HitPredict

Interactor 1: FYN (P39688)
Tyrosine-protein kinase Fyn (EC 2.7.10.2) (Proto-oncogene c-Fyn) (p59-Fyn)
Gene: FYN

Interactor 2: BCAR1 (Q61140)
Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas)
Gene: BCAR1

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.55	1.00	0.743

Property	Details
Experiments	17875741, 15102471
Identification Methods	affinity chromatography technology, two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH3_1, SH2~SH3_1, SH3_1~SH3_1
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0007169 - cell surface receptor protein tyrosine kinase signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 537 Mm			1 874
+	Rn
		1144044 FYN_RAT (1-537): 0: 632: 99.81		BCAR1_RAT (4-874): 3.46e-121: 392: 96.90
+	Hs
		412110 FYN_HUMAN (1-537): 0: 634: 99.44		BCAR1_HUMAN (1-874): 5.26e-120: 386: 90.16
+	Hs
		412193 FYN_HUMAN (1-537): 0: 634: 99.44		CASL_HUMAN (1-872): 1.49e-112: 365: 35.77
+	Mm
		403441 SRC_MOUSE (1-537): 0: 594: 68.52		BCAR1_MOUSE (1-874): 3.19e-123: 395: 100.00
+	Rn
		1144372 SRC_RAT (1-537): 0: 594: 68.33		BCAR1_RAT (4-874): 3.46e-121: 392: 96.90
+	Hs
		522874 SRC_HUMAN (1-537): 0: 592: 68.76		BCAR1_HUMAN (1-874): 5.26e-120: 386: 90.16
+	Hs
		433301 YES_HUMAN (1-537): 0: 581: 72.16		BCAR1_HUMAN (1-874): 5.26e-120: 386: 90.16
+	Hs
		442799 HCK_HUMAN (1-535): 0: 571: 56.26		BCAR1_HUMAN (1-874): 5.26e-120: 386: 90.16
+	Hs
		412366 FYN_HUMAN (1-537): 0: 634: 99.44		CASS4_HUMAN (4-869): 3.43e-51: 195: 22.02
+	Hs
		412296 FYN_HUMAN (1-537): 0: 634: 99.44		SH3K1_HUMAN (7-368): 6.95e-24: 109: 14.40
+	Hs
		522749 SRC_HUMAN (1-537): 0: 592: 68.76		MUC1_HUMAN (55-659): 1.32e-31: 135: 11.29
+	Hs
		199497 FYN_HUMAN (1-537): 0: 634: 99.44		EFS_HUMAN (5-214): 2.33e-13: 75.7: 29.55
+	Hs
		523104 SRC_HUMAN (1-537): 0: 592: 68.76		SH3K1_HUMAN (7-368): 6.95e-24: 109: 14.40
+	Hs
		411582 LCK_HUMAN (74-535): 0: 547: 61.04		MUC1_HUMAN (55-659): 1.32e-31: 135: 11.29
+	Hs
		442869 HCK_HUMAN (1-535): 0: 571: 56.26		SH3K1_HUMAN (7-368): 6.95e-24: 109: 14.40
+	Hs
		454842 FGR_HUMAN (1-535): 0: 569: 69.57		SH3K1_HUMAN (7-368): 6.95e-24: 109: 14.40
+	Mm
		403448 SRC_MOUSE (1-537): 0: 594: 68.52		EFS_MOUSE (5-305): 2.38e-13: 75.7: 21.82
+	Hs
		199500 SRC_HUMAN (1-537): 0: 592: 68.76		EFS_HUMAN (5-214): 2.33e-13: 75.7: 29.55
+	Hs
		199498 YES_HUMAN (1-537): 0: 581: 72.16		EFS_HUMAN (5-214): 2.33e-13: 75.7: 29.55
+	Hs
		203198 LCK_HUMAN (74-535): 0: 547: 61.04		SYNJ1_HUMAN (320-739): 2.9e-11: 69.9: 9.49