Protein: YETS2
YEATS domain-containing protein 2

Gene: YETS2, YEATS2
Organism: Homo sapiens
Interactions: 172
UniProt ID: Q9ULM3

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0003714 - transcription corepressor activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0006338 - chromatin remodeling

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1389707

SGF29
SAGA-associated factor 29

9

1

Small-scale

0.752

High

965326

WDR5
WD repeat-containing protein 5

8

18

Small-scale

0.750

High

284897

TADA3
Transcriptional adapter 3

7

2

Small-scale

0.742

High

1449160

MBIP1
MAP3K12-binding inhibitory protein 1

7

2

Small-scale

0.742

High

610506

PRS6A
26S proteasome regulatory subunit 6A

4

1

High-throughput

0.691

High

848838

MAGAA
Melanoma-associated antigen 10

4

3

High-throughput

0.691

High

1436242

CSR2B
Cysteine-rich protein 2-binding protein

4

10

Small-scale

0.686

High

1369177

KAT2A
Histone acetyltransferase KAT2A

4

20

Small-scale

0.676

High

1031968

NC2B
Protein Dr1

3

5

Small-scale

0.674

High

960608

PSME3
Proteasome activator complex subunit 3

3

2

High-throughput

0.667

High

1461647

CARD8
Caspase recruitment domain-containing protein 8

3

1

High-throughput

0.667

High

283569

TAD2A
Transcriptional adapter 2-alpha

3

14

Small-scale

0.640

High

373472

MYC
Myc proto-oncogene protein

3

16

High-throughput

0.640

High

1315074

ZZZ3
ZZ-type zinc finger-containing protein 3

3

2

Small-scale

0.640

High

1369222

KAT2B
Histone acetyltransferase KAT2B

3

18

Small-scale

0.640

High

681950

RBTN2
Rhombotin-2

2

20

High-throughput

0.628

High

1434729

IKZF5
Zinc finger protein Pegasus

2

10

High-throughput

0.628

High

1447936

DPOE4
DNA polymerase epsilon subunit 4

2

2

Small-scale

0.611

High

1200085

EIPR1
EARP and GARP complex-interacting protein 1

3

19

High-throughput

0.609

High

1257264

RFPLB
Ret finger protein-like 4B

3

4

High-throughput

0.609

High

414831

P53
Cellular tumor antigen p53

2

10

High-throughput

0.584

High

1145561

RBBP5
Retinoblastoma-binding protein 5

2

20

High-throughput

0.584

High

1314482

SLX4
Structure-specific endonuclease subunit SLX4

2

17

High-throughput

0.584

High

1339033

NUP43
Nucleoporin Nup43

2

20

High-throughput

0.584

High

1215529

CE162
Centrosomal protein of 162 kDa

2

7

High-throughput

0.571

High

628857

TBP
TATA-box-binding protein

1

2

Small-scale

0.561

High

1430809

CAD19
Cadherin-19

2

2

High-throughput

0.558

High

502173

H2AZ
Histone H2A.Z

1

13

High-throughput

0.536

High

658511

MYF6
Myogenic factor 6

1

5

High-throughput

0.536

High

668068

CDK2
Cyclin-dependent kinase 2

1

8

High-throughput

0.536

High

953178

ACTB
Actin, cytoplasmic 1

1

17

High-throughput

0.536

High

1005240

RNF4
E3 ubiquitin-protein ligase RNF4

1

1

High-throughput

0.536

High

1054668

PSME1
Proteasome activator complex subunit 1

1

2

High-throughput

0.536

High

1093085

CDC16
Cell division cycle protein 16 homolog

1

10

High-throughput

0.536

High

1099820

MD2L1
Mitotic spindle assembly checkpoint protein MAD2A

1

3

High-throughput

0.536

High

1123177

FHL2
Four and a half LIM domains protein 2

1

4

High-throughput

0.536

High

1156345

HSPB2
Heat shock protein beta-2

1

1

High-throughput

0.536

High

1163284

H2B2E
Histone H2B type 2-E

1

20

High-throughput

0.536

High

1324613

PIAS4
E3 SUMO-protein ligase PIAS4

1

3

High-throughput

0.536

High

1385984

ZN653
Zinc finger protein 653

1

4

High-throughput

0.536

High

1460726

CDC23
Cell division cycle protein 23 homolog

1

10

High-throughput

0.536

High

1461645

RUVB2
RuvB-like 2

1

12

High-throughput

0.536

High

831636

CCNF
Cyclin-F

1

2

High-throughput

0.515

High

961654

PHS
Pterin-4-alpha-carbinolamine dehydratase

1

0

High-throughput

0.513

High

1233817

CNDH2
Condensin-2 complex subunit H2

1

0

High-throughput

0.513

High

1367913

THRSP
Thyroid hormone-inducible hepatic protein

1

0

High-throughput

0.513

High

1382493

T53I1
Tumor protein p53-inducible nuclear protein 1

1

0

High-throughput

0.513

High

1451797

HYPK
Huntingtin-interacting protein K

1

0

High-throughput

0.513

High

347408

BAG2
BAG family molecular chaperone regulator 2

1

3

High-throughput

0.489

High

1203831

TTMP
TPA-induced transmembrane protein

1

1

High-throughput

0.489

High

1323708

CRBG2
Beta/gamma crystallin domain-containing protein 2

1

6

High-throughput

0.489

High

1402737

TCPQM
T-complex protein 1 subunit theta-like 2

1

3

High-throughput

0.489

High

71484

P20L1
PHD finger protein 20-like protein 1

1

4

High-throughput

0.479

High

175947

SET1A
Histone-lysine N-methyltransferase SETD1A

1

20

High-throughput

0.479

High

194628

KDM6A
Lysine-specific demethylase 6A

1

12

High-throughput

0.479

High

238638

RAD21
Double-strand-break repair protein rad21 homolog

1

4

High-throughput

0.479

High

247026

KDM1A
Lysine-specific histone demethylase 1A

1

14

High-throughput

0.479

High

283631

SUPT3
Transcription initiation protein SPT3 homolog

1

3

High-throughput

0.479

High

284992

TAF5L
TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L

1

20

High-throughput

0.479

High

317035

MTA2
Metastasis-associated protein MTA2

1

13

High-throughput

0.479

High

323602

TRI37
E3 ubiquitin-protein ligase TRIM37

1

11

High-throughput

0.479

High

337410

PARN
Poly(A)-specific ribonuclease PARN

1

1

High-throughput

0.479

High

339890

KLF8
Krueppel-like factor 8

1

20

High-throughput

0.479

High

378525

IL1A
Interleukin-1 alpha

1

3

Small-scale

0.479

High

404538

GCR
Glucocorticoid receptor

1

20

High-throughput

0.479

High

583020

EZRI
Ezrin

1

17

High-throughput

0.479

High

590016

RFA2
Replication protein A 32 kDa subunit

1

8

High-throughput

0.479

High

675723

TYY1
Transcriptional repressor protein YY1

1

11

High-throughput

0.479

High

696846

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

9

High-throughput

0.479

High

714516

PML
Protein PML

1

14

High-throughput

0.479

High

769494

RFA3
Replication protein A 14 kDa subunit

1

6

High-throughput

0.479

High

800591

VATA
V-type proton ATPase catalytic subunit A

1

1

High-throughput

0.479

High

834091

HNF4A
Hepatocyte nuclear factor 4-alpha

1

20

High-throughput

0.479

High

851699

GATA4
Transcription factor GATA-4

1

15

High-throughput

0.479

High

879607

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

15

High-throughput

0.479

High

881626

CDK8
Cyclin-dependent kinase 8

1

11

High-throughput

0.479

High

887324

CEBPA
CCAAT/enhancer-binding protein alpha

1

18

High-throughput

0.479

High

905512

HCFC1
Host cell factor 1

1

11

High-throughput

0.479

High

928362

ATN1
Atrophin-1

1

20

High-throughput

0.479

High

980529

H4
Histone H4

1

13

High-throughput

0.479

High

986810

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

6

High-throughput

0.479

High

1029171

E2F1
Transcription factor E2F1

1

4

High-throughput

0.479

High

1032065

TFAP4
Transcription factor AP-4

1

3

Small-scale

0.479

High

1033815

PO5F1
POU domain, class 5, transcription factor 1

1

16

High-throughput

0.479

High

1041618

KMT2A
Histone-lysine N-methyltransferase 2A

1

20

High-throughput

0.479

High

1065684

RBL2
Retinoblastoma-like protein 2

1

1

High-throughput

0.479

High

1083459

CPSF1
Cleavage and polyadenylation specificity factor subunit 1

1

3

High-throughput

0.479

High

1096859

RFA4
Replication protein A 30 kDa subunit

1

8

High-throughput

0.479

High

1097627

CBX3
Chromobox protein homolog 3

1

12

High-throughput

0.479

High

1100528

TIF1B
Transcription intermediary factor 1-beta

1

15

High-throughput

0.479

High

1103442

CTBP1
C-terminal-binding protein 1

1

5

High-throughput

0.479

High

1108274

SQSTM
Sequestosome-1

1

2

High-throughput

0.479

High

1110184

HDAC1
Histone deacetylase 1

1

7

High-throughput

0.479

High

1114637

CUL3
Cullin-3

1

11

High-throughput

0.479

High

1122193

UBP2L
Ubiquitin-associated protein 2-like

1

16

Small-scale

0.479

High

1159345

TAF9
Transcription initiation factor TFIID subunit 9

1

2

High-throughput

0.479

High

1241522

EDC4
Enhancer of mRNA-decapping protein 4

1

14

High-throughput

0.479

High

1276120

KANL1
KAT8 regulatory NSL complex subunit 1

1

1

High-throughput

0.479

High

1276956

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

11

High-throughput

0.479

High

1287335

TAD2B
Transcriptional adapter 2-beta

1

13

High-throughput

0.479

High

1289714

NAA40
N-alpha-acetyltransferase 40

1

4

High-throughput

0.479

High

1313522

SMC5
Structural maintenance of chromosomes protein 5

1

11

High-throughput

0.479

High

1339229

NUP35
Nucleoporin NUP35

1

3

High-throughput

0.479

High

1367571

ESR2
Estrogen receptor beta

1

20

High-throughput

0.479

High

1384476

PF21A
PHD finger protein 21A

1

18

High-throughput

0.479

High

1387636

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

18

High-throughput

0.479

High

1390190

MCRS1
Microspherule protein 1

1

1

High-throughput

0.479

High

1415300

PHF20
PHD finger protein 20

1

11

High-throughput

0.479

High

1420478

DPY30
Protein dpy-30 homolog

1

3

High-throughput

0.479

High

1429013

WWTR1
WW domain-containing transcription regulator protein 1

1

12

High-throughput

0.479

High

1432725

TXNIP
Thioredoxin-interacting protein

1

4

Small-scale

0.479

High

1435967

KAT8
Histone acetyltransferase KAT8

1

9

High-throughput

0.479

High

1437168

KANL2
KAT8 regulatory NSL complex subunit 2

1

2

High-throughput

0.479

High

1437238

NANOG
Homeobox protein NANOG

1

20

High-throughput

0.479

High

1438403

TAF9B
Transcription initiation factor TFIID subunit 9B

1

2

High-throughput

0.479

High

1447005

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

1

Small-scale

0.479

High

1448444

DPOE3
DNA polymerase epsilon subunit 3

1

5

Small-scale

0.479

High

1450949

NLE1
Notchless protein homolog 1

1

13

High-throughput

0.479

High

1452475

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

5

High-throughput

0.479

High

1454060

CXXC1
CXXC-type zinc finger protein 1

1

14

High-throughput

0.479

High

1454738

KANL3
KAT8 regulatory NSL complex subunit 3

1

2

High-throughput

0.479

High

1454808

RERE
Arginine-glutamic acid dipeptide repeats protein

1

20

High-throughput

0.479

High

1458469

ASH2L
Set1/Ash2 histone methyltransferase complex subunit ASH2

1

13

High-throughput

0.479

High

1458825

ZMYM2
Zinc finger MYM-type protein 2

1

3

High-throughput

0.479

High

1460286

XPO7
Exportin-7

1

8

High-throughput

0.479

High

1461130

RCOR1
REST corepressor 1

1

14

High-throughput

0.479

High

1461306

NUP50
Nuclear pore complex protein Nup50

1

7

High-throughput

0.479

High

1461506

BRPF3
Bromodomain and PHD finger-containing protein 3

1

12

High-throughput

0.479

High

1461535

ZN608
Zinc finger protein 608

1

6

High-throughput

0.479

High

1461642

MYO6
Unconventional myosin-VI

1

1

High-throughput

0.479

High

1461643

KMT2B
Histone-lysine N-methyltransferase 2B

1

20

High-throughput

0.479

High

1461644

SET1B
Histone-lysine N-methyltransferase SETD1B

1

20

High-throughput

0.479

High

1461646

ASF1A
Histone chaperone ASF1A

1

5

High-throughput

0.479

High

1461648

WDR37
WD repeat-containing protein 37

1

20

High-throughput

0.479

High

1461649

TRRAP
Transformation/transcription domain-associated protein

1

12

High-throughput

0.479

High

1461650

HCFC2
Host cell factor 2

1

10

High-throughput

0.479

High

1461651

TAF6L
TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L

1

1

High-throughput

0.479

High

995890

ACTC
Actin, alpha cardiac muscle 1

1

12

High-throughput

0.470

High

214064

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

0

Small-scale

0.458

High

319184

ST65G
STAGA complex 65 subunit gamma

1

0

High-throughput

0.458

High

961887

RL37A
Large ribosomal subunit protein eL43

1

0

High-throughput

0.458

High

1244846

FBX38
F-box only protein 38

1

0

High-throughput

0.458

High

1277964

NUFP2
FMR1-interacting protein NUFIP2

1

0

High-throughput

0.458

High

1337592

SP20H
Transcription factor SPT20 homolog

1

0

High-throughput

0.458

High

1364012

SMG7
Nonsense-mediated mRNA decay factor SMG7

1

0

High-throughput

0.458

High

1384793

TADA1
Transcriptional adapter 1

1

0

High-throughput

0.458

High

138536

BIN1
Myc box-dependent-interacting protein 1

1

4

High-throughput

0.457

High

1404498

CDC5L
Cell division cycle 5-like protein

1

7

High-throughput

0.457

High

1461046

TNIK
TRAF2 and NCK-interacting protein kinase

1

8

High-throughput

0.457

High

1199749

KLH22
Kelch-like protein 22

1

5

High-throughput

0.445

High

400040

CATA
Catalase

1

1

High-throughput

0.437

High

1241982

FBX42
F-box only protein 42

1

12

High-throughput

0.437

High

1252289

SYNE3
Nesprin-3

1

6

High-throughput

0.437

High

1331576

CE120
Centrosomal protein of 120 kDa

1

8

High-throughput

0.437

High

1360844

ASB11
Ankyrin repeat and SOCS box protein 11

1

5

High-throughput

0.437

High

1434213

PKHA4
Pleckstrin homology domain-containing family A member 4

1

12

High-throughput

0.437

High

640325

EPHA1
Ephrin type-A receptor 1

1

2

High-throughput

0.417

High

1396490

Q96KY9
CDH19 protein

1

3

High-throughput

0.407

High

931214

BCAT1
Branched-chain-amino-acid aminotransferase, cytosolic

3

0

High-throughput

0.347

High

1162755

KAT1
Kynurenine--oxoglutarate transaminase 1

2

0

High-throughput

0.328

High

1332454

CBY2
Protein chibby homolog 2

2

0

High-throughput

0.328

High

549712

PRPS2
Ribose-phosphate pyrophosphokinase 2

1

0

High-throughput

0.279

Low

1330146

PCD20
Protocadherin-20

1

0

High-throughput

0.279

Low

1390370

I17RA
Interleukin-17 receptor A

1

0

High-throughput

0.279

Low

1409650

DHB14
L-fucose dehydrogenase

1

0

High-throughput

0.279

Low

1420130

NMNA2
Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2

1

0

High-throughput

0.279

Low

1431483

CAD23
Cadherin-23

1

0

High-throughput

0.279

Low

1025966

NDP
Norrin

1

0

Small-scale

0.249

Low

1385717

ENTR1
Endosome-associated-trafficking regulator 1

1

0

High-throughput

0.249

Low

239249

ZNRD2
Protein ZNRD2

1

0

High-throughput

0.232

Low

1399075

TMM74
Transmembrane protein 74

1

0

High-throughput

0.232

Low

1432304

SO5A1
Solute carrier organic anion transporter family member 5A1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025