HitPredict

Interactor 1: MTOR (P42345)
Serine/threonine-protein kinase mTOR (EC 2.7.11.1) (FK506-binding protein 12-rapamycin complex-associated protein 1) (FKBP12-rapamycin complex-associated protein) (Mammalian target of rapamycin) (mTOR) (Mechanistic target of rapamycin) (Rapamycin and FKBP12 target 1) (Rapamycin target protein 1)
Gene: MTOR

Interactor 2: PD1L1 (Q9NZQ7)
Programmed cell death 1 ligand 1 (PD-L1) (PDCD1 ligand 1) (Programmed death ligand 1) (hPD-L1) (B7 homolog 1) (B7-H1) (CD antigen CD274)
Gene: CD274

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.80	0.60	0.694

Property	Details
Experiments	26186194, 28514442, 32941674, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0031295 - T cell costimulation
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 2549 Hs			1 290
+	Hs
		787545 MTOR_HUMAN (1-2549): 0: 2102: 100.00		VSIG2_HUMAN (3-270): 3.76e-40: 144: 15.11
+	Hs
		706885 MTOR_HUMAN (1-2549): 0: 2102: 100.00		CD80_HUMAN (28-259): 6.01e-30: 116: 21.07
+	Hs
		787412 MTOR_HUMAN (1-2549): 0: 2102: 100.00		MUC18_HUMAN (20-245): 2.36e-12: 69.1: 17.17
+	Hs
		1031630 ATM_HUMAN (387-2548): 0: 894: 14.98		PD1L1_HUMAN (1-290): 1.08e-62: 201: 100.00
+	Hs
		1038186 ATR_HUMAN (186-2548): 0: 816: 14.82		PD1L1_HUMAN (1-290): 1.08e-62: 201: 100.00
+	Hs
		706892 ATM_HUMAN (387-2548): 0: 894: 14.98		CD80_HUMAN (28-259): 6.01e-30: 116: 21.07
+	Hs
		1038153 ATR_HUMAN (186-2548): 0: 816: 14.82		VSIG2_HUMAN (3-270): 3.76e-40: 144: 15.11
+	Hs
		706895 ATR_HUMAN (186-2548): 0: 816: 14.82		CD80_HUMAN (28-259): 6.01e-30: 116: 21.07
+	Hs
		1166469 TRRAP_HUMAN (925-2548): 0: 720: 15.53		BTNL3_HUMAN (1-266): 5.33e-54: 183: 18.08
+	Hs
		944464 PRKDC_HUMAN (695-2548): 0: 686: 14.83		PD1L1_HUMAN (1-290): 1.08e-62: 201: 100.00
+	Hs
		706889 PRKDC_HUMAN (695-2548): 0: 686: 14.83		CD80_HUMAN (28-259): 6.01e-30: 116: 21.07
+	Hs
		1117805 Q4LE69_HUMAN (733-2453): 1.63e-160: 553: 12.12		PD1L1_HUMAN (1-290): 1.08e-62: 201: 100.00
+	Hs
		1268274 GCN1_HUMAN (245-1372): 1.05e-38: 162: 12.17		PD1L1_HUMAN (1-290): 1.08e-62: 201: 100.00