HitPredict

Interactor 1: SNF7 (P39929)
Vacuolar-sorting protein SNF7 (DOA4-independent degradation protein 1) (Sucrose nonfermenting protein 7) (Vacuolar protein-sorting-associated protein 32)
Gene: SNF7

Interactor 2: VPS60 (Q03390)
Vacuolar protein-sorting-associated protein 60 (Charged multivesicular body protein 5)
Gene: VPS60

Species: Saccharomyces cerevisiae S288C

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.89	1.00	0.946

Property	Details
Experiments	18467557, 35445263, 19591838, 37968396, 31273031, 22875988
Identification Methods	protein complementation assay, affinity chromatography technology, pull down, two hybrid, dihydrofolate reductase reconstruction
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Snf7~Snf7
Common GO terms	GO:0005737 - cytoplasm GO:0005771 - multivesicular body GO:0006900 - vesicle budding from membrane GO:0015031 - protein transport GO:0032511 - late endosome to vacuole transport via multivesicular body sorting pathway
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 240 Sc			1 229
+	Hs
		92838 E9PSI1_HUMAN (2-214): 2.14e-52: 183: 33.33		CHM4B_HUMAN (15-220): 3.6e-38: 133: 19.42
+	Zm
		77175 B4FU00_MAIZE (2-230): 3.95e-37: 131: 18.88		B4FU00_MAIZE (1-229): 3.32e-47: 157: 25.43
+	Hs
		1260649 CHMP7_HUMAN (8-234): 5.77e-38: 139: 21.03		CHM4C_HUMAN (1-229): 1.15e-40: 140: 17.75
+	At
		98408 F4JXR3_ARATH (2-219): 7.18e-42: 145: 17.24		VP322_ARATH (1-227): 5e-38: 133: 19.30
+	At
		1339085 VP601_ARATH (2-219): 5.19e-41: 141: 19.20		VP322_ARATH (1-227): 5e-38: 133: 19.30
+	Ce
		1090380 Q9U2F6_CAEEL (2-237): 5.05e-36: 129: 13.75		Q18886_CAEEL (2-222): 2.41e-42: 144: 19.46
+	Hs
		1260658 CHMP7_HUMAN (8-234): 5.77e-38: 139: 21.03		CHM4A_HUMAN (1-229): 8.6e-38: 133: 18.34
+	Hs
		1260663 CHMP7_HUMAN (8-234): 5.77e-38: 139: 21.03		CHM4B_HUMAN (15-220): 3.6e-38: 133: 19.42
+	Hs
		1286650 CHM4C_HUMAN (3-229): 8.48e-37: 131: 34.80		CHM4C_HUMAN (1-229): 1.15e-40: 140: 17.75
+	Sc
		764842 SNF7_YEAST (1-240): 3.44e-42: 145: 100.00		SNF7_YEAST (4-226): 1.29e-34: 125: 20.98
+	Ce
		183904 Q18886_CAEEL (4-221): 2.96e-36: 129: 30.00		O16458_CAEEL (1-218): 1.81e-40: 139: 27.06
+	At
		287073 VP601_ARATH (2-219): 5.19e-41: 141: 19.20		VP321_ARATH (1-220): 8.32e-36: 127: 16.82
+	Sc
		764888 SNF7_YEAST (1-240): 3.44e-42: 145: 100.00		VPS20_YEAST (6-227): 1.29e-33: 122: 17.12
+	Hs
		1286687 CHM4C_HUMAN (3-229): 8.48e-37: 131: 34.80		CHM4A_HUMAN (1-229): 8.6e-38: 133: 18.34
+	Hs
		1286698 CHM4C_HUMAN (3-229): 8.48e-37: 131: 34.80		CHM4B_HUMAN (15-220): 3.6e-38: 133: 19.42
+	Hs
		1316082 CHMP5_HUMAN (2-199): 2.27e-35: 126: 27.23		CHM4A_HUMAN (1-229): 8.6e-38: 133: 18.34
+	Hs
		1330527 CHMP5_HUMAN (2-199): 2.27e-35: 126: 27.23		CHM4B_HUMAN (15-220): 3.6e-38: 133: 19.42
+	At
		1013158 VP601_ARATH (2-219): 5.19e-41: 141: 19.20		VPS2B_ARATH (8-194): 1.08e-12: 66.8: 13.90
+	At
		1013164 VPS2A_ARATH (1-236): 2.07e-40: 140: 16.95		VPS2B_ARATH (8-194): 1.08e-12: 66.8: 13.90