HitPredict

Interactor 1: STAT3 (P40763)
Signal transducer and activator of transcription 3 (Acute-phase response factor)
Gene: STAT3

Interactor 2: KSYK (P43405)
Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase) (p72-Syk)
Gene: SYK

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.89 1.00 0.949

The method score is based on:

Property Details
Experiments 25416956, 21516116, 32296183, 20133729, unassigned1304, 31515488
Identification Methods two hybrid, anti bait coimmunoprecipitation, validated two hybrid, two hybrid prey pooling approach, two hybrid array
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains PK_Tyr_Ser-Thr~SH2, SH2~SH2
Common GO terms GO:0005102 - signaling receptor binding
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0005886 - plasma membrane
and 7 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 770
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024