Protein: TMED4
Transmembrane emp24 domain-containing protein 4 (Endoplasmic reticulum stress-response protein 25) (ERS25) (GMP25iso) (Putative NF-kappa-B-activating protein 156) (p24 family protein alpha-3) (p24alpha3)

Gene: TMED4
Organism: Homo sapiens
Interactions: 81
UniProt ID: Q7Z7H5

Gene Ontology (top 5):
GO:0005783 - endoplasmic reticulum
GO:0005789 - endoplasmic reticulum membrane
GO:0005793 - endoplasmic reticulum-Golgi intermediate compartment
GO:0005794 - Golgi apparatus
GO:0006886 - intracellular protein transport

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

888911

TMEDA
Transmembrane emp24 domain-containing protein 10

6

17

High-throughput

0.945

High

1146568

TMED2
Transmembrane emp24 domain-containing protein 2

5

17

High-throughput

0.925

High

1281283

TMED3
Transmembrane emp24 domain-containing protein 3

3

17

High-throughput

0.861

High

1281281

TMED5
Transmembrane emp24 domain-containing protein 5

2

17

High-throughput

0.776

High

1281268

TMED9
Transmembrane emp24 domain-containing protein 9

1

18

High-throughput

0.691

High

1281282

TMED7
Transmembrane emp24 domain-containing protein 7

1

18

High-throughput

0.691

High

1281272

GORS2
Golgi reassembly-stacking protein 2

3

16

High-throughput

0.675

High

1281271

CHST8
Carbohydrate sulfotransferase 8

4

4

High-throughput

0.630

High

1281265

CK5P3
CDK5 regulatory subunit-associated protein 3

2

3

High-throughput

0.628

High

1281284

LIPG
Endothelial lipase

2

3

High-throughput

0.628

High

1281276

SCN3B
Sodium channel regulatory subunit beta-3

3

1

High-throughput

0.604

High

546984

FGF3
Fibroblast growth factor 3

2

5

High-throughput

0.574

High

1128910

I13R2
Interleukin-13 receptor subunit alpha-2

2

2

High-throughput

0.574

High

1281255

SPP2B
Signal peptide peptidase-like 2B

2

5

High-throughput

0.574

High

1281256

5HT3C
5-hydroxytryptamine receptor 3C

2

1

High-throughput

0.558

High

1281254

S7A14
Solute carrier family 7 member 14

2

9

High-throughput

0.549

High

219326

B4GA1
Beta-1,4-glucuronyltransferase 1

1

2

High-throughput

0.536

High

789157

NUP62
Nuclear pore glycoprotein p62

1

2

High-throughput

0.536

High

936078

PAR2
Proteinase-activated receptor 2

1

5

High-throughput

0.536

High

981306

RAB1A
Ras-related protein Rab-1A

1

7

High-throughput

0.536

High

1063384

GOGA2
Golgin subfamily A member 2

1

5

High-throughput

0.536

High

1281259

AT2A3
Sarcoplasmic/endoplasmic reticulum calcium ATPase 3

1

4

High-throughput

0.536

High

1281260

YIPF5
Protein YIPF5

1

5

High-throughput

0.536

High

1281266

SEC62
Translocation protein SEC62

1

1

High-throughput

0.536

High

1281279

FBX2
F-box only protein 2

1

2

High-throughput

0.536

High

351787

LGI1
Leucine-rich glioma-inactivated protein 1

1

0

High-throughput

0.513

High

1281285

SPCS1
Signal peptidase complex subunit 1

1

0

High-throughput

0.513

High

471112

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

1

High-throughput

0.489

High

1120541

NID2
Nidogen-2

1

1

High-throughput

0.489

High

1281262

RUSD4
Pseudouridylate synthase RPUSD4, mitochondrial

1

2

High-throughput

0.489

High

1281267

MBB1A
Myb-binding protein 1A

1

3

High-throughput

0.489

High

1281269

TMM59
Transmembrane protein 59

1

1

High-throughput

0.489

High

1281273

CRLF2
Cytokine receptor-like factor 2

1

1

High-throughput

0.489

High

218392

TGON2
Trans-Golgi network integral membrane protein 2

1

5

High-throughput

0.479

High

242148

PRKN
E3 ubiquitin-protein ligase parkin

1

2

High-throughput

0.479

High

401065

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

1

High-throughput

0.479

High

1083118

GALT2
Polypeptide N-acetylgalactosaminyltransferase 2

1

2

High-throughput

0.479

High

1136251

EMC2
ER membrane protein complex subunit 2

1

3

High-throughput

0.479

High

1219286

ECM29
Proteasome adapter and scaffold protein ECM29

1

1

Small-scale

0.479

High

1281250

EMC5
ER membrane protein complex subunit 5

1

2

High-throughput

0.479

High

1281251

EMC1
ER membrane protein complex subunit 1

1

3

High-throughput

0.479

High

1281261

LRC59
Leucine-rich repeat-containing protein 59

1

2

High-throughput

0.479

High

1281252

ZNT5
Proton-coupled zinc antiporter SLC30A5

1

10

High-throughput

0.445

High

1281264

DDRGK
DDRGK domain-containing protein 1

1

3

High-throughput

0.445

High

1281270

MAGT1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit MAGT1

1

5

High-throughput

0.445

High

1281280

S35A3
UDP-N-acetylglucosamine transporter

1

2

High-throughput

0.445

High

589041

RFA2
Replication protein A 32 kDa subunit

1

4

High-throughput

0.437

High

695829

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

4

High-throughput

0.437

High

768540

RFA3
Replication protein A 14 kDa subunit

1

3

High-throughput

0.437

High

947216

NLRP6
NACHT, LRR and PYD domains-containing protein 6

1

6

High-throughput

0.437

High

1024663

VIGLN
Vigilin

1

1

High-throughput

0.437

High

1140488

KIF14
Kinesin-like protein KIF14

1

5

High-throughput

0.437

High

1252104

SYNE3
Nesprin-3

1

2

High-throughput

0.437

High

1254433

TRI67
Tripartite motif-containing protein 67

1

6

High-throughput

0.437

High

1281253

LNX1
E3 ubiquitin-protein ligase LNX

1

3

Small-scale

0.437

High

1281258

ESR2
Estrogen receptor beta

1

11

High-throughput

0.437

High

1281274

T106B
Transmembrane protein 106B

1

4

High-throughput

0.437

High

1281278

ZRAN1
Ubiquitin thioesterase ZRANB1

1

3

High-throughput

0.437

High

256069

S19A2
Thiamine transporter 1

1

3

High-throughput

0.407

High

530026

TAU
Microtubule-associated protein tau

1

4

High-throughput

0.407

High

722509

CTR1
High affinity cationic amino acid transporter 1

1

11

High-throughput

0.407

High

1131562

MFS10
Major facilitator superfamily domain-containing protein 10

1

2

High-throughput

0.407

High

1153406

CD226
CD226 antigen

1

3

High-throughput

0.407

High

1236204

MFSD5
Molybdate-anion transporter

1

5

High-throughput

0.407

High

1242153

NPAL3
NIPA-like protein 3

1

4

High-throughput

0.407

High

1246081

GTR7
Solute carrier family 2, facilitated glucose transporter member 7

1

4

High-throughput

0.407

High

1281257

CTR3
Cationic amino acid transporter 3

1

9

High-throughput

0.407

High

1281263

SAAL1
Protein SAAL1

1

2

High-throughput

0.407

High

1281275

CLDN1
Claudin domain-containing protein 1

1

1

High-throughput

0.407

High

1281277

S53A1
Solute carrier family 53 member 1

1

2

High-throughput

0.407

High

717317

PEBP1
Phosphatidylethanolamine-binding protein 1

2

0

High-throughput

0.298

High

1092454

TIAM1
Rho guanine nucleotide exchange factor TIAM1

1

0

High-throughput

0.282

High

125026

KCNK1
Potassium channel subfamily K member 1

1

0

High-throughput

0.279

Low

608299

EGLN
Endoglin

1

0

High-throughput

0.279

Low

851157

ACHA4
Neuronal acetylcholine receptor subunit alpha-4

1

0

High-throughput

0.279

Low

871786

RFX3
Transcription factor RFX3

1

0

High-throughput

0.279

Low

1256389

TPGS1
Tubulin polyglutamylase complex subunit 1

1

0

High-throughput

0.279

Low

1278601

HEAT3
HEAT repeat-containing protein 3

1

0

High-throughput

0.279

Low

1281249

PNM8A
Paraneoplastic antigen-like protein 8A

1

0

High-throughput

0.279

Low

502410

H2A1
Histone H2A type 1

1

0

High-throughput

0.249

Low

942719

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025