Protein: TUP1
General transcriptional corepressor TUP1 (Flocculation suppressor protein) (Glucose repression regulatory protein TUP1) (Repressor AER2)

Gene: TUP1
Organism: Saccharomyces cerevisiae S288C
Interactions: 121
UniProt ID: P16649

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000209 - protein polyubiquitination
GO:0000278 - mitotic cell cycle
GO:0003714 - transcription corepressor activity
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

598369

TUP1
General transcriptional corepressor TUP1

4

18

Small-scale

0.865

High

598372

SIN3
Transcriptional regulatory protein SIN3

2

4

High-throughput

0.802

High

577522

CYC8
General transcriptional corepressor CYC8

21

16

Small-scale

0.767

High

381849

H4
Histone H4

1

11

Small-scale

0.724

High

598427

H3
Histone H3

1

15

Small-scale

0.724

High

598395

DOA1
Protein DOA1

1

18

High-throughput

0.665

High

598429

SKO1
CRE-binding bZIP protein SKO1

3

0

Small-scale

0.634

High

543716

SSB1
Ribosome-associated molecular chaperone SSB1

3

17

High-throughput

0.633

High

525841

HSP72
Heat shock protein SSA2

3

18

High-throughput

0.624

High

598419

RFX1
RFX-like DNA-binding protein RFX1

2

2

Small-scale

0.617

High

598383

RPD3
Histone deacetylase RPD3

2

20

Small-scale

0.612

High

547845

NHP6B
Non-histone chromosomal protein 6B

2

20

Small-scale

0.609

High

598450

CTI6
Histone deacetylase complex subunit CTI6

2

6

Small-scale

0.602

High

598410

MED3
Mediator of RNA polymerase II transcription subunit 3

2

0

Small-scale

0.598

High

598402

MET30
F-box protein MET30

1

19

High-throughput

0.590

High

598403

SSN3
Meiotic mRNA stability protein kinase SSN3

2

16

Small-scale

0.586

High

598380

MED16
Mediator of RNA polymerase II transcription subunit 16

1

0

Small-scale

0.586

High

598418

MED21
Mediator of RNA polymerase II transcription subunit 21

2

0

Small-scale

0.581

High

408457

GAL80
Galactose/lactose metabolism regulatory protein GAL80

2

0

Small-scale

0.577

High

522961

HSP71
Heat shock protein SSA1

2

16

High-throughput

0.571

High

598401

UME6
Transcriptional regulatory protein UME6

2

0

Small-scale

0.569

High

598425

HDA1
Histone deacetylase HDA1

1

20

Small-scale

0.561

High

598394

DYHC
Dynein heavy chain, cytoplasmic

1

6

High-throughput

0.555

High

598414

SET4
SET domain-containing protein 4

1

7

Small-scale

0.553

High

598460

DBP10
ATP-dependent RNA helicase DBP10

1

15

High-throughput

0.553

High

598408

SSB2
Ribosome-associated molecular chaperone SSB2

2

17

High-throughput

0.552

High

598415

NSE4
Non-structural maintenance of chromosome element 4

2

0

High-throughput

0.541

High

598377

CDC48
Cell division control protein 48

1

7

High-throughput

0.515

High

598455

HOS1
Histone deacetylase HOS1

1

18

Small-scale

0.515

High

148856

CET1
mRNA-capping enzyme subunit beta

1

2

Small-scale

0.512

High

515407

HMAL2
Silenced mating-type protein ALPHA2

1

0

Small-scale

0.504

High

509381

UBI4P
Polyubiquitin [Cleaved into: Ubiquitin]

1

13

Small-scale

0.501

High

598375

ROX1
Repressor ROX1

1

20

Small-scale

0.501

High

598378

DAL80
Nitrogen regulatory protein DAL80

1

12

Small-scale

0.501

High

598391

YOX1
Homeobox protein YOX1

1

6

Small-scale

0.501

High

598411

FKH1
Fork head protein homolog 1

1

10

Small-scale

0.501

High

590518

HSP26
Heat shock protein 26

1

3

High-throughput

0.500

High

598447

DHSO2
Sorbitol dehydrogenase 2

1

1

High-throughput

0.494

High

555287

EI2BD
Translation initiation factor eIF2B subunit delta

1

3

High-throughput

0.489

High

587281

ABP1
Actin-binding protein

1

6

High-throughput

0.489

High

598407

HSP7E
Heat shock protein SSC3, mitochondrial

1

19

High-throughput

0.489

High

598434

CLU
Clustered mitochondria protein 1

1

2

High-throughput

0.489

High

598439

SPH1
Protein SPH1

1

1

High-throughput

0.489

High

598387

KPR1
Ribose-phosphate pyrophosphokinase 1

1

1

Small-scale

0.481

High

438248

NOT3
General negative regulator of transcription subunit 3

1

1

High-throughput

0.481

High

598371

KIN3
Serine/threonine-protein kinase KIN3

1

6

High-throughput

0.481

High

598390

NUF2
Kinetochore protein NUF2

1

8

High-throughput

0.481

High

598421

PFD6
Prefoldin subunit 6

1

7

High-throughput

0.481

High

598423

AF9
Protein AF-9 homolog

1

11

High-throughput

0.481

High

598428

CTR9
RNA polymerase-associated protein CTR9

1

14

High-throughput

0.481

High

598441

MED10
Mediator of RNA polymerase II transcription subunit 10

1

2

Small-scale

0.481

High

598374

URE2
Transcriptional regulator URE2

1

0

Small-scale

0.480

High

598426

MOT3
Transcriptional activator/repressor MOT3

1

0

Small-scale

0.480

High

598449

RDR1
Protein RDR1

1

0

Small-scale

0.480

High

598463

WHI5
G1-specific transcriptional repressor WHI5

1

0

Small-scale

0.480

High

452708

ADR1
Regulatory protein ADR1

1

5

High-throughput

0.479

High

594165

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

3

High-throughput

0.479

High

598370

MED14
Mediator of RNA polymerase II transcription subunit 14

1

2

Small-scale

0.479

High

598379

TF2B
Transcription initiation factor IIB

1

4

High-throughput

0.479

High

598381

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

1

High-throughput

0.479

High

598382

HOG1
Mitogen-activated protein kinase HOG1

1

6

High-throughput

0.479

High

598388

SMY2
Protein SMY2

1

1

High-throughput

0.479

High

598392

DEF1
RNA polymerase II degradation factor 1

1

7

High-throughput

0.479

High

598400

SKN7
Transcription factor SKN7

1

6

Small-scale

0.479

High

598412

DSN1
Kinetochore-associated protein DSN1

1

1

High-throughput

0.479

High

598413

YAP4
AP-1-like transcription factor YAP4

1

2

Small-scale

0.479

High

598417

SSN8
RNA polymerase II holoenzyme cyclin-like subunit

1

5

Small-scale

0.479

High

598432

NRG1
Transcriptional regulator NRG1

1

18

Small-scale

0.479

High

598433

TOM1
E3 ubiquitin-protein ligase TOM1

1

4

High-throughput

0.479

High

598435

YAP6
AP-1-like transcription factor YAP6

1

2

Small-scale

0.479

High

598436

SIZ1
E3 SUMO-protein ligase SIZ1

1

2

High-throughput

0.479

High

598440

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

1

High-throughput

0.479

High

598452

YL11B
Transposon Ty1-LR1 Gag-Pol polyprotein

1

2

High-throughput

0.479

High

598454

SCC1
Sister chromatid cohesion protein 1

1

2

High-throughput

0.479

High

598457

SMT3
Ubiquitin-like protein SMT3

1

1

High-throughput

0.479

High

598461

HMS1
Probable transcription factor HMS1

1

8

High-throughput

0.479

High

598430

CENPP
Inner kinetochore subunit CTF19

1

0

High-throughput

0.460

High

598444

CDC73
Cell division control protein 73

1

0

Small-scale

0.460

High

598384

MED18
Mediator of RNA polymerase II transcription subunit 18

1

0

Small-scale

0.458

High

598396

PHD1
Putative transcription factor PHD1

1

0

Small-scale

0.458

High

598431

ESP1
Separin

1

0

High-throughput

0.458

High

598443

HDA3
HDA1 complex subunit 3

1

0

Small-scale

0.458

High

598448

YAP7
AP-1-like transcription factor YAP7

1

0

Small-scale

0.458

High

598453

MED2
Mediator of RNA polymerase II transcription subunit 2

1

0

Small-scale

0.458

High

367680

ENO1
Enolase 1

1

3

High-throughput

0.457

High

405015

LEU3
3-isopropylmalate dehydrogenase

1

5

High-throughput

0.457

High

598451

THI21
Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase THI21

1

1

High-throughput

0.457

High

392175

HSP82
ATP-dependent molecular chaperone HSP82

1

13

High-throughput

0.445

High

598385

HSP7F
Heat shock protein homolog SSE1

1

20

High-throughput

0.445

High

477507

MYO1
Myosin-1

1

7

High-throughput

0.439

High

598373

SPA2
Protein SPA2

1

12

High-throughput

0.439

High

598376

STP22
Suppressor protein STP22 of temperature-sensitive alpha-factor receptor and arginine permease

1

1

High-throughput

0.439

High

598393

YKT6
Synaptobrevin homolog YKT6

1

1

High-throughput

0.439

High

598399

KOG1
Target of rapamycin complex 1 subunit KOG1

1

19

High-throughput

0.439

High

598404

LAA1
AP-1 accessory protein LAA1

1

2

High-throughput

0.439

High

598406

SNF7
Vacuolar-sorting protein SNF7

1

6

High-throughput

0.439

High

598409

TBP6
Probable 26S proteasome subunit YTA6

1

10

High-throughput

0.439

High

598420

KEL2
Kelch repeat-containing protein 2

1

7

High-throughput

0.439

High

598456

IQG1
Ras GTPase-activating-like protein IQG1

1

7

High-throughput

0.439

High

598458

GYP5
GTPase-activating protein GYP5

1

2

High-throughput

0.439

High

598462

ERP3
Protein ERP3

1

2

High-throughput

0.439

High

598464

HUG1
MEC1-mediated checkpoint protein HUG1

1

0

High-throughput

0.438

High

598397

ATG8
Autophagy-related protein 8

1

2

High-throughput

0.437

High

598398

PP2C7
Protein phosphatase 2C homolog 7, mitochondrial

1

2

High-throughput

0.437

High

394197

EF1A
Elongation factor 1-alpha

1

2

High-throughput

0.407

High

510156

HSP77
Import motor subunit, mitochondrial

1

19

High-throughput

0.407

High

598389

HSP78
Heat shock protein 78, mitochondrial

1

2

High-throughput

0.407

High

598416

SSY5
SPS-sensor serine protease component SSY5

1

0

High-throughput

0.279

Low

154347

YO304
Uncharacterized protein YOR304C-A

1

0

High-throughput

0.251

Low

598386

YEF3
Uncharacterized protein YEL043W

1

0

High-throughput

0.251

Low

598405

MBO1
Gamma tubulin complex adapter SPC72

1

0

High-throughput

0.251

Low

598422

NNF2
Protein NNF2

1

0

High-throughput

0.251

Low

598438

HOB2
Protein YPR117W

1

0

High-throughput

0.251

Low

598442

MMR1
Mitochondrial MYO2 receptor-related protein 1

1

0

High-throughput

0.251

Low

598445

YET3
Endoplasmic reticulum transmembrane protein 3

1

0

High-throughput

0.251

Low

598459

NCA2
Nuclear control of ATPase protein 2

1

0

High-throughput

0.251

Low

438838

CATT
Catalase T

1

0

High-throughput

0.249

Low

598424

SAM50
Sorting assembly machinery 50 kDa subunit

1

0

High-throughput

0.249

Low

598437

COQ9
Ubiquinone biosynthesis protein COQ9, mitochondrial

1

0

High-throughput

0.249

Low

598446

HBT1
Protein HBT1

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025