HitPredict

Interactor 1: BRCA1 (P38398)
Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1)
Gene: BRCA1

Interactor 2: GCC1 (Q96CN9)
GRIP and coiled-coil domain-containing protein 1 (Golgi coiled-coil protein 1)
Gene: GCC1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.50	0.439

Property	Details
Experiments	25184681
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 1863 Hs			1 775
+	Hs
		773114 BRCA1_HUMAN (1-1863): 0: 1570: 100.00		MYH10_HUMAN (207-775): 4.49e-25: 114: 11.78
+	Hs
		772651 BRCA1_HUMAN (1-1863): 0: 1570: 100.00		MYH9_HUMAN (2-459): 7.22e-18: 90.9: 11.35
+	Hs
		799241 BRCA1_HUMAN (1-1863): 0: 1570: 100.00		MYH14_HUMAN (31-580): 9.53e-18: 90.5: 10.59
+	Hs
		157033 BRCA1_HUMAN (1-1863): 0: 1570: 100.00		CTRO_HUMAN (156-700): 4.66e-13: 75.3: 17.66
+	Hs
		587580 BRCA1_HUMAN (1-1863): 0: 1570: 100.00		DESP_HUMAN (131-704): 1.25e-11: 70.7: 17.71
+	Hs
		799134 BRCA1_HUMAN (1-1863): 0: 1570: 100.00		PLEC_HUMAN (150-708): 1.83e-10: 67.2: 17.67
+	Hs
		157686 TOPB1_HUMAN (1122-1861): 4.09e-150: 505: 14.12		CTRO_HUMAN (156-700): 4.66e-13: 75.3: 17.66
+	Hs
		587753 TOPB1_HUMAN (1122-1861): 4.09e-150: 505: 14.12		DESP_HUMAN (131-704): 1.25e-11: 70.7: 17.71
+	Hs
		773270 TRIM6_HUMAN (10-377): 7.06e-68: 240: 13.54		MYH10_HUMAN (207-775): 4.49e-25: 114: 11.78
+	Hs
		556952 TRIM6_HUMAN (10-377): 7.06e-68: 240: 13.54		MYH7_HUMAN (4-575): 4.95e-21: 101: 10.79
+	Hs
		773006 TRIM6_HUMAN (10-377): 7.06e-68: 240: 13.54		MYH9_HUMAN (2-459): 7.22e-18: 90.9: 11.35
+	Hs
		563033 TRIM6_HUMAN (10-377): 7.06e-68: 240: 13.54		MYH6_HUMAN (400-775): 1.42e-12: 73.9: 9.04
+	Hs
		587554 RO52_HUMAN (15-390): 5.97e-69: 243: 12.86		DESP_HUMAN (131-704): 1.25e-11: 70.7: 17.71
+	Hs
		623354 RO52_HUMAN (15-390): 5.97e-69: 243: 12.86		PLEC_HUMAN (150-708): 1.83e-10: 67.2: 17.67
+	Hs
		157821 TRIM4_HUMAN (15-377): 9.13e-63: 225: 11.52		CTRO_HUMAN (156-700): 4.66e-13: 75.3: 17.66
+	Hs
		773269 TRI31_HUMAN (15-120): 1.69e-29: 125: 28.30		MYH10_HUMAN (207-775): 4.49e-25: 114: 11.78
+	Hs
		773005 TRI31_HUMAN (15-120): 1.69e-29: 125: 28.30		MYH9_HUMAN (2-459): 7.22e-18: 90.9: 11.35
+	Hs
		1277780 TRI31_HUMAN (15-120): 1.69e-29: 125: 28.30		MYH14_HUMAN (31-580): 9.53e-18: 90.5: 10.59
+	Mm
		1169543 TRI72_MOUSE (18-91): 9.45e-12: 71.5: 30.26		MYH9_MOUSE (2-459): 6.9e-19: 94.3: 11.79