HitPredict

Interactor 1: BRCA1 (P38398)
Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1)
Gene: BRCA1

Interactor 2: MDC1 (Q14676)
Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1)
Gene: MDC1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.77	1.00	0.881

Property	Details
Experiments	29656893, 17525332, 21622030, 12611903
Identification Methods	proximity labelling technology, affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	BRCT~BRCT_2
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005694 - chromosome GO:0006281 - DNA repair GO:0006974 - DNA damage response and 1 others more... GO:0016604 - nuclear body
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 1863 Hs			1 2089
+	Hs
		798785 BRCA1_HUMAN (1-1863): 0: 1570: 100.00		BRCA1_HUMAN (405-2081): 8.49e-75: 279: 8.23
+	Hs
		798813 BRCA1_HUMAN (1-1863): 0: 1570: 100.00		KI67_HUMAN (38-1926): 1.25e-69: 263: 9.54
+	Hs
		799014 BRCA1_HUMAN (1-1863): 0: 1570: 100.00		AKA12_HUMAN (183-1892): 1.7e-43: 177: 11.75
+	Hs
		799211 BRCA1_HUMAN (1-1863): 0: 1570: 100.00		NIPBL_HUMAN (869-1889): 7.8e-21: 103: 15.38
+	Hs
		799337 BRCA1_HUMAN (1-1863): 0: 1570: 100.00		TITIN_HUMAN (137-816): 5.64e-12: 74.2: 7.90
+	Hs
		1129668 TOPB1_HUMAN (1122-1861): 4.09e-150: 505: 14.12		MDC1_HUMAN (1-2089): 0: 680: 100.00
+	Hs
		1129715 BARD1_HUMAN (13-366): 8.77e-32: 137: 11.98		MDC1_HUMAN (1-2089): 0: 680: 100.00
+	Hs
		799342 TOPB1_HUMAN (1122-1861): 4.09e-150: 505: 14.12		BRCA1_HUMAN (405-2081): 8.49e-75: 279: 8.23
+	Hs
		854196 TOPB1_HUMAN (1122-1861): 4.09e-150: 505: 14.12		KI67_HUMAN (38-1926): 1.25e-69: 263: 9.54
+	Hs
		799308 MCPH1_HUMAN (1150-1857): 1.33e-95: 331: 14.19		BRCA1_HUMAN (405-2081): 8.49e-75: 279: 8.23
+	Hs
		1364217 TOPB1_HUMAN (1122-1861): 4.09e-150: 505: 14.12		MINT_HUMAN (224-1896): 3.16e-16: 88.1: 11.94
+	Hs
		571891 TRI27_HUMAN (13-390): 6.01e-69: 244: 11.74		BRCA1_HUMAN (405-2081): 8.49e-75: 279: 8.23
+	Hs
		799434 BARD1_HUMAN (13-366): 8.77e-32: 137: 11.98		BRCA1_HUMAN (405-2081): 8.49e-75: 279: 8.23
+	Hs
		854254 BARD1_HUMAN (13-366): 8.77e-32: 137: 11.98		KI67_HUMAN (38-1926): 1.25e-69: 263: 9.54
+	Xl
		1362146 Q90X95_XENLA (9-373): 1.5e-26: 120: 12.50		Q90X96_XENLA (1093-2080): 1.91e-67: 255: 10.15
+	Hs
		572271 TRI27_HUMAN (13-390): 6.01e-69: 244: 11.74		MAGL2_HUMAN (1335-1939): 3.03e-19: 97.3: 11.41
+	Hs
		623437 RO52_HUMAN (15-390): 5.97e-69: 243: 12.86		AGRG4_HUMAN (792-1903): 8.41e-19: 96.3: 14.06
+	Hs
		1089288 TRI26_HUMAN (12-287): 2.54e-51: 193: 14.53		SRRM2_HUMAN (97-1940): 1.48e-24: 115: 8.27
+	Hs
		1406807 BARD1_HUMAN (13-366): 8.77e-32: 137: 11.98		SRRM2_HUMAN (97-1940): 1.48e-24: 115: 8.27