HitPredict

Interactor 1: EPS15 (P42566)
Epidermal growth factor receptor substrate 15 (Protein Eps15) (Protein AF-1p)
Gene: EPS15

Interactor 2: CRKL (P46109)
Crk-like protein
Gene: CRKL

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	33961781, 19380743
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0045296 - cadherin binding
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 896 Hs			1 303
+	Hs
		787861 EPS15_HUMAN (1-896): 5.15e-160: 493: 100.00		CRK_HUMAN (3-302): 8.95e-54: 179: 55.21
+	Hs
		61732 EPS15_HUMAN (1-896): 5.15e-160: 493: 100.00		A6H8W8_HUMAN (74-298): 2.13e-17: 84.9: 16.44
+	Hs
		787985 EPS15_HUMAN (1-896): 5.15e-160: 493: 100.00		ITSN2_HUMAN (74-298): 1.63e-17: 84.9: 16.44
+	Hs
		557629 EPS15_HUMAN (1-896): 5.15e-160: 493: 100.00		NCK1_HUMAN (85-196): 4.12e-16: 79.8: 22.81
+	Hs
		787889 EPS15_HUMAN (1-896): 5.15e-160: 493: 100.00		GRB2_HUMAN (240-295): 1.72e-10: 61.8: 26.32
+	Hs
		1349275 ITSN2_HUMAN (3-845): 2.31e-61: 229: 14.40		ITSN2_HUMAN (74-298): 1.63e-17: 84.9: 16.44
+	Hs
		1285205 ITSN2_HUMAN (3-845): 2.31e-61: 229: 14.40		SH3K1_HUMAN (219-297): 1.64e-15: 78.7: 24.69
+	Hs
		1078919 ITSN1_HUMAN (2-520): 3.13e-38: 157: 14.61		ITSN2_HUMAN (74-298): 1.63e-17: 84.9: 16.44
+	Hs
		1078886 ITSN1_HUMAN (2-520): 3.13e-38: 157: 14.61		SH3K1_HUMAN (219-297): 1.64e-15: 78.7: 24.69
+	Hs
		1349279 EP15R_HUMAN (417-891): 5.86e-14: 78.3: 11.98		ITSN2_HUMAN (74-298): 1.63e-17: 84.9: 16.44
+	Hs
		61738 EP15R_HUMAN (417-891): 5.86e-14: 78.3: 11.98		A6H8W8_HUMAN (74-298): 2.13e-17: 84.9: 16.44
+	Hs
		924919 EP15R_HUMAN (417-891): 5.86e-14: 78.3: 11.98		GRB2_HUMAN (240-295): 1.72e-10: 61.8: 26.32