HitPredict

Interactor 1: BRCA1 (P38398)
Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1)
Gene: BRCA1

Interactor 2: RIF1 (Q5UIP0)
Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog)
Gene: RIF1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	29656893
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0006281 - DNA repair and 1 others more... GO:0006974 - DNA damage response
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 1863 Hs			1 2472
+	Hs
		1217170 TOPB1_HUMAN (1122-1861): 4.09e-150: 505: 14.12		RIF1_HUMAN (1-2472): 0: 1719: 100.00
+	Hs
		623383 RO52_HUMAN (15-390): 5.97e-69: 243: 12.86		RIF1_HUMAN (1-2472): 0: 1719: 100.00
+	Hs
		799211 BRCA1_HUMAN (1-1863): 0: 1570: 100.00		NIPBL_HUMAN (948-1837): 3.17e-19: 98.1: 12.40
+	Hs
		799116 BRCA1_HUMAN (1-1863): 0: 1570: 100.00		MDC1_HUMAN (958-2272): 4.97e-18: 93.9: 10.74
+	Hs
		799337 BRCA1_HUMAN (1-1863): 0: 1570: 100.00		TITIN_HUMAN (1353-2455): 8.62e-10: 66.9: 8.12
+	Hs
		1279876 TOPB1_HUMAN (1122-1861): 4.09e-150: 505: 14.12		RBBP6_HUMAN (1213-2173): 5.47e-27: 123: 9.31
+	Hs
		1129668 TOPB1_HUMAN (1122-1861): 4.09e-150: 505: 14.12		MDC1_HUMAN (958-2272): 4.97e-18: 93.9: 10.74
+	Hs
		1364217 TOPB1_HUMAN (1122-1861): 4.09e-150: 505: 14.12		MINT_HUMAN (982-2369): 1.35e-11: 72.9: 7.17
+	Hs
		623437 RO52_HUMAN (15-390): 5.97e-69: 243: 12.86		AGRG4_HUMAN (735-2455): 6.59e-37: 156: 9.49
+	Hs
		1089224 TRI26_HUMAN (12-287): 2.54e-51: 193: 14.53		CNTRL_HUMAN (924-2161): 1.92e-36: 154: 10.94
+	Hs
		1129715 BARD1_HUMAN (13-366): 8.77e-32: 137: 11.98		MDC1_HUMAN (958-2272): 4.97e-18: 93.9: 10.74