Protein: RAD59
DNA repair protein RAD59

Gene: RAD59
Organism: Saccharomyces cerevisiae S288C
Interactions: 85
UniProt ID: Q12223

Gene Ontology (top 5):
GO:0000722 - telomere maintenance via recombination
GO:0000724 - double-strand break repair via homologous recombination
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005759 - mitochondrial matrix

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

448479

RAD52
DNA repair and recombination protein RAD52

11

6

Small-scale

0.976

High

1084638

RAD59
DNA repair protein RAD59

2

6

Small-scale

0.800

High

752033

PGM1
Phosphoglucomutase 1

1

1

High-throughput

0.536

High

779117

EF1G2
Elongation factor 1-gamma 2

1

1

High-throughput

0.536

High

788434

PGM2
Phosphoglucomutase 2

1

1

High-throughput

0.536

High

816472

HSP7E
Heat shock protein SSC3, mitochondrial

1

3

High-throughput

0.536

High

818703

GPP2
Glycerol-1-phosphate phosphohydrolase 2

1

1

High-throughput

0.536

High

834733

GPP1
Glycerol-1-phosphate phosphohydrolase 1

1

1

High-throughput

0.536

High

557787

SRS2
ATP-dependent DNA helicase SRS2

1

1

Small-scale

0.527

High

1055391

RSC2
Chromatin structure-remodeling complex subunit RSC2

1

1

Small-scale

0.527

High

533530

AK
Aspartokinase

1

0

High-throughput

0.513

High

594639

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

0

High-throughput

0.513

High

649529

UBA1
Ubiquitin-activating enzyme E1 1

1

0

High-throughput

0.513

High

726018

NTH1
Endonuclease III homolog 1

1

0

High-throughput

0.513

High

750908

PRS6B
26S proteasome regulatory subunit 6B homolog

1

0

High-throughput

0.513

High

757850

PP2C3
Protein phosphatase 2C homolog 3

1

0

High-throughput

0.513

High

797205

OPY1
Pleckstrin homology domain protein OPY1

1

0

High-throughput

0.513

High

815854

BEM2
GTPase-activating protein BEM2/IPL2

1

0

High-throughput

0.513

High

918724

PIL1
Sphingolipid long chain base-responsive protein PIL1

1

0

High-throughput

0.513

High

1043367

OYE2
NADPH dehydrogenase 2

1

0

High-throughput

0.513

High

1043454

YE11B
Transposon Ty1-ER1 Gag-Pol polyprotein

1

0

High-throughput

0.513

High

1084640

AHA1
Hsp90 co-chaperone AHA1

1

0

High-throughput

0.513

High

897524

UBC9
SUMO-conjugating enzyme UBC9

1

3

Small-scale

0.501

High

408366

GAL1
Galactokinase

1

1

High-throughput

0.500

High

416490

HXKA
Hexokinase-1

1

1

High-throughput

0.500

High

453846

PYR1
Multifunctional protein URA2

1

1

High-throughput

0.500

High

470613

RPB2
DNA-directed RNA polymerase II subunit RPB2

1

1

High-throughput

0.500

High

486354

TBA1
Tubulin alpha-1 chain

1

2

High-throughput

0.500

High

592580

VATB
V-type proton ATPase subunit B

1

2

High-throughput

0.500

High

597307

BIP
Endoplasmic reticulum chaperone BiP

1

3

High-throughput

0.500

High

626925

HSP60
Heat shock protein 60, mitochondrial

1

1

High-throughput

0.500

High

671740

SCJ1
DnaJ-related protein SCJ1

1

1

High-throughput

0.500

High

676466

MAS5
Mitochondrial protein import protein MAS5

1

1

High-throughput

0.500

High

680161

CDC48
Cell division control protein 48

1

1

High-throughput

0.500

High

710044

BMH1
Protein BMH1

1

1

High-throughput

0.500

High

763510

MDJ1
DnaJ homolog 1, mitochondrial

1

1

High-throughput

0.500

High

948694

ACT
Actin

1

1

High-throughput

0.500

High

1084641

RUVB2
RuvB-like protein 2

1

2

High-throughput

0.500

High

1042401

GCN5
Histone acetyltransferase GCN5

1

0

High-throughput

0.493

High

613515

ADT3
ADP,ATP carrier protein 3

1

1

High-throughput

0.489

High

737791

IF2G
Eukaryotic translation initiation factor 2 subunit gamma

1

1

High-throughput

0.489

High

918533

RSC1
Chromatin structure-remodeling complex subunit RSC1

1

2

Small-scale

0.481

High

367416

CISY1
Citrate synthase, mitochondrial

1

0

High-throughput

0.479

High

386915

TBB
Tubulin beta chain

1

0

High-throughput

0.479

High

531426

METK1
S-adenosylmethionine synthase 1

1

0

High-throughput

0.479

High

590753

HSP26
Heat shock protein 26

1

0

High-throughput

0.479

High

599093

PFKA2
ATP-dependent 6-phosphofructokinase subunit beta

1

0

High-throughput

0.479

High

740235

RPN2
26S proteasome regulatory subunit RPN2

1

0

High-throughput

0.479

High

746319

UGPA1
UTP--glucose-1-phosphate uridylyltransferase

1

0

High-throughput

0.479

High

817986

IMB4
Importin subunit beta-4

1

0

High-throughput

0.479

High

865106

TCPQ
T-complex protein 1 subunit theta

1

0

High-throughput

0.479

High

1033905

PRS8
26S proteasome regulatory subunit 8 homolog

1

0

High-throughput

0.479

High

647857

RFA1
Replication factor A protein 1

1

4

Small-scale

0.479

High

675353

RAD51
DNA repair protein RAD51

1

6

Small-scale

0.479

High

688775

RFA2
Replication factor A protein 2

1

3

Small-scale

0.479

High

963790

H3
Histone H3

1

1

High-throughput

0.479

High

1084642

CMR1
DNA damage-binding protein CMR1

1

1

High-throughput

0.479

High

708529

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.458

High

367148

ATPB
ATP synthase subunit beta, mitochondrial

1

2

High-throughput

0.457

High

425158

OTC
Ornithine carbamoyltransferase

1

2

High-throughput

0.457

High

607800

HXKG
Glucokinase-1

1

1

High-throughput

0.457

High

613650

ADT2
ADP,ATP carrier protein 2

1

1

High-throughput

0.457

High

926293

ALDH6
Magnesium-activated aldehyde dehydrogenase, cytosolic

1

1

High-throughput

0.457

High

510906

HSP77
Import motor subunit, mitochondrial

1

2

High-throughput

0.445

High

525548

HSP71
Heat shock protein SSA1

1

4

High-throughput

0.445

High

528014

HSP72
Heat shock protein SSA2

1

4

High-throughput

0.445

High

546741

SSB1
Ribosome-associated molecular chaperone SSB1

1

5

High-throughput

0.445

High

1084639

SMT3
Ubiquitin-like protein SMT3

1

3

Small-scale

0.408

High

740122

SCM4
Protein SCM4

2

0

Small-scale

0.295

High

849604

SNZ3
Probable pyridoxal 5'-phosphate synthase subunit SNZ3

2

0

Small-scale

0.295

High

455534

PMM
Phosphomannomutase

1

0

High-throughput

0.279

Low

456468

ILVB
Acetolactate synthase catalytic subunit, mitochondrial

1

0

High-throughput

0.279

Low

480010

PRTB
Cerevisin

1

0

High-throughput

0.279

Low

743730

VATD
V-type proton ATPase subunit D

1

0

High-throughput

0.279

Low

793119

ATPG
ATP synthase subunit gamma, mitochondrial

1

0

High-throughput

0.279

Low

800403

YPT31
GTP-binding protein YPT31/YPT8

1

0

High-throughput

0.279

Low

836119

COPB2
Coatomer subunit beta'

1

0

High-throughput

0.279

Low

368773

PMG1
Phosphoglycerate mutase 1

1

0

High-throughput

0.261

Low

405155

LEU3
3-isopropylmalate dehydrogenase

1

0

High-throughput

0.261

Low

408597

GAL10
Bifunctional protein GAL10 [Includes: UDP-glucose 4-epimerase

1

0

High-throughput

0.261

Low

585577

BGL2
Glucan 1,3-beta-glucosidase

1

0

High-throughput

0.261

Low

619392

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

0

High-throughput

0.261

Low

528882

RLA3
Large ribosomal subunit protein P1B

1

0

High-throughput

0.238

Low

1084643

VPS5
Vacuolar protein sorting-associated protein 5

1

0

High-throughput

0.238

Low


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Last updated: 11Aug2025