HitPredict

Interactor 1: EPS15 (P42566)
Epidermal growth factor receptor substrate 15 (Protein Eps15) (Protein AF-1p)
Gene: EPS15

Interactor 2: ITSN2 (Q9NZM3)
Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein)
Gene: ITSN2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.57	0.60	0.586

Property	Details
Experiments	32203420, 22558309
Identification Methods	affinity chromatography technology, two hybrid
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005509 - calcium ion binding GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0016197 - endosomal transport
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 896 Hs			1 1697
+	Hs
		61732 EPS15_HUMAN (1-896): 5.15e-160: 493: 100.00		A6H8W8_HUMAN (2-1697): 0: 946: 98.35
+	Hs
		787920 EPS15_HUMAN (1-896): 5.15e-160: 493: 100.00		ITSN1_HUMAN (2-1693): 0: 863: 56.23
+	Cl
		47357 A0A8I3PJA6_CANLF (1-896): 5.87e-149: 464: 92.91		F1PHV6_CANLF (2-1693): 0: 875: 56.51
+	Mm
		788010 EPS15_MOUSE (1-896): 6.54e-132: 419: 88.54		ITSN1_MOUSE (2-1693): 0: 861: 56.37
+	Hs
		1349275 ITSN2_HUMAN (3-845): 2.31e-61: 229: 14.40		ITSN2_HUMAN (1-1697): 0: 969: 100.00
+	Hs
		1078919 ITSN2_HUMAN (3-845): 2.31e-61: 229: 14.40		ITSN1_HUMAN (2-1693): 0: 863: 56.23
+	Hs
		1078828 ITSN1_HUMAN (2-520): 3.13e-38: 157: 14.61		ITSN1_HUMAN (2-1693): 0: 863: 56.23
+	Hs
		787987 EPS15_HUMAN (1-896): 5.15e-160: 493: 100.00		EP15R_HUMAN (3-509): 1.83e-36: 152: 16.67
+	Hs
		787860 EPS15_HUMAN (1-896): 5.15e-160: 493: 100.00		EPS15_HUMAN (7-478): 5.01e-32: 138: 16.98
+	Mm
		787998 EPS15_MOUSE (1-896): 6.54e-132: 419: 88.54		EPS15_MOUSE (7-405): 5.97e-31: 134: 17.56
+	Mm
		788002 EPS15_MOUSE (1-896): 6.54e-132: 419: 88.54		EP15R_MOUSE (13-132): 1.69e-16: 87.7: 27.87
+	Hs
		279897 ITSN2_HUMAN (3-845): 2.31e-61: 229: 14.40		TRIO_HUMAN (205-1561): 3.77e-74: 277: 10.84
+	Hs
		61738 A6H8W8_HUMAN (6-845): 1.24e-62: 233: 14.86		EP15R_HUMAN (3-509): 1.83e-36: 152: 16.67
+	Hs
		1349279 ITSN2_HUMAN (3-845): 2.31e-61: 229: 14.40		EP15R_HUMAN (3-509): 1.83e-36: 152: 16.67
+	Dm
		91151 M9ND00_DROME (3-680): 3.38e-47: 184: 16.43		E3CTP7_DROME (216-327): 1.05e-15: 85.2: 34.82
+	Mm
		1141846 ITSN1_MOUSE (2-737): 1.82e-38: 158: 11.80		EP15R_MOUSE (13-132): 1.69e-16: 87.7: 27.87
+	Rn
		957077 MRCKB_RAT (227-886): 5.86e-43: 172: 11.89		KALRN_RAT (216-869): 6.93e-09: 63.3: 8.32