399: 30.79		TIA1_MOUSE (5-100): 2.05e-17: 82.5: 17.71
+	Sc
		376580 DED1_YEAST (6-411): 3.66e-130: 388: 32.00		PABP_YEAST (2-98): 1.48e-20: 92.5: 22.68
+	Mm
		936480 DDX5_MOUSE (25-411): 6.87e-135: 401: 30.63		TIAR_MOUSE (4-98): 9.83e-15: 74.8: 15.46
+	Hs
		757632 IF4A3_HUMAN (1-411): 1.22e-142: 414: 100.00		SRSF7_HUMAN (1-108): 2.53e-09: 58.2: 35.78