HitPredict

Interactor 1: ITSN1 (Q15811)
Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17)
Gene: ITSN1

Interactor 2: EP15R (Q9UBC2)
Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R)
Gene: EPS15L1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.94	0.60	0.752

Property	Details
Experiments	33961781, 31839598, 40437099, 32203420, 35271311, 35914814, 37071682, 22558309, unassigned2213
Identification Methods	affinity chromatography technology, cross-linking study, two hybrid, anti tag coimmunoprecipitation, two hybrid fragment pooling approach
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005509 - calcium ion binding GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0016197 - endosomal transport
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 1721 Hs			1 864
+	Hs
		839768 ITSN1_HUMAN (1-1721): 0: 879: 100.00		EPS15_HUMAN (1-862): 3.26e-109: 358: 41.50
+	Cl
		47464 F1PHV6_CANLF (1-1721): 0: 886: 97.21		A0A8I3PJA6_CANLF (1-862): 4.53e-101: 336: 41.45
+	Mm
		839864 ITSN1_MOUSE (1-1721): 0: 846: 94.65		EPS15_MOUSE (1-862): 6.4e-93: 314: 41.19
+	Hs
		1453438 ITSN2_HUMAN (1-1720): 0: 693: 55.48		EP15R_HUMAN (1-864): 2.18e-146: 455: 100.00
+	Hs
		64409 A6H8W8_HUMAN (1-1720): 0: 692: 56.86		EP15R_HUMAN (1-864): 2.18e-146: 455: 100.00
+	Hs
		839838 ITSN2_HUMAN (1-1720): 0: 693: 55.48		EPS15_HUMAN (1-862): 3.26e-109: 358: 41.50
+	Hs
		64403 A6H8W8_HUMAN (1-1720): 0: 692: 56.86		EPS15_HUMAN (1-862): 3.26e-109: 358: 41.50
+	Hs
		1154087 ITSN1_HUMAN (1-1721): 0: 879: 100.00		ITSN1_HUMAN (1-556): 5.64e-32: 137: 12.77
+	Hs
		1154182 ITSN1_HUMAN (1-1721): 0: 879: 100.00		ITSN2_HUMAN (2-545): 6.29e-25: 114: 13.09
+	Hs
		1154134 ITSN1_HUMAN (1-1721): 0: 879: 100.00		REPS2_HUMAN (14-99): 2.32e-12: 72.7: 24.42
+	Hs
		1087004 ITSN1_HUMAN (1-1721): 0: 879: 100.00		KIF5A_HUMAN (341-776): 3.98e-11: 69.3: 11.88
+	Mm
		1221960 ITSN1_MOUSE (1-1721): 0: 846: 94.65		EP15R_MOUSE (496-864): 8.27e-14: 77.8: 15.99
+	Rn
		97303 ITSN1_RAT (1-1721): 0: 832: 94.25		E9PSY8_RAT (9-307): 9.61e-15: 80.8: 15.00
+	Hs
		1453434 ITSN2_HUMAN (1-1720): 0: 693: 55.48		ITSN2_HUMAN (2-545): 6.29e-25: 114: 13.09
+	Hs
		539965 BCR_HUMAN (756-1682): 2.32e-73: 271: 12.91		EPS15_HUMAN (1-862): 3.26e-109: 358: 41.50
+	Rn
		236529 KALRN_RAT (84-1641): 3.87e-76: 283: 11.43		MRCKA_RAT (202-844): 5.18e-31: 134: 9.21
+	Hs
		1154138 PREX1_HUMAN (1190-1621): 1.41e-72: 271: 18.89		ITSN1_HUMAN (1-556): 5.64e-32: 137: 12.77
+	Hs
		772966 ARHGH_HUMAN (976-1711): 3.47e-89: 325: 13.99		MYH9_HUMAN (362-572): 2.38e-11: 69.9: 15.07
+	Rn
		1022058 KALRN_RAT (84-1641): 3.87e-76: 283: 11.43		MRCKB_RAT (195-570): 3.34e-11: 69.7: 11.52