HitPredict

Interactor 1: MUC18 (P43121)
Cell surface glycoprotein MUC18 (Cell surface glycoprotein P1H12) (Melanoma cell adhesion molecule) (Melanoma-associated antigen A32) (Melanoma-associated antigen MUC18) (S-endo 1 endothelial-associated antigen) (CD antigen CD146)
Gene: MCAM

Interactor 2: RAC1 (P63000)
Ras-related C3 botulinum toxin substrate 1 (EC 3.6.5.2) (Cell migration-inducing gene 5 protein) (Ras-like protein TC25) (p21-Rac1)
Gene: RAC1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Ras~V-set
Common GO terms	GO:0005886 - plasma membrane GO:0005925 - focal adhesion GO:0007155 - cell adhesion GO:0009653 - anatomical structure morphogenesis
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 646 Hs			1 192
+	Hs
		564444 MUC18_HUMAN (1-646): 3.41e-136: 414: 100.00		RHOQ_HUMAN (4-187): 4.46e-85: 251: 64.67
+	Hs
		545250 MUC18_HUMAN (1-646): 3.41e-136: 414: 100.00		RAC2_HUMAN (1-192): 1.2e-82: 244: 92.19
+	Hs
		793471 MUC18_HUMAN (1-646): 3.41e-136: 414: 100.00		RHOJ_HUMAN (2-189): 1.38e-80: 240: 60.64
+	Hs
		793246 MUC18_HUMAN (1-646): 3.41e-136: 414: 100.00		RAC3_HUMAN (1-191): 2.72e-79: 236: 93.19
+	Hs
		793271 MUC18_HUMAN (1-646): 3.41e-136: 414: 100.00		RHOG_HUMAN (1-192): 3.1e-79: 236: 71.35
+	Hs
		793248 MUC18_HUMAN (1-646): 3.41e-136: 414: 100.00		CDC42_HUMAN (1-192): 1.4e-78: 234: 70.31
+	Hs
		793252 MUC18_HUMAN (1-646): 3.41e-136: 414: 100.00		RHOA_HUMAN (5-192): 3.5e-77: 230: 57.98
+	Hs
		436192 MUC18_HUMAN (1-646): 3.41e-136: 414: 100.00		RHOC_HUMAN (5-192): 8.68e-75: 224: 57.45
+	Hs
		892359 CD166_HUMAN (13-607): 2.71e-98: 314: 22.33		RAC3_HUMAN (1-191): 2.72e-79: 236: 93.19
+	Hs
		1031170 PTK7_HUMAN (17-627): 1.64e-70: 249: 12.68		RHOJ_HUMAN (2-189): 1.38e-80: 240: 60.64
+	Hs
		894276 PXDN_HUMAN (183-555): 5.6e-61: 222: 20.77		CDC42_HUMAN (1-192): 1.4e-78: 234: 70.31
+	Hs
		925521 KIRR1_HUMAN (240-644): 1.88e-28: 123: 15.77		RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00
+	Hs
		564645 KIRR1_HUMAN (240-644): 1.88e-28: 123: 15.77		RHOQ_HUMAN (4-187): 4.46e-85: 251: 64.67
+	Hs
		545561 KIRR1_HUMAN (240-644): 1.88e-28: 123: 15.77		RAC2_HUMAN (1-192): 1.2e-82: 244: 92.19
+	Hs
		1294920 KIRR1_HUMAN (240-644): 1.88e-28: 123: 15.77		RHOJ_HUMAN (2-189): 1.38e-80: 240: 60.64
+	Hs
		892541 KIRR1_HUMAN (240-644): 1.88e-28: 123: 15.77		RAC3_HUMAN (1-191): 2.72e-79: 236: 93.19
+	Hs
		951238 KIRR1_HUMAN (240-644): 1.88e-28: 123: 15.77		RHOG_HUMAN (1-192): 3.1e-79: 236: 71.35
+	Hs
		894314 KIRR1_HUMAN (240-644): 1.88e-28: 123: 15.77		CDC42_HUMAN (1-192): 1.4e-78: 234: 70.31
+	Hs
		900803 KIRR1_HUMAN (240-644): 1.88e-28: 123: 15.77		RHOA_HUMAN (5-192): 3.5e-77: 230: 57.98
+	Hs
		436458 KIRR1_HUMAN (240-644): 1.88e-28: 123: 15.77		RHOC_HUMAN (5-192): 8.68e-75: 224: 57.45